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Protein kinase C (PKC) isoforms have been reported to be targeted to the Golgi complex via their C1 domains. We have shown recently that the regulatory domain of PKCtheta induces apoptosis in neuroblastoma cells and that this effect is correlated to Golgi localization via the C1b domain. This study was designed to identify specific residues in the C1 domains that mediate Golgi localization. We dem
A method of correcting the asymmetry in the scattering of the tangential beam configuration in a rheo-small-angle neutron scattering experiment is proposed. The asymmetry of the scattering in the tangential beam configuration can be attributed to the difference in pathlength for neutrons that are scattered toward compared with those which are scattered away from the axis of rotation of the shear c
To assess the value of ECG-gating for the diagnosis of myocardial infarction using myocardial perfusion scintigraphy (MPS) and an artificial neural network. A total of 422 patients referred for MPS were studied using a one day Tc-99m-tetrofosmin protocol. Adenosine stress combined with submaximal dynamic exercise was used. The images were interpreted by one of three experienced clinicians and thes
Cation exchange chromatography has been routinely used for the quantification of monoclonal antibody (mAb) charge heterogeneity. A previously developed method utilizing pH gradients for the elution instead of salt gradients was validated according to current guidelines proposed by the ICH. The linearity, stability, accuracy, precision and the lower limit of quantification have been determined, usi
Vacuum-assisted wound closure (VAC) therapy may heal wounds faster than conventional dressings after surgical debridement of perivascular groin infections after vascular surgery.
A search is presented for heavy-quark pair production (Q (Q) over bar) under the decay hypothesis Q (Q) over bar -> W(+)qW(-)(q) over bar with q = d, s, b for up-type Q or q = u, c for down-type Q. The search is performed with 1.04 fb(-1) of integrated luminosity from pp collisions at root s = 7 TeV collected by the ATLAS detector at the CERN LHC. Dilepton final states are selected, requiring larg
The aim of this study was 1) to investigate interfraction set-up uncertainties for patients treated with respiratory gating for left-sided breast cancer, 2) to investigate the effect of the inter-fraction set-up on the absorbed dose-distribution for the target and organs at risk (OARs) and 3) optimize the set-up correction strategy. By acquiring multiple set-up images the systematic set-up deviati
This paper offers an analysis of a case of cooperation, and in particular cooperation problems, between independent performing arts organisations in the region of Skåne, Sweden. The cooperation in question flows from visions of the organisations, and linked regional commission to develop the infrastructure and networks of the independent performing arts in Skåne. The case gives evidence of the cha
Report of a trans-european research project that has taken place over two years (1999 – 2001) involving 15 partners from 10 EU countries, one EFTA and one non-EU country, and a European federation. On the basis of empirical and conceptual work the project proposes a common framework for education and training with a duration of six years. It is intended to be used to: Assess the adequacy of existi
The challenges for creating a greener economy and the institutional framework for sustainable development pass necessarily, or mostly, through cities, as they concentrate a large and growing part of the world’s economy and population, as well as decision-making power. With the processes of urbanization and rural-urban transformation, the economy in cities, especially in cities of developing countr
In the last decade 3D technologies have become a very effective means for managing and interpreting archaeological data. A better way to perceive, understand and communicate Cultural Heritage has been achieved through VR applications, which have enabled archaeologists both to make reconstructions of original landscapes and to put artifacts in their original context. Furthermore, the astonishing gr
Objective: To validate the prediction model for successful vaginal birth after cesarean delivery (VBAC) based on variables easily obtainable at the first antenatal visit, in a Spanish population. Methods: Retrospective observational study. Women with a single live fetus in cephalic presentation with one previous low-transverse CD who underwent trial of labor after cesarean delivery (TOLAC) at ≥37
Kinetic model studies and control analyses of the Calvin photosynthesis cycle have been performed to characterize the dependence of the cycle activity on maximum velocities and Kmvalues for the interaction of the non‐equilibrium cycle enzymes and ATP synthetase with their substrates under conditions of light and carbon dioxide saturation. The results show that Km values have no major influence on
A novel Stacked Multi-Level (SML) modulator topology optimized for long pulse and high average power applications has been developed at ESS. It utilizes six identical modules connected in series at the HV output side and fed in parallel from the low voltage side. Each one is formed by one HF inverter, one step-up transformer, one HV rectifier bridge and one HV passive filter. They are supplied, in
Shortcomings of current techniques used for the intracerebral transplantation of ventral mesencephalic dopamine neurons include low graft survival, high variability, considerable implantation trauma and suboptimal graft integration. In order to overcome these limitations, we have adopted a microtransplantation approach which allows precise and reproducible implantation of ventral mesencephalon cel
The FinEstBeaMS beamline is under construction at the 1.5 GeV storage ring of the MAX IV Laboratory at Lund, Sweden. It has been designed to cover an unusually wide energy range from ultraviolet (4.3 eV) to soft X-rays (1000 eV) but experiments will also be possible at the Mg and Al Kα energies. Instead of having two different insertion devices and optical schemes for low and high photon energy re
Previous studies about the trends and sources of PV soft cost reduction have only offered a limited understanding of systemic aspects that drive this development. Drawing on concepts of sectoral innovation system theory, this study analyzes the evolution of the German PV sectoral system since the early 1990s, focusing specifically on key processes associated with the deployment of building-sited P
The advent of inexpensive consumer virtual reality equipment enables many more researchers to study perception with naturally moving observers. One such system, the HTC Vive, offers a large field-of-view, high-resolution head mounted display together with a room-scale tracking system for less than a thousand U.S. dollars. If the position and orientation tracking of this system is of sufficient acc
