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Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association Diabetes Care 2015;38:1964–1974 | DOI: 10.2337/dc15-1419 The Adoption of the Staging Classification System Is Endorsed by the American Association of Clinical Endocrinologists, the International Society for Pediatric and Adolescent Diabetes, and The Leona M. and Harr
https://www.gppad.lu.se/sites/gppad.lu.se/files/2025-05/T1D_staging.pdf - 2026-05-30
Journal of Parkinson’s Disease 11 (2021) 515–528 DOI 10.3233/JPD-202366 IOS Press 515 Research Report Grafts Derived from an -Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson’s Disease Shelby Shrigleya,b, Fredrik Nilssona,b, Bengt Mattssona, Alessandro Fiorenzanoa,b, Janitha Mudannayakea,b, Andreas Bruzeliusa,b, Da
AI och framtidens ledarskap Utmaningar väntar dekaner På plats i Kungshuset Lever historia NU ÄR DICK HARRISON UTE MED BOK NR 105 LUNDS UNIVERSITETS MAGASIN | NR 1 | 2024 2 LUM NR 1 | 2024 LUM NR 1 | 2024 3 Humanistlaboratoriet har fått allt större betydelse för forskningen inom humaniora, både vid Lunds universi- tet och nationellt. En kraftig ökning av nya användare de senaste åren och stora for
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-02/LUM%201%202024.pdf - 2026-05-30
Objectives: To investigate the importance of birth characteristics and early life infections on the risk of later rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). Methods: A nationwide register-based case-control study was performed based on prospectively recorded data on individuals born in 1973 or later. Using the Swedish inpatient register and the early arthritis register, cas
Background: The global gene regulator Special AT-rich sequence-binding protein1 (SATB1) has been reported to reprogramme tumour cells into a more malignant phenotype and associate with poor clinical outcome in several cancer forms. In this study, we investigated the molecular correlates and prognostic impact of SATB1 expression in human epithelial ovarian cancer (EOC). Findings: Immunohistochemica
One of the most common methods of inducing stress in the laboratory in order to examine the stress response in healthy and clinical populations is the Trier Social Stress Test (TSST). Briefly, the participant is asked to deliver a speech and to perform an arithmetic task in front of an evaluating committee. The committee, consisting of three trained actors, does not respond emotionally during the
In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated with a very poor prognosis. In order to ascertain whether the frequencies and patterns of submicroscopic changes, identifiable with single nucleotide polymorphism array analysis, differ between childhood and adult acute lymphoblastic leukemia, we performed single nucleotide polymorphism array analys
Objective To assess the use of lipid-lowering therapy in patients with known coronary heart disease (CHD), cerebrovascular disease or diabetes in a community-based population in Sweden considering expert recommendations. Methods A random sample of individuals aged >= 40 years who were surveyed in 1993-1994 were revisited 10 years later during 2003-2004 (n=724). A clinical investigation focused on
Background: Studying contemporary hybridization increases our understanding of introgression, adaptation and, ultimately, speciation. The sister species Ischnura elegans and I. graellsii (Odonata: Coenagrionidae) are ecologically, morphologically and genetically similar and hybridize. Recently, I. elegans has colonized northern Spain, creating a broad sympatric region with I. graellsii. Here, we r
Background: The prevalence of blindness and visual impairment from glaucoma is influenced by the criteria used to define these entities, which differ between countries and regions, as well as among published reports. The objective of the present study was to ascertain the extent to which different criteria of blindness and visual impairment influence estimates of the number of patients classified
Even though a number of studies have shown that UV-B radiation inhibits plant growth and regulates the cell cycle progress, little is known about the molecular and cellular mechanisms. Here, we developed a synchronous root-tip cell system to investigate expression changes of cell cycle marker genes and DNA damage under UV-B radiation. Expression analysis of cell cycle marker genes revealed that G1
Abstract Background. Proteinuria is the hallmark of glomerular disease and non-selective proteinuria is often associated with progression to renal failure. The predictive value of urine IgG excretion was studied comprehensively in patients with nephrotic syndrome. In the present follow-up study, we examine the predictive value of IgG-uria in patients with idiopathic glomerular diseases with a wide
Background: The natriuretic peptides play an important role in salt homeostasis and blood pressure regulation. It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown. Aim: The aim of this study was to examine the association between obesity and natriuretic peptide levels and evaluate the
The formation of aluminides during the heating of Nb-Al powder mixtures with different initial compositions (25, 33.3 and 75 at.% Al) has been studied using a differential scanning calorimeter. The effect of parameters like particle size, compaction and heating rate on the onset temperature of reaction has been determined. The results show that an increase in heating rate leads to an increase in o
Apolipoprotein M (apoM) is composed of 188 amino acids and has an apparent molecular weight of 25 kDa. ApoM belongs to the lipocalin protein superfamily, and is found in all major lipoprotein classes, although the majority of apoM is found in high density lipoprotein, HDL. In apoM, the signal peptide is retained in the mature protein. ApoM with a cleavable signal peptide was constructed. In contra
PURPOSE. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. METHODS. Subjects with OAG were identified in nine surveys of randomly sampled populations using standard criteria for glaucomatous optic neuropathy. Subjects were of European, African, Chinese, and Hispanic ethnicity. The measure of OAG dama
Objective. To examine the appropriateness and necessity of colonoscopy across Europe. Design. Prospective observational study. Setting. A total of 21 gastrointestinal centers from 11 countries. Participants. Consecutive patients referred for colonoscopy at each center. Intervention. Appropriateness criteria developed by the European Panel on the Appropriateness of Gastrointestinal Endoscopy, u
Popular Abstract in Swedish Svenska knäplastikregistret och knäledsoperation med enkammarprotes av Stefan Lewold Ledsjukdom, oftast artros, är den vanligaste kroniska åkomman hos äldre. Dess orsak är oftast inte känd och någon förebyggande behandling finns inte. Icke operativ behandling kan i tidiga stadier dämpa symptomen men då sjukdomen fortskrider får patienten allt svårare att klara sig. GenThe Swedish Knee Arthroplasty study has prospectively registered and followed knee arthroplasties done in Sweden since 1976. Demography, epidemiology and general knee prosthetic biofunction is given for 30,003 primary knee arthro-plasties and their revisions through 1992. The annual number of knee arthroplasties increased fourth fold while the relative use of Unicompartmental knee arthroplasty (UK
Introduction Chronic rejection (CHR) of organ allografts, one of the most significant problems in modern transplantation, is not fully understood. This study sought to evaluate the influence of selected parameters on late kidney transplant function. Patients and Method The studied group consisted of eighty-six patients who received allogeneic transplants between 1988 and 1999 for leukocyte Chlam
