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Autoimmune regulator (AIRE) is a transcriptional regulator expressed in the thymus and necessary for maintaining immunological self-tolerance. Extra-thymic AIRE expression is rare and a role for AIRE in tumor-associated innate immune cells has not yet been established. In this study we show that AIRE is expressed in human pro-tumor neutrophils. In breast cancer, AIRE was primarily located to tumor
Colour polymorphism can be maintained by colour morph-specific benefits across environmental conditions. Currently, the amount and the duration of snow cover during winter decrease especially in northern latitudes, which can alter the potential for camouflage of animals with light and dark morphs. Tawny owls, Strix aluco, are colour-polymorphic avian predators with dark (brown) and light (grey) co
Cigarette smoking is a risk factor for osteoporosis and bone fracture. Moreover, smoking causes exposure to cadmium, which is a known risk factor for osteoporosis. It is hypothesized that part of smoking-induced osteoporosis may be mediated via cadmium from tobacco smoke. We investigated this hypothesis using mediation analysis in a Swedish cohort of elderly men. This study was performed in 886 el
Eight Brides for Twenty-Four Brothers Four Brides for Twelve Brothers: How to Dutch Book a Group of Individually Rational Players 1 Luc Bovens London School of Economics and Political Science Dept. of Philosophy, Logic and Scientific Method L.Bovens@LSE.ac.uk You can’t be wise and in love at the same time. (Bob Dylan) Abstract. Wlodek Rabinowicz suggested in an e-mail conversation (2001) to me tha
https://www.fil.lu.se/hommageawlodek/site/papper/BovensLuc.pdf - 2026-07-12
Recent work has shown that coagulation and innate immunity are tightly interwoven host responses that help eradicate an invading pathogen. Some bacterial species including Staphylococcus aureus secrete pro-coagulant factors that in turn can modulate these immune reactions. Such mechanisms may not only protect the microorganism from a lethal attack, but also promote bacterial proliferation and the
To identify stop-codon variants associated with blood pressure (BP).
Ligand stimulation of the platelet-derived growth factor (PDGF) beta-receptor leads to activation of its intrinsic tyrosine kinase and autophosphorylation of the intracellular part of the receptor. The autophosphorylated tyrosine residues mediate interactions with downstream signal transduction molecules and thereby initiate different signalling pathways. A pathway leading to activation of the GTP
This study explored individual differences in eye movements during visual imagery. Eye movements were recorded for participants who recalled a picture from memory while looking at a blank screen. All participants were tested for working memory capacity and the OSIVQ (Blazhenkova & Kozhevnikov, 2009) was used as an assessment for individual differences in object imagery, spatial imagery and ver
Selective estrogen receptor beta (ER beta) agonists display neuroprotective properties in animal models and hold promise in the treatment of neurodegenerative diseases. In our quest to design, synthesize and evaluate potent and safe ER beta agonists, we focused on making an analogue of 16 beta,17 alpha-estriol (16,17-epiestriol), a potent and one of the most ER beta selective endogenous estrogens
Urokinase-type plasminogen activator (uPA) is an extracellular protease that plays a pivotal role in tumor progression. uPA activity is spatially restricted by its anchorage to high-affinity uPA receptors (uPAR) at the cell surface. High tumor tissue expression of uPA and uPAR is associated with poor prognosis in lung, breast, and colon cancer patients in clinical studies. Genetic deficiency of uP
In the dual pursuit of expanding non-fossil fuel electricity capacity and becoming a ‘developed’ nation, India’s development trajectory drives the rapid expansion of large-scale solar photovoltaics (PV). In Jaisalmer, however, this expansion encounters complex socio-ecological landscapes marked by questions of (in)justice and uneven development. Drawing on energy geographies and energy justice, th
Gene amplification is considered to be one responsible cause for upregulation of Programmed Death Ligand-1 (PD-L1) in non-small cell lung cancer (NSCLC) and to represent a specific molecular subgroup possibly associated with immunotherapy response. Our aim was to analyze the frequency of PD-L1 amplification, its relation to PD-L1 mRNA and protein expression, and to characterize the immune microenv
In the reality of Israel’s educational system, it is highly unlikely that Arab and Jewish students will ever meet at school. Within this state-segregated context, bilingual multicultural education, while having the potential to act as a catalyst for change and promote intercultural dialogue, remains on the brim of academic interests. The purpose of this thesis is to examine the complex interplay o
This study examines the relationship between various types of external support and the duration of intrastate conflicts. Between 1975 and 2017, the majority of conflicts received external support in one shape or form and the effects of internationalising conflicts through the provision of external support are multiple. Existing literature has found that external involvement generally prolongs the
In this qualitative and poststructuralist policy analysis, the Swedish Crime policy is examined as it is expressed through three political documents from three different parties during the post-election period of October 2022-March 2024. Using Laclau and Mouffe’s discourse theory, with its Lacanian influence on the subject, this paper investigates the political language used in the policy area dur
The Romanian healthcare system faces various structural issues such as corruption, underfunding, and lack of modernization. As hospitals make every effort to cope with the COVID-19 pandemic around the country, there have been two deadly hospital fires. This study strives to reconstruct and evaluate Romanian President Klaus Iohannis’ arguments given in favor of health reform in response to the two
Students performs differently in international comparable school evaluations such as TIMSS and PISA. One possible explanation discussed in economic research literature is that differences in the amount of instruction time across countries are the reason for international gaps in student performance. Using a within-student between-subject fixed effects model and the data from the TIMSS 2019 evaluat
