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Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal
Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by
Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin
This essay investigates the impact of classroom gender composition on the mental health of adolescent students. Using data from the Health Behaviours of School-aged Children survey in the Czech Republic, we exploit idiosyncratic classroom variation in the gender composition within the same schools across different grades. We find that a higher proportion of female peers in the classroom has a detr
Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on
AimTo assess the merit of clinical assessment tools in a neurocognitive screening following out-of-hospital cardiac arrest (OHCA).MethodsThe neurocognitive screening that was evaluated included the performance-based Montreal Cognitive Assessment (MoCA) and Symbol Digit Modalities Test (SDMT), the patient-reported Two Simple Questions (TSQ) and the observer-reported Informant Questionnaire on CogniAim: To assess the merit of clinical assessment tools in a neurocognitive screening following out-of-hospital cardiac arrest (OHCA).Methods: The neurocognitive screening that was evaluated included the performance-based Montreal Cognitive Assessment (MoCA) and Symbol Digit Modalities Test (SDMT), the patient-reported Two Simple Questions (TSQ) and the observer-reported Informant Questionnaire on C
Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas
Most developments in regenerative medicine have in common that there are many uncertainties and knowledge gaps. These features make the evaluation of long-term consequences of the available options difficult and have consequences for the ethical issues raised. This paper presents an overview of ethical issues raised in regenerative medicine, using as a starting point a list of stakeholders and the
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
Background: Ketogenic diet in children with epilepsy has a considerable impact on daily life and is usually adopted for at least 3 months. Our aim was to evaluate whether the introduction of an all-liquid ketogenic diet in an outpatient setting is feasible, and if an earlier assessment of its efficacy can be achieved.Methods: The authors conducted a prospective, observational study in a consecutiv
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar
Department of Arts and Cultural Sciences, Division of Ethnology Institutionen för kulturvetenskaper, Besöksadress LUX, hus C, Helgonagatan 3, Lund Webbadress www.kultur.lu.se COURSE LITERATURE Sida 1 av 2 2 Sida 3 av 2 Course literature for TKAN25: Introduction to Applied Cultural Analysis, 7,5 HP, Fall 2026 Established by the departmental board or equivalent, 2026-06-03. Literature is searched i
https://www.ht.lu.se/media/utbildning/dokument/kurser/TKAN25/20262/TKAN25_literature_list.docx - 2026-06-29
Department of Arts and Cultural Sciences, Division of Ethnology Institutionen för kulturvetenskaper, Besöksadress LUX, hus C, Helgonagatan 3, Lund Webbadress www.kultur.lu.se COURSE LITERATURE Sida 1 av 2 2 Sida 3 av 2 Course literature for TKAN25: Introduction to Applied Cultural Analysis, 7,5 HP, Fall 2026 Established by the departmental board or equivalent, 2026-06-03. Literature is searched i
https://www.kultur.lu.se/media/utbildning/dokument/kurser/TKAN25/20262/TKAN25_literature_list.docx - 2026-07-19
The thesis aims to explore what influences the Danish consumers when choosing food distribution channels in 2020 and further to test if current theories of consumers’ channel choice can be applied in the year of 2020. The thesis takes on a qualitative approach with mathematical principles and employs the Delphi Method as the primary method to collect data. To conduct the empirical analysis a desk
This essay compares the two Swedish municipalities Landskrona and Värnamo, in order to understand the difference in achieved integration on the labor market. By using Mill’s method of disagreement, and conducting interviews with persons with key positions in the integration process, based on theories of integration, the essay reaches the conclusion that authorities can be the difference between su
Scientific summary The increasing prevalence of natural disasters is driving people to pay more and more attention to emergency management. Progress in catastrophe analysis capabilities based on Geographical Information System (GIS) may allow the needs of public participation to be considered. Synchronous data sharing between citizens and emergency workers could effectively promote the process of
