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Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique feature that distinguishes DS from CS is the presence of iduronic acid (IdoA) in DS. Here, we repor
The weak D phenotype is the most common D variant, with a frequency of 0.2-1% in Caucasian individuals. There are several weak D types, with different frequencies in European countries, which may pose serologic problems and have the potential for alloimmunization. Samples from Portuguese individuals were tested for RhD by two or three distinct monoclonal and oligoclonal antisera, in direct aggluti
The homolytic cleavage of the organometallic Co-C bond in vitamin B-12-dependent enzymes is accelerated by a factor of similar to 10(12) in the protein compared to that of the isolated cofactor in aqueous solution. To understand this much debated effect, we have studied the Co-C bond cleavage in the enzyme glutamate mutase with combined quantum and molecular mechanics methods. We show that the cal
The in vitro effects of the nitric oxide (NO) substrate L-arginine on ciliary beat frequency and the in vivo effects of the NO donor sodium nitroprusside (SNP) on mucociliary activity were investigated in the rabbit maxillary sinus mucosa with photoelectric techniques. L-Arginine increased ciliary beat frequency in vitro with a maximum response of 27.1% +/- 6.4% at 10(-3) mol/L, and this effect wa
This paper provides the first regional econometric decomposition of CO2 emissions from fuel combustion in eight regions of the world. Using the best publically-available time series data (1971–2011), the analysis examines the key determinants and relationships of the ‘Green Energy Economy’ (GEE) in Africa, Asia, Latin America and the Caribbean, the Middle East, Non-OECD Europe and countries from t
Rescuing stalled ribosomes often involves their splitting into subunits. In many bacteria, the resultant large subunits bearing peptidyl-tRNAs are processed by the ribosome-associated quality control (RQC) apparatus that extends the C termini of the incomplete nascent polypeptides with polyalanine tails to facilitate their degradation. Although the tailing mechanism is well established, it is uncl
Drawing from the rich literature in behavioural finance and extensive analysis of forum data from a UK equity crowdfunding platform, we present a comprehensive framework that delineates the investment decision-making process of equity crowdfunders. Our framework captures the utilitarian, emotional, and expressive investment motives that drive crowdfunders, their behaviours and actions during and a
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platele
In the same way that the practice of cardiology has evolved over the years, so too has the way cardiology fellows in training (FITs) are trained. Propelled by recent advances in technology-catalysed by COVID-19-and the requirement to adapt age-old methods of both teaching and healthcare delivery, many aspects, or 'domains', of learning have changed. These include the environments in which FITs wor
This chapter analyses an unexplored field of study: male sex workers. Indeed, while their female counterparts have been widely researched, there is a lack of attention on men who sell sex. For this reason, we aim to (re)shape the representations, theories, rhetoric, organisation, and types of male sex work as a complex, uncomfortable, and controversial phenomenon. First we engage with a social his
This article provides a critical view of Judgment No. 238 of 2014 handed down by the Italian Constitutional Court. By and large the comments presented below pertain to the single issue of the relationship between different legal orders - between the legal orders of two states, or between the legal order of one state and the legal order of international law. The following comments are based on a po
It is unclear how ammonia is transported by proteins from the Amt/Mep/Rh superfamily. We investigated this for the ammonium transporter TaAMT1;1 from wheat expressed in Xenopus oocytes by two-electrode voltage clamp and radio-labeled uptakes. Inward currents were activated by NH +4 or methylammonium ions (MeA+). Importantly, currents increas
Local democracy is theoretically based on political parties offering different policies across and within sub-national geographical units. However, local democracy is embedded within a multilevel party and institutional structure that may compromise this endeavour. This study develops three expectations of policy variation: within party variation in political positions across geographical units; d
This book offers a first look at transnational education corporations, new firms that operate international schools. The quiet rise of transnational education corporations – or TECs – has implications for education systems around the globe, as corporate interests gain a greater stake in the way schools operate. The story of their ascendance links government policies in one corner of the world with
The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor microenvironment, in which regulatory T cells (Treg) play a pivotal role in immunologic tolerance. In this study, we investigated the impact of complement facto
Applying traditional Corporate Finance and Corporate Governance theories, the purpose of this paper is to examine “the crowd’s” capability of being a good investor. Our main finding is that “the crowd” is highly sophisticated and consist of individuals capable of being good investors. We are also able to show that “the crowd” will act significantly more sophisticated in the situation of equity com
