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The glycoprotein osteopontin plays important roles in several states of disease associated with inflammation, for example by recruiting neutrophils but its expression and possible roles in cystic fibrosis (CF) have not been investigated.

Germ layer formation and primary axis development rely on Fibroblast growth factors (FGFs). In Xenopus, the secreted serine protease HtrA1 induces mesoderm and posterior trunk/tail structures by facilitating the spread of FGF signals. Here, we show that the serpin Protease nexin-1 (PN1) is transcriptionally activated by FGF signals, suppresses mesoderm and promotes head development in mRNA-injecte

Variants in the TCF7L2 gene (transcription factor 7-like 2) have shown strong association with type 2 diabetes with two defined risk haplotypes, HapA and HapB(T2D). TCF7L2 may play a role in both glucose homeostasis and adipogenesis. Our aim was to characterize the TCF7L2 mRNA expression and regulation in human adipose tissue. We quantified TCF7L2 mRNA levels in cultured human adipocytes and in bi

Background and aims: Asthma is one of the most common respiratory diseases in the world. Research has shown that temporal increases in air pollution concentrations can aggravate asthma symptoms. The aim of this study was to assess whether individuals living in areas with higher air pollution concentrations responded differently to short-term temporal exposure to air pollution than those living in

Aim It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA1c, blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes. Methods Questionnaire data, including measure of SOC, was colle

This study explores author texts on public libraries in the United Kingdom between the years 2010 and 2018. The texts appear in a national public debate about the value, purpose and direction of the library service following a significant number of library closures and funding cuts. These were the result of the global financial crisis of 2007 and 2008 and the subsequent implementation of the auste

Degrowth scholars have been criticised for focusing too much on theory and macro-level of analysis, giving less attention to actual degrowth practices that happen at the local level. This thesis aims to make a contribution to this second field of degrowth research. Drawing on a practice theory approach, the objective of the study was to find whether degrowth practices and ideas have the potential

Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study was to investigate levels of serotonin in patients with the autoimmune disease systemic lupus eryth

Females of the Indian meal moth, Plodia interpunctella, and females of the Mediterranean flour month, Ephestia kuehniella (both Lepidoptera: Pyralidae), exhibit daily rhythms in calling behavior. The peak in P. interpunctella calling occurs at dusk, whereas E. kuehniella calls preferentially at dawn. This behavior turned arrhythmic in P. interpunctella females in constant darkness (DD) and remaine

Injury to the brain (e.g., stroke) results in a disruption of neuronal connectivity and loss of fundamental sensori-motor functions. The subsequent recovery of certain functions involves structural rearrangements in areas adjacent to the infarct. This remodeling of the injured brain requires trafficking of macromolecular components including cholesterol and phospholipids, a transport carried out b

Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves candidates for causality, but simply act as markers for functional variants. By means of imputation

This research study is based on the problematisation of criminal gangs’ development within Swedish society and its presence towards young Swedish individuals. Furthermore, the study was built on investigating changes that take place within legislations. This study’s research problem and purpose was designed to investigate whether mitigating circumstances within the Swedish Penal Code can result in

Sexuell exploatering och övergrepp av soldater inom FN:s fredsoperationer är ett välkänt problem för FN. Organisationens brist på ansvarsutkrävande kom till utryck när OHCHR begärde att Anders Kompass skulle avgå från sin tjänst för att ha överfört en rapport till en medlemsstat i hopp om att en utredning skulle påbörjas. Syftet med denna uppsats är att belysa problematiken inom OHCHR:s organisati

The thesis places itself in the scope of two intensively ongoing debates. The first concerns the concepts of ‘sustainability’ and ‘sustainable development’, and the second concerns Swedish forestry policy. Assigned by the government, the Swedish Forestry Agency published the report ‘Forestry with new possibilities’ in late 2019, aiming to produce clear steps for future sustainable forestry in Swed

Despite being increasingly identified as main drivers of the global environmental emergency and existing inequalities, growth-driven economies have managed to perpetuate. Discursive practices are central to this perpetuation, strengthening the growth paradigm and its evolution towards ‘greener’ approaches, such as ‘green growth’. This work uses content analysis on presidential speeches to assess h

Thesis purpose: The aims of this thesis are to investigate (1) the effect of sponsorship disclosure timing (before vs. after) on attitudes towards the brand and attitudes towards the vlogger in a beauty vlog context and (2) test a possible moderating effect of discount codes on the relationships between disclosure timing and attitudes towards the brand and the vlogger. These two aims were pursued