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Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program

The Wilms tumor gene, WT1, encodes a zinc-finger DNA binding protein which is thought to function as a tissue specific transcription factor, regulating cell growth and differentiation. High expression of WT1 has been detected in a range of acute leukemias. To elucidate a role for WT1 in leukemogenesis, we transfected the monoblastic cell line U937, which lacks detectable levels of endogenous WT1,

Integrated modeling of submillimeter radio telescopes

Integrated models are inherently complex and often obscure to any but those who write them. Their usefulness can be greatly enhanced through well-structured, object-oriented design. A robust and computationally efficient Simulink/C++ library of optics, control, finite-element, and visualization routines for modeling radio telescope performance under various operating conditions is being developed

An integrated simulation model of the Euro50

The Euro50 is a proposed optical telescope with an equivalent aperture of 50 m. It will have a segmented primary mirror and full adaptive optics. To study the interaction of the telescope structure, the control system and the optics, an integrated simulation model has been formulated. The mechanical model is a modal version of an Ansys finite element model. The optics model is based on ray tracing

"Jag söker ett värdelöst guld/ ett guld som gör värdelöst/ guldet, allt guld!" : några ingångar till den litterära värdediskurens labryrint

This article examines the modern concept of literary value. Since the late 18th century, the problem of literary value has been regarded, from the point of view of the so called double discourse of value, as a presupposed opposition between material and spiritual ”economies”. Many Romanticist and Modernist authors believe that literature – and in a broader sense art and aesthetics – constitute a v

MRI assessment of haemophilic arthropathy

Popular Abstract in Swedish Blödarsjuka (hemofili) är en recessiv genetisk sjukdom orsakad av en defekt i X-kromosomen som leder till förlängd koagulationstid på grund av brist eller avsaknad av koagulationsfaktorerna VIII eller IX i blodet. Kvinnor är anlagsbärare, medan män utvecklar symptom. Hemofili förkommer sporadiskt som följd av spontan mutation likaväl som ärftligt inom vissa släkter, ochHaemophilia is a recessive genetic bleeding disorder in which coagulation time is prolonged due to the absence or malfunction of either of the serum proteins Factor VIII or IX. Joint destruction following repeated haemarthroses is the main cause of morbidity in haemophiliacs, and such arthropathy can be prevented or postponed by implementing prophylactic therapy with factor concentrate at an early

Self tuning cylinder pressure based heat release computation

The paper describes a novel method for self tuning cylinder pressure based heat release computation that is suitable for online usage in e.g. combustion phasing control applications. The method estimates the polytropic exponents and cylinder pressure offsets immediately preceding and succeeding the combustion event respectively using a fast nonlinear least squares method. The polytropic exponent a

Shape Modeling by Optimising Description Length Using Gradients and Parameterisation Invariance

In Statistical Shape Modeling, a dense correspondence between the shapes in the training set must be established. Traditionally this has been done by hand, a process that commonly requires a lot of work and is difficult, especially in 3D. In recent years there has been a lot of work on automatic construction of Shape Models. In recent papers (Davies et al., Medical Image Computing and Computer-Ass

The Use of Quotations in Discourse about Ethnicities

Examples from Czech and Swedish conversations illustrate how conversationalists use quotations when they define their own identity and when they speak about the identity of the others. The analysis is based on Tannens concept of constructed dialogue where direct quotation is seen as the creation of the speaker rather than the party quoted. The results indicate that quotations can be used strategic

Samverkansbroschyr a5

Att utveckla ett strukturerat samverkansarbete Diskussionsunderlag och orientering SAMHÄLLSVETENSKAPLIGA FAKULTETEN | LUNDS UNIVERSITET Innehåll Förord .........................................................................................5 Varför denna skrift? ..................................................................6 Hur kan den här skriften användas? .................................

https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/2021-01/samverkansbroschyr_a5.pdf - 2026-06-19

Fundamental review of the trading book - The new approach to measure market risk

The Fundamental Review of the Trading Book sets the standard for the most recent regulatory framework for minimum capital requirement within market risk. It will be implemented gradually up until 2019 and will overhaul a major part of the current regulation. More specifically it will cause financial institutions to estimate risk with Expected Shortfall instead of Value-at-Risk and add a new way of

It is also about health: an analysis of the CRPD Committee practice in light of southern epistemologies

The right to health for persons with disabilities in the global South is far from being realized. The 2011 World Report on Disability suggests that the majority of persons with disabilities live in low- and middle-income countries. Further studies suggest that around 80% of persons with disabilities in global South countries report poor health. With this in mind, this thesis will focus on the righ

Störningar i Stockholms järnvägstrafik på grund av obehöriga vid spår

Järnvägen utgör grunden för pendeltrafiken inom region Stockholm och störningar i järnvägstrafiken påverkar många resenärer. En vanlig orsak till störningar i järnvägstrafiken är att obehöriga personer vistas vid spåren. Mellan 2010-01-01 och 2015-05-18 har närmare 1100 händelser med obehöriga vid spår rapporterats i region Stockholm, varav drygt 80 fall resulterat i personpåkörningar med dödligt The railway constitutes the foundation of commuting in the region of Stockholm and disruptions in the railway traffic hence affects a lot of citizens. A common cause of disruptions is railroad trespassing and between 2010-01-01 and 2015-05-18 more than 1100 cases were reported in the region of Stockholm. The aim of this report is to map the grounds for railroad trespassing and to find measures to