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The thesis is focused on an attempt to delay photoreceptor cell death in the rd1 mouse using Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model displays a reti

Due to the increasing interest of producing power from renewable and non-conventional resources, organic Rankine cycles are finding their place in today’s thermal energy mix. The main influencers on the efficiency of an organic Rankine cycle are the working fluid and the expander. Therefore most of the research done up to date turns around the selection of the best performance working media and th

Popular Abstract in Swedish Den globala energianvändningen är idag större än någonsin. Faktum är att den, i takt med världens ständiga utveckling, kommer att fortsätta öka många år framöver. Sättet som energi har producerats på historiskt används dessutom i allra högsta grad fortfarande idag och innebär daglig förbränning av stora mängder organiskt material. Detta resulterar i en ökad koncentratioThis dissertation covers studies of excited state processes in two types of solar energy materials: alternating polyfluorene polymers and their blends with fullerenes in the active layer of plastic solar cells, and bis-tridentate RuII-polypyridyl complexes to be used as sensitizer in systems for artificial photosynthesis. The polymer:fullerene blends were studied by transient absorption and time-

In his book Visual thinking, Arnheim (1969) writes: ... cognitive operations called thinking are not the privilege of mental processes above and beyond perception but the essential ingredients of perception itself. I am referring to such operations as active exploration, selection, grasping of essentials, simplification, abstraction, analysis and synthesis, completion, correction, comparison, prob

Abstract: Purpose – While the importance of measuring customer satisfaction levels is well established, less research exists on how organizations operationalize such knowledge. The purpose of this paper is to describe an action research (AR) case study resulting in a workshop model to operationalize the concept of value. The model facilitates organizational learning and mindset changes in order to

Background: Glial cell line-derived neurotrophic factor (GDNF) is the most promising neurotrophin for restorative treatments in Parkinson's disease, but its biological effects are not completely understood. Objective: To define a model of GDNF gene therapy in the mouse, we studied the long-term effects of lentiviral GDNF delivery in mice with striatal 6-hydroxydopamine (6-OHDA) lesions. Methods: L

Time-resolved small-angle neutron scattering (TR-SANS) was employed to observe temperature-induced phase transitions from the sponge (L-3 to the lamellar ( L (alpha) phase, and vice versa, in the water-oil (n-decane)-non-ionic surfactant (C12E5 system using both bulk and film contrast. Samples of different bilayer volume fractions phi and solvent viscosities eta were investigated applying various

The question asked in this thesis is: what is the impact on the democratic legitimacy of the legal orders of the member states of the EU, where the meaning of EU fundamental rights is determined by the Court of Justice of the EU. It begins by developing a theoretical framework which reconstructs the deep structure of the law of the member states, in order to understand the ground of legitimacy for

Pancreatic islet hormone secretion is central in the maintenance of blood glucose homeostasis. During development of hyperglycaemia, the β-cell is under pressure to release more insulin to compensate for increased insulin resistance. Failure of the β-cells to secrete enough insulin results in type 2 diabetes (T2D). MicroRNAs (miRNAs) are short non-coding RNA molecules suitable for rapid regulation

ERP systems became popular with large organizations in the 1990s. In the 21st Century, these products were expanded by addition of supply chain management (SCM) and customer relationship management (CRM), as well as access through the Web, creating the ERP II concept. Efforts to increase the market led vendors to serve not only large organizations, but also focus more on small-to-medium sized ente

Today, the innovation arena is open to a wider range of participants than previously acknowledged. One specifically neglected group of innovators in traditional innovation studies is non-R&D and non-managerial employees, also referred to as ‘ordinary’ employees by the existing body of literature on employee-driven innovation (EDI). These employees have no formal innovation function, meaning th

questions: Where are the largest gaps between how HES (Heat Exchanger System) are working today and how they could be working according to lean philosophies? How could these gaps be reduced and what effect will it have to HES and their customers? Deliverables: The project contains a gap analysis which is the foundation to a new suggested work pattern. The new work pattern was implemented, evaluate

We obtained a long-time-storage mechanism for spectral features in thulium ions doped into YAG by applying a magnetic field that splits the electronic ground state. We show experimentally that the storage time can be more than 30 s, which is 3 orders of magnitude longer than that of the metastable state that normally is used for information storage in this material. Level splitting and storage lif

This thesis is conducted in collaboration with Alfa Laval Lund AB. Alfa Laval is a world leading producer of heat transfer, separation and fluid handling equipment. The products help Alfa Laval’s customers to heat, cool, separate and transfer products such as oil, water, chemicals, beverages, starch and pharmaceuticals in over 100 countries all over the world. The hardening competition together wi

Diabetic wounds are problematic to heal owing to microbial infections as well as decreased proliferation and high concentrations of reactive oxygen species. In this study, a double-layered nanofibrous mat containing grape seed extract (GSE) and silver sulfadiazine (SSD) was fabricated. A synthetic biodegradable polymer, e.g., polycaprolactone (PCL), and a natural material (i.e., collagen) were emp

The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi