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Background: The transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) plays a role in carcinogenesis and is involved in processes, such as proliferation, differentiation, drug resistance and immunosuppression. STAT3 can be activated by phosphorylation of tyrosine at position 705 (pSTAT3Tyr705) or serine at 727 (pSTAT3Ser727). High expression levels of pSTAT3 are implicate
The incidence of papillary thyroid cancer (PTC) has been steadily rising, though the underlying mechanism remains unclear. This study aims to elucidate the biological role of TM4SF4 in the PTC progression. Our differential expression analysis indicated that TM4SF4 was significantly upregulated in PTC, which was corroborated in both our local cohort and the data from Human Protein Atlas. Additional
Background: Multimorbidity, i.e. two or more non-communicable diseases (NCDs), has been associated with venous thromboembolism (VTE), but whether multimorbidity is a predictor for incident VTE is unknown. Aims: To examine the associations between multimorbidity and its severity with risk of incident VTE, and examine the association between nine different disease clusters and incident VTE. Methods:
Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early
Background: This systematic review and meta-analysis assesses the association between metabolic syndrome and breast cancer (BC) outcomes in BC survivors. Methods: Systematic searches were carried out in PubMed and Embase using variations of the search terms: breast neoplasms (population), metabolic syndrome (exposure), and survival (outcome). Metabolic syndrome was characterized according to the A
Purpose: This systematic literature review aims to develop a comprehensive understanding of effort as a multidimensional construct in individuals with impaired swallowing and/or spoken communication. Method: A comprehensive literature search was conducted across three data-bases: PubMed/MEDLINE, Embase, and CINAHL, covering publications from 1966 to 2024. The search included terms related to commu
Objective: To investigate whether low daily doses of fluoridated milk, as an adjunct to oral hygiene routines with fluoridated toothpaste, can prevent caries development in enamel and dentine in adolescents. Material and methods: Adolescents (mean age 13 years) at three dental clinics in Sweden were enrolled to a randomised clinical trial (RCT) including baseline and 2-year follow-up examinations.
Säkerheten om demokratins robusthet har gett vika för en allmänt diagnostiserad demokratikris. Allt fler röster höjs för att försvara de demokratiska institutionerna mot dem som vill avskaffa dem på formellt demokratisk väg. Men för att värna demokratin, hävdas det, krävs paradoxalt nog att man håller tillbaka den demokratiska omvandlingen. I denna avhandling hävdas att denna ”demokratiska paradoCertainty about the robustness of democracy has given way to a widely diagnosed crisis of democracy. There are increasing calls to defend democratic institutions against those who seek their formally democratic abolishment. But safeguarding democracy, it is argued, paradoxically requires restraining democratic transformation. This dissertation argues that this ‘democratic paradox’ is misconceived.
Melanin-based color polymorphism is predicted to evolve and maintain through differential fitness of morphs in different environments, and several empirical studies indicate that life history strategies, physiology, and behavior vary among color morphs. Sex allocation theory predicts that parents should adjust their sex allocation based on differential costs of raising sons and daughters, and ther
Differential growth is central to eukaryotic morphogenesis. We showed using cellular imaging, simulations, and perturbations that light-induced differential growth in a curved organ, the Arabidopsis thaliana apical hook, emerges from the longitudinal expansion of subepidermal cells, acting in parallel with a differential in the material properties of epidermal cell walls that resist expansion. The
The chemical industry stands as a critical player in the global effort to combat climate change and achieve environmental sustainability. As the world is getting closer to crucial temperature thresholds, the need for decarbonisation becomes increasingly urgent. Thus, this paper focuses on BASF as the biggest chemical company in Germany but also globally and the German chemical industry in general,
This paper analyzes Donald Trump’s evolving rhetoric on undocumented migration during the Biden administration, building on previous literature related to the use of language to delegitimize migrants. Employing a discourse analysis based on Laclau and Mouffe’s discourse theory, we examine Donald Trump's remarks surrounding illegal immigrants in the United States through 7 major speeches from 2
Aviation in Europe has undergone an enormous change from national rulemaking to common European rulemaking. Behind this change is the European Union’s decision to delegate some policy implementation functions to decentralised agencies. The European Union Aviation Safety Agency (EASA) is one of these EU agencies and has specific authorisation to implement decisions that directly impact individuals,
