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BACKGROUND: Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI). AIM: To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality. MATERIALS AND METHODS:
Serine proteases play a central role in defense against pathogens by regulating processes such as blood clotting, melanization of injured surfaces, and proteolytic activation of signaling pathways involved in innate immunity. Here, we present the functional characterization of the Drosophila serine protease Sp7 (CG3006) by inducible RNA interference. We show that Sp7 is constitutively expressed in
Magnesium chelatase inserts Mg2+ into protoporphyrin IX and is the first unique enzyme of the chlorophyll biosynthetic pathway. It is a heterotrimeric enzyme, composed of I- (40 kDa), D- (70 kDa) and H- (140 kDa) subunits. The I- and D-proteins belong to the family of AAA(+) (ATPases associated with various cellular activities), but only I-subunit hydrolyses ATP to ADP. The D-subunits provide a pl
Background: The classic Bernard-Soulier syndrome (BSS) is a rare inherited thrombocytopenia (IT) associated with severe thrombocytopenia, giant platelets, and bleeding tendency caused by homozygous or compound heterozygous variants in GP1BA, GP1BB, or GP9. Monoallelic BSS (mBSS) associated with mild asymptomatic macrothrombocytopenia caused by heterozygous variants in GP1BA or GP1BB may be a frequ
The polymerization of amino acids into proteins occurs on ribosomes, with the rate influenced by the amino acids being polymerized. The imino acid proline is a poor donor and acceptor for peptide-bond formation, such that translational stalling occurs when three or more consecutive prolines (PPP) are encountered by the ribosome. In bacteria, stalling at PPP motifs is rescued by the elongation fact
Understanding the role of technology characteristics and the context in the diffusion of new energy technologies is important for assessing feasibility of climate mitigation. We examine the historical adoption of nuclear power as a case of a complex large scale energy technology. We conduct an event history analysis of grid connections of first sizable commercial nuclear power reactors in 79 count
An important manifestation of severe COVID-19 is the ARDS-like lung injury that is associated with vascular endothelialitis, thrombosis, and angiogenesis. The intravascular innate immune system (IIIS), including the complement, contact, coagulation, and fibrinolysis systems, which is crucial for recognizing and eliminating microorganisms and debris in the body, is likely to be involved in the path
Monetary policy has been suggested to show a fading impact on domestic inflation. Based on this, the study tests whether this has occurred with Swedish monetary policy over the period January 2000 – January 2020. This is done by studying the impact of monetary policy on consumer price inflation and real estate prices in Sweden, comparing the results to the United States. The used method consists o
Purpose: A pilot study to identify bacterial biofilm in the lacrimal sacs of patients with chronic dacryocystitis, and in patients with epiphora but without discharge, using scanning electron microscopy. Methods: Five patients: two with nasolacrimal duct obstruction without dacryocystitis, and three with dacryocystitis refractory to antibiotics, underwent external dacryocystorhinostomy. One contro
The ways in which expectations for the future shape how actors and organizations make sense of the present has received growing interest and attention among science and technology scholars – with particular attention being paid to the role of expectations and prediction making in technology and finance. Nevertheless, while the imaginaries involved in the futures described by tech-entrepreneurs and
Keynote speech of a conference organized by the Swedish Network for European Legal Studies (SNELS)
The future role of AI in healthcare is largely seen as positive, inevitable, necessary, and driven by the private sector. These dominant narratives obscure decision-making about these future applications, with little room for political scrutiny, or public participation. Public, and private resources, are being funnelled to support various AI health technologies. By prioritising some and not others
Abstract in Uncoded languagesIn this article we discuss four basic approaches to characterising droughts namely meteorological, hydrological, agricultural, and socioeconomic. In the first three approaches, drought is defined and measured as a physical phenomenon primarily related to the precipitation shortfall. Socioeconomic drought, nonetheless, is described and determined as the 'supply' and 'de
Denna uppsats undersöker de levda erfarenheterna hos japanska migranter i Sverige, en grupp som omfattar cirka 4 600 individer, varav nästan 80 procent har valt att permanent bosätta sig i Sverige. De återstående 20 procenten är tillfälliga invånare, som studenter, forskare eller utstationerade chefer, verksamma i något av de cirka 200 japanskägda företagen i landet. Till skillnad från andra europThis thesis explores the lived experiences of Japanese migrants to Sweden, a demographic that includes approximately 4,600 individuals, of whom nearly 80 percent chose to settle permanently in Sweden. The remaining 20 percent are temporary residents, as students, researchers, or as expatriate managers, working in one of the roughly 200 Japanese-owned companies in the country. In contrast to other
This thesis explores the impact of medical migration on the healthcare crisis in East Africa. With a qualitative research design of ten semi-structured interviews it shall help to understand the relationship between medical migration and the healthcare crisis in East Africa. Accordingly, by interviewing doctors with ties to East Africa and relevant experiences for the topic of study, the following
The number of international students in higher education is steadily increasing, so their experiences in the new environment is a topic gaining more and more interest from academics (Wu & Hammond, 2011). The current research suggests a model for determining international students’ happiness. The determining factors in the hypothesized model are university satisfaction, residential satisfaction
‘Rewilding’, or the return of degraded lands to a state of ‘wilderness’, is a bold attempt to resolve the world’s ecological challenges. It however does not address the division between nature and society, which lies at the core of the issues. According to Marshall Sahlins (1972) and Nurit Bird-David (1992), indigenous people relate to ‘nature’ in a markedly different way than Westerners. Capturin
Gold mining causes various negative social and environmental impacts in countries of extraction like Colombia. Voluntary and legal efforts to tackle these challenges have recently increased in Europe. To understand the complex supply chain and the impact of the newly evolved governance structures better, more research is needed. Based on a literature review and interviews, I identify important Eur
