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Importance: While clinical disease stages remained largely unchanged in the 2024 update of the Alzheimer disease (AD) criteria, tau-positron emission tomography (PET) was introduced as a core biomarker and its spatial extent was incorporated into the revised biological stages of the disease. It is important to consider both the clinical and the biological stages and understand their discrepancies.
A search is presented for a heavy scalar (H) or pseudo-scalar (A) predicted by the two-Higgs-doublet models, where the H/A is produced in association with a top-quark pair (tt¯H/A), and with the H/A decaying into a tt¯ pair. The full LHC Run 2 proton–proton collision data collected by the ATLAS experiment is used, corresponding to an integrated luminosity of 139fb-1. Events are selected requiring
INTRODUCTION: Amyloid-induced tauopathy drives clinical decline in Alzheimer's disease (AD). Because age and sex shape tau trajectories, defining patient-centered amyloid thresholds for tauopathy onset could facilitate pre-tauopathy AD identification and aid treatment decisions and prognosis. METHODS: By including two samples (Alzheimer's Disease Neuroimaging Initiative [ADNI, n = 301]; and 18F-AV
The production of fast pyrolysis bio-oil (FPBO) from secondary biomass is a promising technique for the production of liquid biofuels. However, the resulting FPBO is often viscous and chemically unstable, requiring significant upgrading while also being difficult to work with. To overcome this issue, FPBO can be hydrotreated using slurry hydrotreatment, which has a long history as a processing tec
Public procurement has the potential to serve as a strategic driver for circular economy implementation and urban sustainability transitions. Purpose: This study explores how municipalities incorporate circular requirements into construction project procurement processes. The aim is to identify practical strategies that support circular implementation in construction projects. Methodology: U
This study explores the effectiveness of combining Electrical Resistivity Tomography (ERT) and Induced Polarization (IP) for identifying internal erosion processes in embankment dams. A small-scale test dam was built in Älvkarleby, Sweden, with deliberately embedded but undisclosed defects to test monitoring capabilities. Daily ERT and IP measurements were collected during 4.5-year years, and anal
This paper presents a two-phase heuristic methodology aimed at the reconfiguration of a radial distribution network with the objective of minimizing the computational time. In the preliminary phase of the operation, all network switches are in a closed state, and it is proposed that a subsequent switch opening methodology be employed to achieve a configuration that approximates optimal radial char
PURPOSEThe aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) -related bone disease.MethodologyAn interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published data through August 2012. Expert consensus was used to propose additional recommendations in situation
Childhood and adolescence are critical periods of neural development and physical growth. The malnutrition and related medical complications resulting from eating disorders such as anorexia nervosa (AN), bulimia nervosa (BN) and eating disorder not otherwise specified may have more severe and potentially more protracted consequences during youth than during other age periods. The consensus opinion
Many everyday activities, such as engaging in conversation or listening to a story, require us to sustain attention over a prolonged period of time while integrating and synthesizing complex episodic content into a coherent mental model. Humans are remarkably capable of navigating and keeping track of all the parallel social activities of everyday life even when confronted with interruptions or ch
In the present study, different model order reduction methods were compared in terms of their effects on the dynamic characteristics of individual building components. A wide variety of methods were employed in two numerical examples, both being models of wooden floor structures, in order to draw conclusions regarding their relative efficiency when applied to models of such structures. It was obse
Consider the random graph on n vertices 1,...,n. Each vertex i is assigned a type x(i) with x(1),...,x(n) being independent identically distributed as a nonnegative random variable X. We assume that EX3 < infinity. Given types of all vertices, an edge exists between vertices i and j independent of anything else and with probability min{1, x(i)x(j)/n (1 + a/n(1/3))}. We study the critical phase, wh
The ROAdmap for MEntal health Research in Europe project aimed to create an integrated European roadmap for mental health research. Leading mental health research experts across Europe have formulated consensus-based recommendations for future research within the public mental health field.
Despite the ban by the European Union, anabolic steroids might still be illicitly employed in bovine meat production. The surveillance of misuse of such potentially harmful molecules is necessary to guarantee consumers' health. Analytical methods for drug residue control are based on LC-MS/MS, but their efficacy can be hindered due to undetectable residual concentrations as a result of low-dosage
We have studied the homolytic dissociation of a methyl radical from a model of methyl cobalamin. For this reaction, density functional theory with an atom-pairwise dispersion correction (DFT-D) gives a dispersion contribution to the bond dissociation energy (BDE) of 22-51 kJ mol(-1) depending on the functional, i.e. much more than common estimates for the total dispersion interaction energy of the
Biofuels for transport are attracting considerable support from the European Union. However, the complexity of the biofuels industry and the diversity of actors create significant challenges for policy-making and governance. This paper explores the role of governance in the development of the biofuels industry in Europe focusing on Sweden and the UK. The purpose of this paper is to investigate the
