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Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely
Objective:To assess the importance of MAPT variant p.A152T in the risk of synucleinopathies. Methods:In this case-control study, we screened a large global series of patients and controls, and assessed associations between p.A152T and disease risk. We included 3,229 patients with clinical Parkinson disease (PD), 442 with clinical dementia with Lewy bodies (DLB), 181 with multiple system atrophy (M
The paper reports a study involving the use of Halomonas boliviensis, a moderate halophile, for co-production of compatible solute ectoine and biopolyester poly(3-hydroxybutyrate) (PHB) in a process comprising two fed-batch cultures. Initial investigations on the growth of the organism in a medium with varying NaCl concentrations showed the highest level of intracellular accumulation of ectoine (0
Technical infrastructures of the society are becoming more and more interconnected and interdependent, i.e. the function of an infrastructure influences the function of other infrastructures. Disturbances in one infrastructure therefore often traverse to other dependent infrastructures and possibly even back to the infrastructure where the failure originated. It is becoming increasingly important
Carbon dioxide (CO2) measurement is a fundamental evaluation in a neonatal intensive care unit (NICU), as both low and high values of CO2 might have detrimental effects on neonatal morbidity and mortality. Though measurement of CO2 in the arterial blood gas is the most accurate way to assess the amount of CO2, it requires blood sampling and it does not provide a continuous monitoring of CO2.
This paper reports on design studies concerning a moderator concept which aims to maximize the time averaged flux. The idea is to provide neutron spectra showing two clear maxima, with peaks at (similar to 1 angstrom) and (similar to 2.5 angstrom) arising from leakage from both cryogenic and thermal moderators. Such a concept known as a bi-spectral moderator (Mezei, 2006 [1]) while proven on a rea
Coordination during disaster recovery is one of the most neglected areas of disaster risk management, as the majority of literature on coordination focuses on disaster response. The purpose of the study is to investigate the factors affecting coordination for long-term recovery. For this purpose, the study uses semi-structured interviews with different actors involved in the recovery process of th
Objectives: To develop European League Against Rheumatism (EULAR) recommendations for the management of small and medium vessel vasculitis. Methods: An expert group ( consisting of 10 rheumatologists, 3 nephrologists, 2 immunologists, 2 internists representing 8 European countries and the USA, a clinical epidemiologist and a representative from a drug regulatory agency) identified 10 topics for a
Partially premixed combustion has the potential of high efficiency and simultaneous low soot and NOx emissions. Running the engine in PPC mode with high octane number fuels has the advantage of a longer premix period of fuel and air which reduces soot emissions, even at higher loads. The problem is the ignitability at low load and idle operating conditions. The objective is to investigate the use
A set of three dedicated triggers designed to detect long-lived neutral particles decaying throughout the ATLAS detector to a pair of hadronic jets is described. The efficiencies of the triggers for selecting displaced decays as a function of the decay position are presented for simulated events. The effect of pile-up interactions on the trigger efficiencies and the dependence of the trigger rate
The scope of this paper is to test the predictive capabilities of different evacuation modelling approaches to simulate tunnel fire evacuations. The study is based on the a priori modelling (prior to the experiments) vs a posteriori modelling (after the data collection stage) of a set of tunnel evacuation experiments performed in a tunnel in Stockholm, Sweden. Different degrees of modelling sophis
Popular Abstract in Swedish Mögel i byggnader är ett vanligt problem som kan orsaka en dålig innemiljö och påverka hälsan hos de personer som vistas i byggnaden. Kostnaderna för att åtgärda problemen kan vara omfattande. Att redan vid planeringsstadiet av en byggnad ta hänsyn till risker för mögelväxt kan leda till minskat antal mögelskador i framtiden och ett mer hållbart byggande. Mögelväxt är The susceptibility to mould growth varies between building materials. The factors that most affect mould growth, the relative humidity (RH) and temperature also vary in different parts of buildings. One way of preventing the growth of mould in buildings is therefore to choose building materials that can withstand the expected conditions. It is thus crucial that data are available to allow the corr
Single photons detected by the DELPHI experiment at LEP2 in the years 1997-2000 are reanalysed to investigate the existence of a single extra dimension in a modified ADD scenario with slightly warped large extra dimensions. The data collected at centre-of-mass energies between 180 and 209 GeV for an integrated luminosity of similar to 650 pb(-1) agree with the predictions of the Standard Model and
Purpose Timely knowledge of the bacterial etiology and localization of infection are important for empirical antibiotic therapy. Thus, the goal of this study was to evaluate routinely used biomarkers together with novel laboratory parameters in the diagnosis of infection. Methods In this prospective study, 54 adult patients with bacterial infections admitted to the Department of Infectious Disease
The objective was to develop evidence -based recommendations and a research and educational agenda for the non-pharmacological management of hip and knee osteoarthritis (OA). The multidisciplinary task force comprised 21 experts: nurses, occupational therapists, physiotherapists, rheumatologists, orthopaedic surgeons, general practitioner, psychologist, dietician, clinical epidemiologist and patie
The beverage packaging industry is growing rapidly, driven by urbanization and changing lifestyles. Demand for packaged beverages with extended shelf life is driving sales of products with superior barrier properties, due to the high environmental impact of food waste compared to packaging waste. Despite progress, packaging waste represents more than a third of total waste. Thus, milk and plant-ba
This thesis presents a case for the establishment of a human right to financial inclusion under the human rights framework, as well as argues for states to legitimize the right through legal protection in the form of a legislation in order to effectively guarantee the significant benefits of the right for everyone. The rationale for this research is that, despite its immense contribution in human
Glioblastoma is a highly aggressive brain tumor that kills roughly 9,000 Americans yearly. Although a known disease for over a century, little progress has been made in treatment development. A breakthrough may be on its way as recent research suggests glioblastoma patients can be treated with virus injections, oncolytic virotherapy in medical terms. However, this treatment method is somewhat inhi
Sustainable development requires collaboration between governments, businesses, and citizens. However, economic models, sustainability practices, and global policies are currently not fit-for-purpose to maintain global temperatures to 1.5 degrees centigrade within the timescales required to maintain a safe space for humanity to thrive. This study maps the alignment of business values and practices
