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Background: The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders characterized by accumulation of autofluorescent material in many tissues, especially in neurons. Mutations in the CLN8 gene, encoding an endoplasmic reticulum ( ER) transmembrane protein of unknown function, underlie NCL phenotypes in humans and mice. The human phenotype is characterized by

Background: Mutations in the PRSS1 gene explain most occurrences of hereditary pancreatitis (HP) but many HP families have no PRSS1 mutation. Recently, an association between the mutation N34S in the pancreatic secretary trypsin inhibitor (SPINK1 or PSTI) gene and idiopathic chronic pancreatitis (ICP) was reported. It is unclear whether the N34S mutation is a cause of pancreatitis per se, whether

D. Briihl and A. W. Inhoff (1995) found that exterior letter pairs showed no privileged status in reading when letter pairs were presented as parafoveal primes. However, T. R. Jordan, S. M. Thomas, G. R. Patching, and K. C. Scott-Brown (2003) used a paradigm that (a) allowed letter pairs to exert influence at any point in the reading process, (b) overcame problems with the stimulus manipulations u

There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced by the endocrine cells. In the present study, we show that islets intended for islet transplantation produce tissue factor in both the transmembrane and

BACKGROUND: Knowledge about the social and economical determinants of prescription is relevant in health care systems like the Swedish one, which is based on the principle of equity, and which aims to allocate resources on the basis of need and not on criteria that are based on social constructs. We therefore investigated the association between patient and health care practice (HCP) characteristi

Background: The therapeutic alliance may be a moderating factor of outcome in the Attempted Suicide Short Intervention Program (ASSIP). Aims: This study investigates the two components of the therapeutic alliance, patients' satisfaction with the therapeutic relationship and therapeutic outcome and their associations with suicidal ideation over time. Method: A total of 120 patients (55% female; mea

AIMS/HYPOTHESIS: Several studies have suggested that large fat cells are less responsive to insulin than small fat cells. However, in these studies, large fat cells from obese individuals were compared with smaller fat cells from leaner participants, in effect making it impossible to draw conclusions about whether there is a causal relationship between fat cell size and insulin sensitivity. We hyp

AIMS: This study aimed to investigate the association between the 'Shrunken pore syndrome' (SPS) and risk of death, 30 day rehospitalization, and health-related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C /eGFRcreatinine ratio.METHODS AND RESULTS: A total of 373 p

Background: Semi-natural pastures are unfertilized grasslands with a long history of traditional low-input grazing management. This kind of pastures are recognized for their high species richness. However, as a consequence of modernization of agriculture, many of the semi-natural pastures have been lost during the last century, leading to a serious threat to farmland biodiversity. Semi-natural pas

Background: The decision to admit into the hospital from the emergency department (ED) is considered to be important and challenging. The aim was to assess whether previously published results suggesting an association between hospital bed occupancy and likelihood of hospital admission from the ED can be reproduced in a different study population. Methods: A retrospective cohort study of attendanc

This thesis analyzes how digitalization in elderly care affects cost-efficiency and quality of care. More specifically, digitalization in elderly care is divided into welfare technologies and E-services. The study goes into how well digitalization meets its promises of solving many of our society's future problems regarding elderly care, such as an aging population. In order to analyze this, I

The purpose of this study is to quantitatively discover whether green brand knowledge has an effect on the perception of green claims with Swedish Millennial's and Gen Z. As to whether it is perceived as credible or greenwashing. This study builds upon previous brand knowledge and green claim literature. However, where previous research has green brand knowledge as the dependent variable and t

In this master thesis it is investigated where the housing shortage that Sweden faces in 2003 comes from. Starting from two alternative scenarios, a scapegoat is looked for: either the industry is responsible for lowering the supply of housing by increasing the cost of dwellings through illegal cartel agreements, or the state is to be blamed for distorting market forces through an inadequate housi

The doctrine of joint criminal enterprise (JCE) is a form of individual criminal liability in international criminal law. This doctrine was formed by the Appeals Chamber of the ICTY in the Tadić Case in 1999. Since then, the JCE has grown to play a major role in the charges and convictions before international criminal tribunal. Due to this doctrine, the members who formed the criminal plan are re

Bladder cancer tumors expressing human epidermal growth factor receptor 4 (HER4) demonstrate improved patient survival. HER4 isoforms and estrogen receptor alpha (ER-α) can form chaperone complexes causing cell-proliferation. We wanted to explore if HER4 isoforms and ER-α could correlate to poor prognosis in bladder cancers. We developed mRNA assays for HER4 isoforms (JM-a, JM-b, CYT1, and CYT2) a