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Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin (HTT) gene. Skeletal muscle wasting alongside central pathology is a well-recognized phenomenon seen in patients with HD and HD mouse models. HD muscle atrophy progresses with disease and affects prognosis and quality of life. Satellite cells, progenitors of mature skeletal muscle fibers, are essential for proliferation,

The study can statistically certify that there exists a negative relationship between EV/EBIT-ratio and returns among stocks on the OMX Copenhagen Exchange between 2011-2021. It can also be concluded that EV/EBIT should not be used as the single factor when making investment decisions due to a low r-squared value. Portfolios consisting of low EV/EBIT companies managed to outperform high EV/EBIT po

This paper provides the first regional econometric decomposition of CO2 emissions from fuel combustion in eight regions of the world. Using the best publically-available time series data (1971–2011), the analysis examines the key determinants and relationships of the ‘Green Energy Economy’ (GEE) in Africa, Asia, Latin America and the Caribbean, the Middle East, Non-OECD Europe and countries from t

Creativity is the essence of game design. Managing creativity within organizations can be thought of as being contradictory, and increased empirical research is made within this area, trying to understand the problematic with managing creativity along with more traditional management in business contexts. Even though the research area is substantial on this matter, there is still limited amount of

The possibility to make environmental strategy a part of the core strategy through a framework called inside-out/outside-in was suggested by Porter in 2007. Researchers have also stated that the output of implementing a certain strategy ought to be valued during strategy planning. The two areas; environmental strategy and profitability analysis have although not frequently been combined, and thus

Does it pay to adopt Climate-Smart Practices? Despite the general understanding that CSA practices or innovative land management methods increase farmers’ food security, the key to the current debate within the literature is to understand the extent to which CSA practices explain differences in farmers’ productivity and resilience to climatic shocks. To fill this gap, this study examines the varia

The purpose of this study was to examine ecotourism in the Kelabit Highlands, Malaysia, in terms of the sustainability of the industry. The empirical material, which is based on interviews carried out in the field, is analysed within the context of sustainable development theory in order to examine the central and most critical factors in determining the long-term future of ecotourism in the Kelab

Macroeconomic conditions heavily influence financial markets, and the leading corpus of theory in the field lays out some general principles observed by investors and asset managers alike. However, while the theory is sound, it is hard to measure how much effect these conditions have. To better understand this scenario, this study uses a novel technique that combines traditional causal inference w

Background: The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction. Methods: The PPARGC1A Gly482Ser polymorphism was genotyped in a community-based cohort of 499 men and 533 women, w

This thesis centers on a well-studied cohort of 100 patients, which received a treatment regimen of initial rehabilitation and activity modification to cope with Anterior Cruciate Ligament (ACL) injury. The data, collected prospectively and longitudinally, cover a span of 15 years after initial injury. The overall aim of this thesis is to describe the course of an ACL injury treated with rehabilit

In this paper we argue that the emergence of the dominant model of university organization, which is characterized by a large agglomeration of many (often loosely affiliated) small research groups, might have an economic explanation that relates to the features of the scientific production process. In particular, we argue that there are decreasing returns to scale on the level of the individual re

China is the country in the world with the strongest economic development for the last three decades with an average economic growth of 9 percent annually. The country is very controlled and the government is in power of the media as well as the Internet. But according to the modernization theory China should be a democracy. The theory is presenting a correlation between economic development and d

A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was established in 2009. The presence of three abnormal findings out of five components qualifies a person for the metabolic syndrome: elevated waist circumference, elevated triglycerides, reduced high-density