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Photosynthetic Oxygen Evolution - EPR studies of the manganese cluster of photosystem II

Popular Abstract in Swedish Fotosyntesen är den mest grundläggande förutsättningen för människans överlevnad. Genom att absorbera solenergi och omvandla den till kemiskt bunden energi i form av energirika organiska molekyler, står fotosyntesen för nästan all tillförsel av energi till vårt ekosystem. Energin utnyttjas som mat, till oss och till djuren vi beror av, och som bränsle, fossilt eller färIn this thesis, a new electron paramagnetic resonance (EPR) signal from photosystem II is presented. The signal is shown to originate from the S0 oxidation state of the oxygen-evolving complex (OEC). It is a Mn-derived signal displaying clear hyperfine structure, centered at g=2, and is significantly broader than the well-known multiline signal from the S2 state, indicating the presence of MnII in

Compact fiber-optic fluorosensor using high-power continuous-wave violet diode laser

In this work a compact fluorosensor has been built for point-monitoring and imaging applications. The instrument has been applied in fluorescence studies on green vegetation and on malignant tissue. The instrument is based on a violet diode laser, an integrated spectrometer and optical fibers for light delivery and collection of the fluorescence signal. This combination makes the system very compa

Ptychographic Nano-Analytical Microscope (PtyNAMi) at PETRA III : Signal-to-background optimization for imaging with high sensitivity

The X-ray scanning microscope PtyNAMi at beamline P06 of PETRA III at DESY in Hamburg, Germany, is designed for high-spatial-resolution 3D imaging with high sensitivity. Besides optimizing the coherent ux density on the sample and the precision mechanics of the scanner, special care has been taken to reduce background signals on the detector. The optical path behind the sample is evacuated up unti

Low-Dose Oral Ketamine for Procedural Analgesia in Pediatric Cancer Patients Undergoing Lumbar Puncture at a Resource-Limited Cancer Hospital in India

Aim: The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting. Methods: Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a two-a

Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the t

Artificial intelligence together with mechanical imaging in mammography

Artificial intelligence (AI) applications are increasingly seeing use in breast imaging, particularly to assist in or automate the reading of mammograms. Another novel technique is mechanical imaging (MI) which estimates the relative stiffness of suspicious breast abnormalities by measuring the distribution of pressure on the compressed breast. This study investigates the feasibility of combining

GATA2 at the mitosis-to-G1 transition is critical for definitive hematopoiesis

In mitosis, transcription factors (TFs) and RNA polymerase disperse across the cytoplasm leading to transcriptional silencing, but some TFs are retained on condensed chromatin and mark genomic sites, a mechanism termed mitotic bookmarking. In pluripotent and differentiated cells this mechanism is important for pluripotency maintenance, cell reprogramming and lineage inheritance. However, the role

Recommendations for Deprescribing of Medication in the Last Phase of Life : An International Delphi Study

Context: Medications may become inappropriate for patients in the last phase of life and may even compromise their quality of life. Objective: To find consensus on recommendations regarding deprescribing of medications for adult patients with a life expectancy of six months or less. Methods: Experts working in palliative care or other relevant disciplines were asked to participate in this internat

Children with palliative care needs - the landscape of the nordic countries

BACKGROUND: To strengthen palliative care for children in the Nordic countries, an updated status of current needs, resources, clinical services, education, and research is necessary to align and consolidate future research. A Nordic research collaboration initiative for children with palliative care needs was assembled in 2023. Building on this initiative, this paper presents an overview of pedia

Only rare classical MHC-I alleles are highly expressed in the European house sparrow

The exceptional polymorphism observed within genes of the major histocompatibility complex (MHC), a core component of the vertebrate immune system, has long fascinated biologists. The highly polymorphic classical MHC class-I (MHC-I) genes are maintained by pathogen-mediated balancing selection (PMBS), as shown by many sites subject to positive selection, while the more monomorphic non-classical MH

The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CTLA-4 targeting therapies wit

Hävning av avtal enligt CISG – Särskilt om förhållandet mellan säljarens rätt att avhjälpa och köparens rätt att häva

One step in the pursuit of a harmonization of the rules regulating international sale of goods is the United Nations Convention on Contracts for the International Sale of Goods (CISG), which entered into force on January 1, 1988. As of today, 89 states have ratified the CISG and it is optional law for the majority of all contracts on the international sale of goods. A question highly debated at th

Extending the resolution of conventional deep seismic 3D surveys

Ny teknik på företaget Maersk Oil har möjliggjort en effektivare avbildning av den ytnära berggrunden som tidigare förblivit dolda. Denna nya metod leder förhoppningsvis till en mer säker kartläggning av geologiska risker. Ett viktigt framsteg där både liv och miljö kan sparas. Tänk dig en exploderande oljerigg, orsakat av att någon ovetandes borrat rakt in i en gasficka i den ytnära berggrunden.The main objective of this master's thesis is to evaluate a new processing method for extracting seismic conventional 3D streamer deep target data for shallow subsurface imaging. Deep target acquisitions have greater potential than it's conventional use. The aim of these acquisitions is to discover natural resources, in particular oil and gas, at several kilometres of depth. Before drillin

Science machines making futures

This chapter ". . . looks at a problem that is an important effect of systemic features: the problems of defining clear boundaries between different types of actors. Richard Langlais and Sharon Rider study the boundary between research performed by public universities and companies basing their technology on scientific research. They use the concept "science machines" to depict those systems of so

Relationship between somatostatin receptor expressing tumour volume and health-related quality of life in patients with metastatic GEP-NET

For patients with gastroenteropancreatic neuroendocrine tumours (GEP-NET), health-related quality of life (HRQoL) is important. Meanwhile, whether tumour volume is associated with HRQoL is unknown. Hence, the aim of this study was to assess if total somatostatin receptor expressing tumour volume is correlated with HRQoL in patients with metastatic GEP-NET. Some 71 patients were included in the stu