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European oceans are in a poor state – only 10% of marine habitats and 2% of marine species show favourable conservation status. This is largely attributed to an intense pressure from industrial human activities at sea. The Marine Strategy Framework Directive (MSFD) from 2008 is an attempt to better protect marine environments in the European Union (EU) by enforcing an Ecosystem-Based Management (E
Background: Cancer of unknown primary (CUP) is a fatal cancer, accounting for 3-5% of all diagnosed cancers. Finding the primary site is important for therapeutic choices and we believe that the organ which is designated as the cause of death may give clues about the primary site. Methods: A total of 20,570 patients with CUP were identified from the Swedish Family-Cancer Database. Causes of death
Greece in a period of financial crisis (2008-2013) is questioning the success of its policy implementation. The training centers for the intellectually disabled, as implementers of policies and programs on a national and European level, also question that success. Using Foucault’s concept of power relations within society, it is aimed to find whether policies and programmes for the intellectually
The share of transport sector green house gas emissions has been increasing in the EU-15 in the recent decades. Moreover, the development in passenger and freight transport subsectors has diverged. This thesis provides drivers of freight transport carbon emissions in the EU-15 between 1995 and 2008 by conducting Log Mean Divisia Index (LMDI) decomposition. It differentiates between structure, inte
INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
From the early 1990s and onwards the use of debt relief as a method of providing development assistance has become increasingly popular, especially since the launch of the HIPC initiative in 1996. This thesis aims to investigate the general theoretical and empirical support of the growth enhancing properties of debt relief with regard to low income countries. Focus is put on evaluating the harmful
We introduced a reporter gene system into Pichia stipitis using the gene for the artificial green fluorescent protein (GFP), variant yEGFP. This system was used to analyse hypoxia-dependent PsADH2 regulation. Reporter gene activity was only found under oxygen limitation on a fermentable carbon source. The promoter was not induced by oxygen limitation in the Crabtree-positive yeast Saccharomyces ce
Context: The insulin tolerance test ( ITT) is the current standard diagnostic test for the diagnosis of adult GH deficiency ( GHD), but alternative tests, such as the GHRH- arginine test, have been proposed. Objective: We investigated the sensitivity and specificity of the GHRH- arginine test using ITT as the gold standard in diagnosing GHD in a group of young adults treated with cranial irradiati
Aims To investigate the role of guidelines in structuring the clinical care for adult patients with congenital heart disease (CHD), and to assess adherence to the guidelines in Europe. Methods and results A selected number of current guidelines were chosen pertaining to operative procedures, investigations, and the use of medication ('interventions'). The source for this analysis was the database
This study aims to identify the key leverage points of local tourism on Öland in which work can be initiated to bring about a more sustainable development of the tourism industry. To achieve this, an analysis was made of the tourism industry on Öland, and a methodological framework called The Öland Model developed for the initiation of a project to stimulate thinking among the actors on the island
Introduction: The scapular osseous free flap (SOFF) is being increasingly used for complex head and neck reconstructions. This study examined the surgical outcomes, focusing on post-operative complications and sequelae in patients who underwent SOFF for maxillary and mandibular reconstructions. Material and Methods: This retrospective, observational, population-based study included patients who un
BACKGROUND: Drug use Disorder (DUD), the risk for which is substantially influenced by both genetic and social factors, is geographically concentrated in high-risk regions. An important step toward understanding this pattern is to examine geographical distributions of the genetic liability to DUD and a key demographic risk factor - social deprivation.METHODS: We calculated the mean family genetic
Two mathematical models of human thermal regulation include the rational Predicted Heat Strain (PHS) and the thermophysiological model by Fiala. The approaches of the models are different, however, they both aim at providing predictions of the thermophysiological responses to thermal environments of an average person. The aim of this study was to compare and analyze predictions of the two models a
Calcite twinning in carbonaceous chondrite meteorites can be used to reconstruct the deformation history and the parent body environment during and/or after aqueous alteration, but the shock pressure threshold at which the twins develop is unknown. Accordingly, the aim of this study is to determine the magnitude of shock pressure that is needed to generate calcite twins. This was done by measuring
Radioactive iodine is commonly used for the treatment of different thyroid conditions since the 1940s. The EANM has developed a standard pre-therapeutic procedure to estimate patient specific thyroid uptake at treatment of benign thyroid diseases. The procedure which models the time dependent fractional thyroid uptake is based on a two-compartment fitting system, one representing the thyroid and t
Quality of life and health utility are important outcomes for patients with Alzheimer's disease (AD) and central for demonstrating the value of new treatments. Estimates in biomarker-confirmed AD populations are missing, potentially delaying payer approval of treatment. We examined whether health utility, assessed with the EuroQoL-5 3-level version (EQ-5D-3L), differed between individuals with a p
