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Objective To investigate whether polymorphisms in Toll-like receptor (TLR) genes, previously reported to be associated with immune-mediated diseases, are involved in systemic sclerosis (SSc). Methods. We genotyped 14 polymorphisms in the genes for TLRs 2, 4, 7, 8, and 9 in a discovery cohort comprising 452 SSc patients and 537 controls and a replication cohort consisting of 1,170 SSc patients and
Objective. To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression. Methods. We measured the mechanical axis from long limb radiographs from the Multicenter Osteoarthritis Study (MOST) and the Osteoarthritis Initiative (OAI) to define limbs with valgus malalignment (mechanical axis of >= 1.1 degrees valgus) and examined the effect of valgus alignment versus
The molecular mechanism of substrate analogue interaction with Escherichia coli dUTPase was investigated, using the non-hydrolyzable 2'-deoxyuridine 5'-(α,β-imido)triphosphate (α,β-imido-dUTP). Binding of this analogue induces a difference in the far UV circular dichroism (CD) spectrum arguing for a significant change in protein conformation. The spectral shift is strictly Mg2+-dependent, does not
Structural maintenance of chromosome (SMC) complexes organize and regulate genomes via DNA loop extrusion. During this process, the complexes increase the loop size by reeling in DNA from one or both sides of the loop. The factors governing this symmetry remain unclear. Here, we combine single-molecule analysis and molecular dynamic simulations to investigate the symmetry of loop extrusion of vari
Description: Early interventions with PMDs can improve the independence and developmental outcomes of children with disabilities. Increasing awareness and interdisciplinary collaboration are essential to overcome barriers to access to PMDs. Expanding global partnerships and integrating PMDs into clinical and educational settings can increase children's access to mobility. ABSTRACT: Background The Description: Early interventions with PMDs can improve the independence and developmental outcomes of children with disabilities. Increasing awareness and interdisciplinary collaboration are essential to overcome barriers to access to PMDs. Expanding global partnerships and integrating PMDs into clinical and educational settings can increase children's access to mobility. ABSTRACT: Background The
https://www.vetenskaphalsa.se/tag/corona/ - 2026-07-11
Med fokus på parasportares skador – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Med fokus på parasportares skador 2016-09-07 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Idag drar Paralympics igång i Rio. Den svenska truppens ansvari
https://www.vetenskaphalsa.se/med-fokus-pa-parasportares-skador/ - 2026-07-12
A classical solution for matching two image patches is to use the cross-correlation coefficient. This works well if there is a lot of structure within the patches, but not so well if the patches are close to uniform. This means that some patches are matched with more confidence than others. By estimating this uncertainty, more weight can be put on the confident matches than those that are more unc
Kvinnor med svår knäskada mår sämre än män – Vetenskap och Hälsa Hoppa till innehåll Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Kvinnor med svår knäskada mår sämre än män 2010-05-21 ⚠️ Den här artikeln är mer än 5 år gammal. Nya forskningsrön kan ha tillkommit. Kvinnor som drabbas av en allvarlig knäskada
https://www.vetenskaphalsa.se/kvinnor-med-svar-knaskada-mar-samre-an-man/ - 2026-07-12
IntroductionSlow sand filtration is an established method for drinking water treatment, however, the knowledge about their microbial ecology remains limited. Maintenance of slow sand filters (SSF) includes washing to remove biofilm growth in the sand and restore flow through the filter. Understanding how this impacts produced water is important as the SSF may influence the bacterial flora in the f
