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Popular Abstract in Swedish Oberoende av om det är i ett samhälle, datornätverk eller organen i en mänsklig kropp, så är behovet av kommunikation stort i en komplex miljö. Eftersom den komplicerade människokroppen är beroende av kommunikation för att reglera funktioner, skickas otaliga mängder signaler oavbrutet. För att signalerna skall vara meningsfulla så måste de kunna tas emot och behandlas. Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. Since an estimated 50% of all clinical drugs act on 30 known GPCRs, the rem

This paper quantitatively analyzes the importance of taste versus health in food demand, as well as the effect on consumers’ experienced taste of the non-intrinsic value of healthy labels. Our analysis is based on taste experiments and Vickrey second price auctions on potato chips and bread. Our findings imply a large positive effect on demand for potato chips from higher taste scores: when consum

In 2014 the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy (RAV) conducted a review and analysis of the state of knowledge on the duration of follow-up after exposure to human immunodeficiency virus (HIV). Up until then a follow-up of 12 weeks after exposure had been recommended, but improved tests and new information on early diagnosis motivated a re-evaluati

The ability of rabbit deep flexor tendons to restore the gliding surface and to heal, without the normal contribution of the superficial epitenon layer of the tendons, was studied by light and scanning electron microscopy. The epitenon layer was carefully removed, from defined segments of the tendons. The remaining central tendon tissue was divided, sutured and placed in diffusion chambers subcuta

We have developed over the past years an experimental magnetic resonance imaging (MRI) and polarized gases compatible mechanical respirator for the study of the small experimental animal. The respirator has been successfully used for experiments both in the MRI setting for polarized (3)He, (19)F, and proton imaging as well as for functional measurements of the lungs. The new main pneumatic valve w

DNA polymerases make up a family of enzymes responsible for regulating DNA replication and repair, which in turn maintains the integrity of the genome. However, despite intensive kinetic, crystallographic, and computational studies, elucidation of the detailed enzymatic mechanism still presents a significant challenge. We recently developed an alternative strategy for exploring the fidelity and me

OBJECTIVES: The Apollo study was designed to support the clinical performance verification of the adjusted cutoffs of the Elecsys® β-Amyloid(1-42) (Aβ42) cerebrospinal fluid (CSF) II, β-Amyloid(1-40) (Aβ40) CSF, Phospho-Tau (181P) (pTau) CSF and Total-Tau (tTau) CSF immunoassays (Roche Diagnostics International Ltd) for measuring fresh CSF samples, and assess the concordance of the Elecsys CSF pTa

A generic search is presented for a heavy particle decaying to WZ -> lvl'l' (l, l' = e, mu) final states. The data were recorded by the ATLAS detector in root s = 7 TeV pp collisions at the Large Hadron Collider and correspond to an integrated luminosity of 1.02 fb(-1). The transverse mass distribution of the selected WZ candidates is found to be consistent with the standard model expectation. Upp

Deep learning has advanced flood forecasting through its strong nonlinear modeling capabilities. However, accuracy declines and robustness remain insufficient at longer forecast lead times. Therefore, an evolutionary deep learning model for flood forecasting was developed by integrating time-varying filter-based empirical mode decomposition (TVFEMD), sample entropy-based signal reconstruction (SE)

This article explores how the humanities were imagined by UNESCO to contribute to their quest for improved international relations and worldwide peace. It analyses the negotiations on what role the humanities could play in diplomatic work by looking at the process that led to the founding of the International Council for Philosophy and Humanistic Studies (ICPHS/CIPSH) in 1949. Despite being ingrai

BACKGROUND: The Leiden group and the Assessment of Spondyloarthritis International Society (ASAS)-MRI study group have proposed definitions for structural (SL) and active (AL) lesions typical for axial spondyloarthritis (axSpA) on MRI of the sacroiliac joints (MRI-SIJ).OBJECTIVES: To analyse the predictive validity of proposed SL and AL MRI-SIJ definitions in early axSpA and compare proposed AL wi

Sedan det europeiska projektets tidiga dagar har de underliggande ekonomiska motiven för integrationen konfronterats med allmänna intressen såsom oro för miljön. Denna spänning har varit påtaglig, i synnerhet förhållandet mellan nationella åtgärder som syftar till att skydda miljön och allmänna bestämmelser som reglerar EU:s inre marknad. Med tiden har miljöskydd och hållbar utveckling blivit inteSince the early days of the European project the economic rationale of integration has been confronted by public interests such as concerns for the environment. This tension has been tangible particularly in the relationship between national measures aimed at protecting the environment and the general rules governing the internal market. Over time environmental protection and sustainability have b

Ångcentralen på AAK har 4 olika pannor och huvudpannan är en biobränslepannan. Denna panna benämns även som Panna 4 och eldas idag med hushållspellets av klass A1. Vid förbränning så bildas kväveoxider, NOX, som har en negativ effekt på miljön och människor. AAK som idag ligger under villkorsvärdet för utsläpp av kväveoxider enligt krav från Förordning 2013:252 som gäller för stora förbränningsanlThe steam power station at AAK has 4 different boilers and the main boiler is a biofuel boiler. The boiler uses household pellets of type A1. During combustion, nitrogen oxides, NOX, are formed and they have many negative effects on the environment and has direct and indirect effects on human health. Today AAKs NOX emission are lower than the restricted regulation value for nitrogen oxide emission

The case study in focus for this research is the Women’s Strike in Poland movement during its articulation in late 2020. This movement was organized to campaign for reproductive rights and women’s rights in Poland after a restrictive abortion law was proposed in 2016, put into motion in 2020, and passed in 2021. This is an example of a contemporary movement supporting body autonomy and gender equa

Libraries of things, non-for-profit physical spaces where people borrow objects they would otherwise buy, have spread over Europe, the U.S., and Canada and have now emerged in Mexico City, where challenges to sustainability such as increased consumption levels and insufficient waste management abound. Collaborative economy initiatives like libraries of things are exposed as more sustainable altern

The Swedish Dementia Registry (SveDem) was developed with the aim to improve the quality of diagnostic work-up, treatment and care of patients with dementia disorders in Sweden.

A search for the Standard Model Higgs boson produced in association with a top-quark pair, , is presented. The analysis uses 20.3 fb(-1) of pp collision data at , collected with the ATLAS detector at the Large Hadron Collider during 2012. The search is designed for the decay mode and uses events containing one or two electrons or muons. In order to improve the sensitivity of the search, events are

Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is a prime laboratory animal for dissecting the genetics of T1D susceptibility without the need for exte

A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons,

This Letter reports on a first measurement of the inclusive W + jets cross section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC, with the ATLAS detector. Cross sections, in both the electron and muon decay modes of the W-boson, are presented as a function of jet multiplicity and of the transverse momentum of the leading and next-to-leading jets in the event. Measureme