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Syftet med avhandlingen var att undersöka och utvärdera bindningen av molekyler mot ett målprotein som är involverad i tillväxten av cancerceller. Undersökning genomfördes på Red Glead Discovery med WAC (weak affinity chromotography) som är en kromatografisk separationsmetod, där molekyler med olika vikt pumpas genom olika kolonner och retentionstiden för molekylerna i kolonnen detekteras. MolekylThe drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been impleme

This paper provides a comprehensive overview of quantile-parameterized distributions (QPDs) as a tool for capturing expert predictions and parametric judgments. We survey a range of methods for constructing distributions that are parameterized by a set of quantile-probability pairs and describe an approach to generalizing them to enhance their tail flexibility. Furthermore, we explore the extensio

Deposition of ferroelectric hafnium zirconium oxide (HZO) on semiconductor samples with Atomic Layer Deposition (ALD) has proven to be a viable method of production. But while the physical processes of ALD deposition is relatively well know, there exists some gaps in knowledge about different parameters for the ALD and the resulting depositions. This work is about analysing mainly how the purge ti

Purpose: The purpose of this paper is to investigate how modern network video technology could be used to improve different warehouse types and operations and how barriers may prevent its implementation. Design/methodology/approach: An exploratory multiple-case study with nine case companies was conducted, including on-site visits, interviews, questionnaires and a workshop. Findings: The authors i

Subarctic ecosystems are predicted to experience the fastest responses to climate change on the planet, with dramatically altered vegetation patterns, frost dynamics and hydrological flow paths. The resulting change in dissolved organic carbon (DOC) export to river systems is poorly known, but reports of rising DOC in northern surface waters have led to widespread speculations on a possible climat

Climate change projections show that temperature and precipitation increases can alter the exchange of greenhouse gases between the atmosphere and high latitude landscapes, including their freshwaters. Dissolved organic carbon (DOC) plays an important role in greenhouse gas emissions, but the impact of catchment productivity on DOC release to subarctic waters remains poorly known, especially at re

The density of roots is an important factor influencing the rate and magnitude of landslides. Due to the increased variability in climate, mainly rainfall, Eastern Uganda is severely struck by an increasing number of these mass movements, often with human casualties as one of the negative impacts. The aim of this study is to explore the possibility to estimate the depth and density of the root sys

Global gridded crop models (GGCMs) combine agronomic or plant growth models with gridded spatial input data to estimate spatially explicit crop yields and agricultural externalities at the global scale. Differences in GGCM outputs arise from the use of different biophysical models, setups, and input data. GGCM ensembles are frequently employed to bracket uncertainties in impact studies without inv

Increasing aridity is one major consequence of ongoing global climate change and is expected to cause widespread changes in key ecosystem attributes, functions, and dynamics. This is especially the case in naturally vulnerable ecosystems, such as drylands. While we have an overall understanding of past aridity trends, the linkage between temporal dynamics in aridity and dryland ecosystem responses

Background: Previous research has shown that men who have sex with men (MSM) avoid formal healthcare services because of the fear of discrimination as homosexuality is illegal and stigmatized in Tanzania. Instead, self-treatment by medications obtained directly from pharmacies or drugstores may be common when MSM experience symptoms of suspected sexually transmitted infections (STIs) related to se

Spatial Data Infrastructure (SDI) provides a platform for spatial data sharing and is a key for sustainable development. Developing countries, including Tanzania, are at different stages of implementing SDIs. The importance and advantage of implementation lie in the fact that considerable funds can be saved by avoiding duplication of data, and improving quality of decisions making as well as publi

Climate change has the potential to alter hydrological regimes and to expand saturated areas in permafrost environments, which are important sources of organic carbon. The sources, transfer zones, and delivery mechanisms of carbon into the stream network are controlled by the morphometric properties of the catchment; however, the utility and limitations of these properties as predictors of dissolv

Introduction: Health problems in people with intellectual and developmental disability (IDD) are traditionally known to be common in adults of all age, with at least twice as many health problems in this group as the general ageing population. In addition, there is considerable international evidence indicating an earlier death for people with IDD compared to the general population, exacerbated by

Ecosystem services are benefits supplied by ecosystem to human societies. In France, recent legislation aims to include ecosystem service in environmental impact studies with the enactment of the Law for the recovery of biodiversity, nature and landscapes (2016). To do so, it is necessary to develop field methods for ecosystem service estimation. In this setting, a collaboration was established be

This paper describes some research stimulated by a fundamental shift that is occurring in the manufacture and marketing of aero engines for commercial and defence purposes, away from the selling of products to the provision of services. The collaborating aerospace company offers contracts under which it remains responsible for the maintenance of engines which have been purchased by airlines throug

Turning sustainable is one of the largest challenges facing the aviation sector. Switching to sustainable aviation fuel (SAF) instead of fossil fuels is a large piece of the sustainability puzzle, but there is no current SAF that is approved as a stand alone fuel. The road to a stand alone SAF is long and requires more diverse biofuels as well as more research on how biofuels combust. This thesis