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Purpose: Radiomics entails the extraction of quantitative imaging biomarkers (or radiomics features) hypothesized to provide additional pathophysiological and/or clinical information compared to qualitative visual observation and interpretation. This retrospective study explores the variability of radiomics features extracted from images acquired with the 0.35 T scanner of an integrated MRI-Linac.

The human lung is a complex tissue consisting of a heterogeneous mix of different structures and cells, each which a specific role that together contribute to the primary function of the organ: the gas exchange. Different mesenchymal cells populate the interstitial areas around airways and blood vessels and form the connective tissue together with the extracellular matrix. Fibroblasts constitute o

PURPOSE: Oxaliplatin is increasingly becoming the chemotherapeutic drug of choice for the treatment of peritoneal malignancies using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Oxaliplatin is unstable in chloride-containing media, resulting in the use of 5% dextrose as the carrier solution in these procedures. Exposure of the peritoneum to 5% dextrose during pe

Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (

Context. X-ray extragalactic surveys are ideal laboratories for the study of the evolution and clustering of active galactic nuclei (AGN). Usually, a combination of deep and wide surveys is necessary to create a complete picture of the population. Deep X-ray surveys provide the faint population at high redshift, while wide surveys provide the rare bright sources. Nevertheless, very wide area surve

Importance: Patients with amnestic mild cognitive impairment (aMCI) may progress to clinical Alzheimer disease (AD), remain stable, or revert to normal. Earlier progression to AD among patients who were β-amyloid positive vs those who were β-amyloid negative has been previously observed. Current research now accepts that a combination of biomarkers could provide greater refinement in the assessmen

An algorithm specific digital signal processor is a powerful alternative to a general purpose signal processor for demanding specifications such as high throughput, low power, small size, etc. These properties are achieved as the processor architecture is tailored to the algorithm as opposed to the general purpose architecture which must suit a wide range of algorithms. The increased performance i

OBJECTIVE: To cross-validate, prospectively, the diagnostic performance of established ultrasound methods for discrimination of benign and malignant pelvic masses. METHODS: A total of 173 consecutive women with a pelvic mass judged clinically to be of adnexal origin underwent preoperative ultrasound examination including color and spectral Doppler techniques. A total of 149 tumors were benign, and

Background: Clearance of tissue granulocytes is central to the resolution of airway inflammation. To date the focus has been on apoptotic mechanisms of cell removal and little attention has been given to alternative processes. The present study explores transepithelial migration as a mechanism of cell clearance. Method: Guinea pig tracheobronchial airways where eosinophils are constitutively pres

Popular Abstract in Swedish Tarmsjukdomen celiaki, glutenintolerans, är en av våra vanligaste kroniska sjukdomar som utvecklas då man inte tål ämnet gluten, ett protein som framför allt finns i vete, råg och korn. För att utveckla celiaki krävs en genetisk sårbarhet, vilket innebär att man i arvsmassan bär på en benägenhet som gör att man kan utveckla sjukdomen vid intag av mat innehållande glutenAbstract Sweden experienced an epidemic (1984-96) of celiac disease in children, partly attributed to changes in infant feed- ing. Our aim was to compare the total prevalence of celiac disease in two birth cohorts of 12-year-olds and relate the findings to each cohort’s ascertained infant feeding. Furthermore, we compared the growth parameters in the children with screening-detected celiac disease

With the advent of multimodality therapy, the overall five-year survival rate from childhood cancer has improved considerably now exceeding 80% in developed European countries. This growing cohort of survivors, with many years of life ahead of them, has raised the necessity for knowledge concerning the risks of adverse long-term sequelae of the life-saving treatments in order to provide optimal sc

Background: Thrombolysis is a common method in the treatment of lower extremity bypass graft occlusion. The purpose of this study was to investigate the results of thrombolytic therapy in the management of acute bypass graft occlusion and to identify risk factors for technical failure and amputation. Methods: All patients at two tertiary referral centers undergoing thrombolysis for acute graft occ

This study explores the meaning of the two expressions 'times of refreshing' and 'time to restore everything' in Acts 3:19.21. These two eschatological motifs appear in a speech that the apostle Peter made, according to Luke's presentation, in the Jerusalem temple in the beginning of the 30s. The study is historical, and the meaning of the two expressions is sought in the contemporary world. It i

Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) are assoc

The analysis of general charge sampling technique is presented in this thesis. Charge sampling integrates input current instead of tracking input voltage to realize high speed and low voltage sampling. The analysis focuses on the performance of general charge sampling circuits for signal capture. The theoretical analysis here can be applied not only for the weak signal capture, but also for the no

Background and objective: Human studies of arterio-venous (AV) differences in drug concentrations and the consequences for pharmacokinetic modelling and concentration-effect relationships are very limited. We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men.

Popular Abstract in Swedish Denna avhandling handlar om utveckling och tillämpning av metoder för jonstråleanalys av lätta ämnen (lättare än ungefär aluminium), framförallt vid en nukleär mikrosond. Vid en nukleär mikrosond accelereras tunga partiklar, t.ex. protoner, av en partikelaccelerator och fokuseras av ett speciellt magnetiskt linssystem ned till en storlek av ungefär 1 mikrometer. Denna sThis thesis treats the development of Ion Beam Analysis (IBA) methods, principally for the analysis of light elements at a nuclear microprobe (NMP). The light elements are in this context defined as those with an atomic number Z of less than approximately 13 (aluminium). The work reported is to a large extent based upon multiparameter methods. Several signals are acquired simultaneously, and the d

Popular Abstract in Swedish Denna avhandling rapporterar om karakterisering och tillmpningar av extrem ultraviolett (XUV) strålning som genererats av övertonsgenerering samt i en frielektronlaser. Övertonsgenerering är en process som uppstår när en kraftfull kortvarig laserpuls fokuseras i ett gasmedium. De laserpulser som används är bara några femtosekunder (10−15s) långa och har en våglängd i This thesis reports experimental studies performed with two advanced coherent XUV sources with ultrashort pulse duration, high-order harmonic generation and seeded-free electron laser. High-order harmonic generation (HHG) is the generation of overtones of a fundamental laser pulse in a medium, e.g. noble gases. The emitted radiation has a high degree of transverse coherence, and pulse lengths in t