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Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history
Our aim was to study how breast density relates to tumor characteristics in breast cancer with emphasis on mode of detection. Among 17,035 women in the Malmö Diet and Cancer Study 826 incident cases have been diagnosed (1991-2007). Data on tumor characteristics, mode of detection, and density at diagnosis were collected. Associations between density and tumor characteristics were analyzed using lo
Four green microalgae (Chlorella sorokiniana, Chlorella vulgaris, Scenedesmus obliquus and Selenastrum capricornutum), a wild Bolivian microalga strain and two cyanobacteria (Anabaena catenula and Microcystis aeruginosa) were compared for tolerance to salicylate, O2 production capacity and ability to support salicylate degradation by a Ralstonia basilensis strain in symbiotic microcosms with the m
Compensation behaviour is established for the gas phase hydrodehalogenation of a range of haloarenes over a common Ni/SiO2 catalyst. Analysis of the experimental results delivers an isokinetic temperature (T-iso) at 658 +/- 2K associated with the following reactants: chlorobenzene, 4-chlorotoluene, 3-chlorophenol, 1,3,-dichlorobenzene, 4-chlorophenol, 3,5-dichlorophenol, 1,4-dichlorobenzene, bromo
Protein E (PE) is a ubiquitous multifunctional surface protein of Haemophilus spp. and other bacterial pathogens of the Pasteurellaceae family. H. influenzae utilizes PE for attachment to respiratory epithelial cells. In addition, PE interacts directly with plasminogen and the extracellular matrix (ECM) components vitronectin and laminin. Vitronectin is a complement regulator that inhibits the for
In this paper, we analyze the potentials of a four-phase 14-GHz CMOS voltage-controlled oscillator, tailored to a sub-harmonic receiver, for signal processing at Ka-band. When mild phase accuracies between in-phase and quadrature down-converted signals are required, the four-phase oscillator displays roughly the same phase noise figure-of-merit as quadrature oscillator counterparts. However, the o
This study was undertaken in order to compare regional cerebral blood now (rCBF) and EEG findings of patients with clinically diagnosed dementia with Lewy bodies (clinDLB) and Alzheimer’s disease (clinAD). Furthermore, within the clinDLB group to compare cases with and without neuropathologically verified Lewy bodies (LBs). When we studied 200 dementia cases in a prospective longitudinal dementia
Erythropoietin (Epo) has been used in the treatment of anemia resulting from numerous etiologies, including renal disease and cancer. However, its effects are controversial and the expression pattern of the Epo receptor (Epo-R) is debated. Using in vivo lineage tracing, we document that within the hematopoietic and mesenchymal lineage, expression of Epo-R is essentially restricted to erythroid lin
AI-modellen ChatGPT har blivit omåttligt populär på kort tid och används dagligen av miljontals människor. Genom att analysera stora mängder data bestående av offentlig information utför AI-modellen tjänster som CVskrivande, diktkomponerande och besvarande av frågor om allt från vetenskap, till kultur och historia. ChatGPT används i mycket stor utsträckning, trots att den genererade informationen The AI model ChatGPT has become immensely popular in a short time and is used daily by millions of people. By analyzing large amounts of data consisting of public information, the AI model performs services such as CV writing, composing poems and answering questions about everything from science, to culture and history. ChatGPT is used to a very large extent, despite the fact that the generate
How we choose to invest in the future generations is becoming increasingly imperative as researchers learn more about the long-term consequences of early childhood. The early-life literature suggests that empowered mothers invest more into their children and that matrilineal females are more empowered than patrilineal counterparts. To further understand the role of female empowerment on early chil
Fitnesskulturen växte fram i USA och blomstrade under 1970-talet men har sedan dess spridit sig över hela världen. Idag hålls tävlingar och evenemang inom fitness i Sverige och fitnessbranschen växer sig större. Användningen av dopingpreparat förekommer i alla sporter och även inom fitnessbranschen. Den tidigare forskningen visar på studier som tar upp dopingpreparat som problem men i kontexten fi
In this work, two LNAs operating at a frequency around 83 GHz and 110 GHz, for satellite- and 5G applications respectively, have been designed, using vertical InGaAs nanowire transistors. In addition, a switch operating at a frequency around 110 GHz has been designed. The topology has consisted of a common source as a first stage, and a cascode as a second stage. The design and simulations of the
Examensarbetet är utfört vid Lunds Tekniska Högskola, avdelningen för Teknisk Geologi i samarbete med Vattenfall Research and Development AB, med syfte att undersöka åldringsfenomen och nedbrytningsprocesser av kraftverkstunnlar i berg. Livslängden för kraftverkstunnlar antas normalt vara mellan 50 och 100 år, varför många kraftverkstunnlar idag uppnått en ålder på mer än 50 år. Kraftverkstunnlar
Att diagnostisera en hörselnedsättning och inleda habilitering så tidigt som möjligt på små barn har visat sig vara av stor betydelse. Genom åren har flera olika diagnostiska metoder utvecklats får att kunna utföra hörselmätningar på små barn. I Linköping utarbetades 1996 ett datorstött mätsystem för barnaudiometri. Systemet är en variant av tittlådeaudiometri, Visual Reinforcement Audiometry (VRA
