Filtyp
Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to mature effector cells through a series of developmental steps. This is a tightly regulated, though a highly dynamic process: on the one hand, dysregulation in steady-state could lead to under- or overgrowth of certain blood cell lineages, whereas, on the other hand, demands for certain mature blood c
The aim of this Master's thesis is to discuss and analyse co-operation between public and academic libraries. The political changes that were initiated during 2004 have come to alter the conditions for Swedish libraries. The Swedish library law was changed at the 1st of January 2005 and co-operation between libraries is now statuary even if there is no description of how the new mission is to
As a school welfare officer you are often alone of having your perspective and must struggle to preserve that perspective. At the same time, there are very little defined what role a social worker should have in a school. This makes it nessesary to form and develop your role of profession independently. According to the Swedish school law, the schools are not required to employ a welfare officer.
Treaties are the most important source of international law, but treaties are only binding when in force, and only with respect to the nations that have expressly agreed to become parties to them. The Vienna Convention on the Law of Treaties, from 1969, is the ''treaty on treaties''. The rules on reservations in the Vienna Convention, articles 19 to 23, govern the situation where p
Thesis purpose: The purpose of the master thesis is to examine what affects Generation Y’s values, attitudes and beliefs towards the fair trade label and ecological quality labels. The purpose is also to investigate how these two quality labels are received by Generation Y, in order to delve deeper into the relationship between the labels. This research will contribute with new insights about Gene
Popular Abstract in Swedish Diabetes mellitus är en endokrin sjukdom. Hos friska individer producerar beta och alpha cellerna i bukspottkörteln insulin och glukagon, de viktigaste hormonerna för att reglera blodglukos¬koncentrationen. Insulin utsöndras som svar på förhöjda blodglukosnivåer. Hormonet minskar glukosproduktion från levern och ökar glukosupptaget samt dess användning och lagring i fetType 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. In addition to well-known hallmarks of the disease, such as defective insulin secretion, insulin resistance and perturbed glucagon secretion, we aimed to find a possible role for CLOCK genes in the pathogenesis of
Popular Abstract in Swedish Avhandlingen undersöker de två behandlingsalternativ, hemodialys och njurtransplantation, som är tillgängliga för personer med njursvikt. I fokus för undersökningen står de former av person- och patientskap som skapas och upprätthålls i hemodialys- och njurtransplantationsvården samt i de njursjukas vardagsliv. Ett av avhandlingens grundläggande antaganden är att dessa This thesis examines the practice of haemodialysis and kidney transplantation, the two medical therapies available for persons with kidney failure, from a phenomenological perspective. A basic assumption made in the thesis is that contemporary biomedicine is deeply embedded in the cultural, historical, economic, and political circumstances provided by the particular local, national, and transnatio
This thesis presents methods for improving the accuracy and efficiency of tasks performed using different kinds of industrial manipulators, with a focus on the application of machining. Industrial robots offer a flexible and cost-efficient alternative to machine tools for machining, but cannot achieve as high accuracy out of the box. This is mainly caused by non-ideal properties in the robot joint
Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. FLT3 mutations emerged as one of the most common mutations in AML which represent around 35% of all AML
Inflammatory airway diseases and lower respiratory tract infections are leading causes of severe illness, disability and death worldwide. Much of today´s hypotheses about the underlying inflammatory processes and pathogenic contribution by immune cells come from in vitro experiments or animal models. As a consequence, our knowledge of the actual immunopathological events in real patient tissues is
Intramolecular motions of proteins are critical for biological function. Transient structural fluctuations underlie a wide range of processes, including enzyme catalysis, ligand binding to buried sites, and generic protein motions, such as 180 degrees rotation of aromatic side chains in the protein interior, but remain poorly understood. Understanding the dynamics and molecular nature of concerted
Popular Abstract in Swedish Lokal läkemedelsstatistik – ett verktyg för att identifiera problemområden och att bedöma effekter av information och utbildning om läkemedel. Det finns behov att studera läkemedelsförskrivning och läkemedelsanvändning och dessas samband med och effekter på hälsa, sjuklighet och överdödlighet. Det är också önskvärt att kunna använda individdata. I Sverige är det i allmAims: 1) To assess if drug sales data indicate differences in morbidity, mortality, socio-economic conditions and deviating prescribing habits among physicians; 2) to identify areas for educational interventions and to analyse changes in prescribing after educational activities. In addition, an effort was made to estimate differences between pharmacy sales and purchases by the population, and the
Brämhults Juice AB is a Swedish company producing fresh juice for the Scandinavian market. Fresh juice is rich in taste but has limited durability and must be treated with special care throughout the whole supply chain. Not only will the quality of the product be affected if mistreated, but there are also contamination risks meaning that people actually could get sick, although the risk is very sm
Surface display in insect cells: Systems available for surface display that utilize bacterial phages are insufficient for displaying a number of eukaryotic proteins. By instead presenting proteins on the surface of eukaryotic cells or virus, some of these problems might be overcome. The baculovirus/insect cell system, which has a high expression rate and post-translational mashinery closely resemb
The design and analysis of specular radar absorbing materials are investigated throughout the dissertation. Although the topic has been investigated for more than 60 years by many researchers and numerous designs have been proposed, still many technical challenges are remained unanswered. The basic questions are, e.g., the optimal thickness of a design, the possibility of utilization of unconventi
The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. This leads to loss of control of blood glucose lev
Abstract Due to developments in the last decades in the field of protein production, new technologies for bio-separation have evolved. Especially in the field of affinity chromatography, the search for new ligands is of great interest. Besides the antibodies used as affinity ligands, synthetic ligands were introduced. Textile dyes were a first group to be introduced but despite their selectivity a
Despite the ongoing globalisation of economic activities, innovation does not take place randomly distributed over space, but concentrates in certain locations. A central argument to explain the spatial concentration of innovation activities lies in the ability of geographical proximity to facilitate interactive learning and knowledge exchange, which in turn is seen as an important driver for regi
Popular Abstract in Swedish En av de stora vetenskapliga bedrifterna hittills under 2000-talet är onekligen att man efter många års arbete för första gången lyckades kartlägga (sekvensera) samtliga mänskliga gener. Det mänskliga DNA:t är lokaliserat till cellkärnan och i princip så kan man likna en cellkärna med ett kontrollrum fyllt av manualer (DNA) som talar om cellens sammansättning och hur deProteomics is expected to generate new insights into biological processes as well as identify novel biomarkers and therapeutic targets since most biological functions are transmitted through proteins. However, due to the complexity displayed by a proteome and inherent limitations associated with current methodologies, proteomic analyses often result in incomplete coverage and inconsistent measurem
Popular Abstract in Swedish Avhandlingen handlar om den aspekt av människans självbild, eller självet, som på engelska kallas possible selves, och som på svenska skulle kunna kallas "möjliga själv" (en etablerad svensk översättning saknas). Detta är framtidsföreställningar eller framtidsbilder där vi ser oss själva i framtida situationer eller tillstånd, och teorin om möjliga själv presenterades fPossible selves are conceptions or images of ourselves in future states or situations. The theory about possible selves used in the present thesis was developed in a social cognitive tradition of research on the self, where the self is seen as a knowledge structure (Markus & Nurius, 1986). Possible selves are parts of this knowledge structure and possible selves are of importance for motivatio
