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Objective To assess the application of a quality control scheme for total prostate-specific antigen (PSA) as used for participants of the European Randomized Study for Screening of Prostate Cancer (ERSPC) during 1996-2002. Methods From 1996, the first complete year being 1997, an external scheme was organized by the Dutch Quality Assessment Foundation especially for the ERSPC. This scheme consists
Ser72 at the active site of the Escherichia coli dUTPase has been mutated to an alanine, and the properties of the mutant have been investigated. The serine is absolutely conserved among the monomeric and trimeric dUTPases (including the bifunctional dCTP deaminase:dUTPases), and it has been proposed to promote catalysis by balancing negative charge at the oxygen that bridges the alpha- and beta-p
PURPOSE: To determine the effect of radiotherapy in doses 14 to 20 Gy on eradication of carcinoma-in-situ (CIS) testis and on the Leydig cell function. PATIENTS AND METHODS: Forty-eight patients presented with unilateral testicular germ cell cancer and CIS of the contralateral testis. The CIS-bearing testis was treated with daily irradiation doses of 2 Gy, 5 days a week, to a cumulative dose of 20
New palaeomagnetic results for the 935 Ma Goteborg-Slussen mafic dykes in southern Sweden provide a well-dated high-quality palaeomagnetic pole for Early Neoproterozoic Baltica. New U-Pb geochronological data for several palaeomagnetically studied mafic intrusions yield three additional well-dated palaeopoles and one virtual geomagnetic pole. This set of dated poles suggests minimal drift of Balti
Musculoskeletal conditions often manifest with the onset of pain and the resulting physical limitations. Musculoskeletal pain is almost inevitable in in individual's lifetime. It is one of the most common reasons for self-medication and entry into the health care system. Musculoskeletal pain affects in 4 adults and is the Most commons Source of serious long-term pain and physical disability. The M
Although it is often assumed that birds strongly prefer tailwinds for their migratory flights, we predict that a strategy of no wind selectivity (traveling independently of winds) may be more favorable than wind selectivity (traveling on tailwind occasions but stopping to rest under headwind occasions) for birds with low energy costs of travel relative to rest and for birds that cannot use stopove
This article by the ESPGHAN Committee on Nutrition summarizes available information on the effects of adding prebiotic oligosaccharides to infant and follow-on formulae. Currently there are only limited studies evaluating prebiotic substances in dietetic products for infants. Although administration of prebiotic oligosaccharides has the potential to increase the total number of bifidobacteria in f
A shoreline to deep basin correlation chart for the middle Silurian coupled extinction-stable isotopic event is presented. The chart is a first attempt to synthesise new stratigraphic, faunal and stable isotopic data, as well as diversity changes among organic-walled microplankton (acritarchs), from the Grotlingbo-1 and Hunninge-1 cores on Gotland (Sweden), along with previously published data fro
Cutting tool spontaneous failure such as, edge fracture and chipping are common phenomena in the metal cutting process, especially when difficult workpiece materials which have poor cutibility are met in the machining process. The tool failures are often caused by high mechanical and thermal stresses acting in it. Monitoring stresses acting in a cutting edge during machining process can provide mo
A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoreti
During biosynthesis of bacteriochlorophyll or chlorophyll, three protein subunits of 140, 70, and 42 kDa interact to insert Mg2+ into protoporphyrin IX. The semi-dominant Chlorina-125,-157, and -161 mutants in barley are deficient in this step and accumulate protoporphyrin IX after feeding on 5-aminolevulinate. Chlorina-125,-157, and -161 are allelic to the recessive xantha-h mutants and contain G
We investigated whether renal function and microalbuminuria are independent predictors and whether any interaction exists between them, regarding future cardiovascular disease in hypertensive patients (n=10 881) followed for 4.5 years. The primary end points (PEs) were fatal and nonfatal myocardial infarction and stroke and other cardiovascular deaths. Creatinine and glomerular filtration rate (GF
Active duplicate PgiC genes in sheep's fescue, Festuca ovina, are associated with a PCR marker of specific length (about 370 bp, of which 231 are in an intron). Using this marker, the frequency of plants with duplicate genes is estimated to be about 10% in a population from southern Sweden. The close molecular similarity between the electrophoretically different duplicated genes is in accordance w
Timing of cirque formation and the climate necessary to initiate glaciation are fundamental to the understanding of the landscape of the northern Scandinavian mountains. Empty cirques in the Rassepautasjtjakka massif are located near a glaciated area and thus appear near the glaciation limit. In order to investigate the climate conditions necessary for glacier formation in the cirques, we applied
Abstract Background: Mass-weighted aerodynamic particle-size distribution (APSD) is a key attribute for pharmaceutical products developed to deliver drugs to or through the lungs. In development and quality control, APSD is primarily determined using multistage cascade impactors. For impactor techniques, particle reentrainment is critical because it may lead to an overestimation of the respirable
