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ABSTRACT The aim of the present work was to compare patients with advanced cancer receiving specialized palliative home care with those receiving conventional care. A hospital-based advanced home care programme was initiated, in order to enable patients to remain at home for a longer period and to choose to die at home. The allocation to advanced home care (AHC) or conventional care (CC) was perf
Readouts that define the physiological distributions of drugs in tissues are an unmet challenge and at best imprecise, but are needed in order to understand both the pharmacokinetic and pharmacodynamic properties associated with efficacy. Here we demonstrate that it is feasible to follow the in vivo transport of unlabeled drugs within specific organ and tissue compartments on a platform that appli
High-energy proton- and deuteron-nucleus collisions provide an excellent tool for studying a wide array of physics effects, including modifications of parton distribution functions in nuclei, gluon saturation, and color neutralization and hadronization in a nuclear environment, among others. All of these effects are expected to have a significant dependence on the size of the nuclear target and th
Popular Abstract in Swedish Skulle p53-målgenen TRIM22 kunna skydda mot cancer uppkomst? Frisk blodbildning En frisk vuxen människa har mellan fyra och sex liter blod, beroende på individens kroppsstorlek. Blodet produceras i benmärgen som finns i skelettbenen. Varje sekund bildas normalt i benmärgen tre till fyra miljoner blodkroppar från våra stamceller. Blodkropparna är specialiserade celler The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. Using a cDNA microarray analysis, I identified TRIM22/Staf50 as a novel direct target gene to p53. The fun
The conceptual shift in the expectations of the wireless users from voice towards multimedia, from availability towards acceptable quality, and from stand-alone towards group-oriented computing has a significant impact on today's networks in terms of the need for mobility, quality of service (QoS) and multicasting. Ad hoc networks, being independent of any fixed infrastructure, can provide mobile
Background: The European Molecular Genetics Quality Network (EMQN) was formed in order to improve external quality assessment for molecular genetic testing in Europe. From 1999 to 2002 it received funding from the European Union under the Standards, Measurement and Testing programme (contract no. SMT4-CT98-7515). Since then, its maintenance has been supported through subscription of the participan
An extensive research program, dealing with fire growth on combustible wall lining materials, has been ongoing in Sweden over the last decade. Several lining materials were tested in bench-scale fire tests in order to derive basic material flammability parameters. The same materials were also tested in a full scale room test and a 1/3 scale room test for two different scenarios, A and B. Scenario
Elder law is often approached in terms of a 'body' of law. In this article, I argue for a contextualised and externalised perspective on the ageing individual as the subject of elder law. Elder law relates to the implications of law as an institutionalisation of society seen through the lens of older persons. The aged subject is a contested and differentiated social construct to be studied in rela
Background: The efficacy of cervical cancer screening programs is dependent on the participation rate. To increase participation among women not attending cervical cancer screening, self-collected samples for detection of high-risk human papillomavirus (hr-HPV) may be an option. The aims of this study were: to investigate the response rate to sending a self-collected vaginal sample for hr-HPV mRNA
According to the waste hierarchy principle, which constitutes the basis of European waste legislation, waste prevention and re-use are considered – most of the times – better waste management options than recycling. However, prevention and re-use activities are difficult to operationalise and measure, without a monitoring framework in place. This contribution investigates the potential of re-using
Ocean Drilling Program (ODP) Site 1051 (Blake Nose, western North Atlantic) is of crucial importance for reconstructing diatom evolution and biosiliceous sedimentation patterns through the early Cenozoic period of extreme greenhouse warmth followed by the progressive global cooling. The magnetostratigraphy in Hole 1051A, however, has been subject to divergent interpretations resulting in multi-mil
Background: Limiting tidal volume (VT), plateau pressure, and driving pressure is essential during the acute respiratory distress syndrome (ARDS), but may be challenging when brain injury coexists due to the risk of hypercapnia. Because lowering dead space enhances CO2 clearance, we conducted a study to determine whether and to what extent replacing heat and moisture exchangers (HME) with heated h
Hypothesis: Nitric oxide (NO)-releasing Pluronic F127 hydrogels (F127) containing dissolved S-nitrosothiols or pendant N-diazeniumdiolate (NONOate) groups have been described. The NO charging of these hydrogels is usually limited by their low stability or disruption of the micellar packing. S-nitrosothiol-terminated F127 may emerge as a new strategy for allowing NO delivery at different rates in b
Among the layers of a plant community, the canopy has the most important hydrological function in water circulation. Understanding the canopy’s inner structure and its relationship to water transport is fundamental for the functional mechanisms of the vegetation canopy. Using an artificial rainfall simulator to supply three levels of rainfall intensity, the interception of rainfall by the canopy w
Among the layers of a plant community, the canopy has the most important hydrological function in water circulation. Understanding the canopy’s inner structure and its relationship to water transport is fundamental for the functional mechanisms of the vegetation canopy. Using an artificial rainfall simulator to supply three levels of rainfall intensity, the interception of rainfall by the canopy w
Purpose-The purpose of this paper is to address the issue of supply management coordination among a prominent contact lens company (customer), its carton supplier (first tier), and paperboard supplier (second tier). Adopting concepts within the theory of swift and even flow, the authors integrate the physical (material) and information flow among these supply partners to ensure higher productivity
This work focuses on the optimization of the Nuclear Reaction Analysis (NRA) technique to determine the content of lithium and fluorine in geological materials. Measuring low concentration of these isotopes is of great relevance in many fields such as geological, astrophysical, biological and material sciences. Light elements as lithium and fluorine are considered as geochemical tracers in vario
This presentation gives an overview of a peer learning model and academic support intervention named SI-PASS (Supplemental Instruction – Peer Assisted Study Schemes) in Higher Education in Europe. SI-PASS is a method of improving student performance in “difficult”, normally introductory, courses combining “how to learn” with “what to learn”. SI-PASS sessions are scheduled parallel to the regular e
