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Melanoma remains the most aggressive form of skin cancer, characterized by high metastatic potential, genetic heterogeneity, and resistance to conventional therapies. The Melanoma MEGA-Study is a multi-center initiative designed to address these clinical challenges by integrating advanced proteogenomic profiling, clinical metadata, with AI-driven digital pathology and machine learning analytics, a

Alternative Economic Models (AEMs) are theoretical frameworks that, if implemented, could fundamentally transform economic systems by aligning financial objectives with sustainability goals. Conducting rigorous research on future-oriented AEMs and other complex sustainability systems presents challenges, particularly due to the exploration of largely unverifiable future possibilities. Qualitative

The article discusses the development and application of the so-called “stigma engagement strategy (SES)” in interviews with stigmatized study populations, drawing on an interview study with Swedish men who have paid for sex. SES is a qualitative methodological approach that utilizes external sources of stigmatizing narratives, such as newspaper articles and columns, as textual probes within inter

For exploring forest performance in the future, dynamic vegetation models are important tools. Tree mortality is a crucial process in these models, but explicit representations of major agents of mortality have often been relatively underdeveloped. In needle-leaved forest in the temperate and boreal zones, bark beetles are often important for the mortality pattern. The European spruce bark beetle

Populations are presumed to be adapted to local environmental conditions via natural selection, with gene flow breaking up local adaptations. In birds, various aspects of feathers may reflect local adaptation. For example, the insulation capacity of feathers could be greater in colder regions, while colour variation may also play a role in adapting to local environmental conditions since darker fe

Northern mires are significant natural sources of atmospheric methane (CH4), yet estimating CH4 emissions remains challenging due to their complex spatio-temporal dynamics. While eddy covariance (EC) measurements provide valuable insights into ecosystem-scale CH4 fluxes (FCH4) over mire areas typically < 0.05 km², the predictability of FCH4 at the mesoscale (∼0.5 – 20 km²) of a mire complex based

The paper deals with the notion of stability for thermo-elastoplastic materials undergoing large strains. The stability analysis is performed by using the perturbation approach applied to a comprehensive material model derived in a thermodynamic format. As the main contribution of this paper a stability condition for a material model incorporating geometrical and material non-linearities under ful

In this article, I identify a key trend for demarcating the “secular” as a Western, Christian achievement. I analyze how the New Testament story often known as “Render unto Caesar” is referenced as a source for the secular West, particularly in writings by European and American conservative thinkers in the 1990s and early 2000s. My argument is that these references to “Render unto Caesar” constitu

In recent decades, a significant advancement in the Global Navigation Satellite System (GNSS) has been adopting the vector tracking (VT) technique, particularly in environments where stable and reliable positioning is essential. It facilitates rapid reacquisition and continuous tracking of GNSS signals by linking the data processing and signal processing modules. In challenging environments affect

Objectives ‒ Chronic pain is a major global public-health issue. In Sweden, 20% adults report moderate to severe chronic pain, with 7% continuously seeking healthcare. Shortcomings in treatment, accessibility, and knowledge in healthcare for chronic pain have previously been reported. A generic treatment structure from primary to specialized care and rehabilitation was missing. This study aims to

□ Total hip arthroplasty (THA) registers are established in several countries to collect data aiming to improve the results after THA. Monitoring of adverse outcomes after THA has focused mainly on revision surgery, but patientreported outcomes have also been investigated. □ Several surgery-related factors influencing the survival of the THA have been thoroughly investigated and have changed clini

Childhood and adolescence are critical periods of neural development and physical growth. The malnutrition and related medical complications resulting from eating disorders such as anorexia nervosa (AN), bulimia nervosa (BN) and eating disorder not otherwise specified may have more severe and potentially more protracted consequences during youth than during other age periods. The consensus opinion

Many everyday activities, such as engaging in conversation or listening to a story, require us to sustain attention over a prolonged period of time while integrating and synthesizing complex episodic content into a coherent mental model. Humans are remarkably capable of navigating and keeping track of all the parallel social activities of everyday life even when confronted with interruptions or ch

In the present study, different model order reduction methods were compared in terms of their effects on the dynamic characteristics of individual building components. A wide variety of methods were employed in two numerical examples, both being models of wooden floor structures, in order to draw conclusions regarding their relative efficiency when applied to models of such structures. It was obse

Transcriptional profiling of acute leukemia, specifically by RNA-sequencing or whole transcriptome sequencing (WTS), has provided fundamental insights into its underlying disease biology and allows unbiased detection of oncogenic gene fusions, as well as of gene expression signatures that can be used for improved disease classification. While used as a research tool for many years, RNA-sequencing

A flow injection thermal microbiosensor was designed for the simultaneous determination of multiple analytes. The biosensor consisted of five thin-film thermistors which were located along a single microchannel. The device was fabricated on a quartz chip by micromachining. The feasibility of employing this system for the detection of two independent enzyme reactions was demonstrated using two diff