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Several processes in the cell, such as gene regulation, start when key proteins recognize and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple diffusion: diffusion-limited association rates may underestimate in vitro measurements up to several orders of magnitude. Moreover, the rates increase if the D
We present the first large-scale study that demonstrates how ages can be determined for large samples of stars through Galactic chemical evolution. Previous studies found that the elemental abundances of a star correlate directly with its age and metallicity. Using this knowledge, we derive ages for 214 577 stars in GALAH DR3 using only overall metallicities and chemical abundances. Stellar ages a
Square Kilometer Array (SKA) is a project aimed to build the largest radio telescope in the world and it has just gotten into the construction phase. In this phase, the ability to develop and integrate software in an integration environment is crucial as it is the ability to visualize system-related information via a User Interface to rapidly verify the correctness of the system behavior and spot
Sodium niobate (NaNbO3 or NN) is described as "the most complex perovskite system,"which exhibits transitions between, as well as coexistence of, several ferroelectrics (FE) and antiferroelectric (AFE) phases at different temperatures. Recently, solid solutions of NN with stabilized AFE phases(s) have gained attention for energy-related applications, such as high-density energy storage and electro
This article argues that George Eliot's The Mill on the Floss (1860) aligns natural catastrophe with the image of the disastrous female body in order to challenge contemporary geological readings of nature as a balanced, self-regulating domain. Both incorporating and revising the work of Charles Lyell, Oliver Goldsmith, and Georges Cuvier, Eliot emphasises the interconnectedness of human and plane
The objective of this study was to develop a population pharmacokinetic–pharmacodynamic model of subcutaneously administered bupivacaine in a novel extended-release microparticle formulation for postoperative pain management. Bupivacaine was administered subcutaneously in the lower leg to 28 healthy male subjects in doses from 150 to 600 mg in a phase 1 randomized, placebo-controlled, double-blind
The vertical positioning of benthic invertebrates should be a trade-off between the risky, but productive, sediment surface and the safer, but physiologically harsher, conditions deeper down in the sediment. This is because the foraging efficiency of benthic fish decreases with sediment depth, whereas the sediment surface is generally better oxygenated and has a higher resource quality than lower
Aims of this thesis were to compare the agreement of different magnetic resonance angiography(MRA) techniques and digital subtraction angiography (DSA) in follow-up of intracranial aneurysms treated with coils in order to select the best MRA method, to evaluate the impact of increased iodine concentration in contrast medium and decreased tube voltage on arterial attenuation and image quality in co
Pulsatile flows in geometries of physiological relevance have been investigated. Atherosclerotic plaques are (initiated) near junctions and bifurcations in larger arteries. The flow in these regions is characterized by flow separation and unsteadiness, which indicates that local flow conditions contribute to atherogenesis. Flows in curved and bifurcating pipes have been investigated over many y
Carbohydrate-deficient transferrin (CDT) is a generic term that refers to the transferrin glycoforms whose concentration in blood is temporarily increased by sustained alcohol consumption. Due to high clinical specificity, CDT was proposed as a biomarker of heavy alcohol use and has been available for about 20 years. A number of methods have been developed for CDT measurement based on different an
Athletes constantly report experiences of momentum during athletic contests, and they consider momentum as being an important factor for the outcome of a competition. However, researchers trying to capture momentum with quantitative methods see themselves confronted with inconclusive results. To explain this gap between athletes’ belief and results from quantitative data, it is hypothesised that m
Spatial data are crucial in disaster planning. However, because of the dynamic, urgent and uncertain nature of disasters, certain data and functionalities may be inaccessible to decision makers when they are required. Web service composition offers a possible solution whereby disaster planners can integrate spatial web services to generate new spatial data and functionalities, quickly, from existi
The aim of the present Study was to make a 16-year follow-up of children of psychosocial risk mothers as concerns emotional/behavioural problems, self-esteem, life events, and academic grades. Forty-three teenagers (index group) and 61 reference teenagers were personally interviewed and asked to answer the Youth Self-report (YSR), the Self-image questionnaire I Think I Am, and a Life Event questio
This thesis concerns paragraph 30, 31 and 32 of the Consumer Insurance Act. The Consumer Insurane Act was adopted in 1981. It is applicable to combined insurance policies covering fire, burglery, liability, and certain other risks when the insured party is a consumer. In these cases, the Consumer Insurance Act is applicable to motor vehicle-, yachting- and travelling insurance contracts as well.
The hydrophilic/hydrophobic properties of the membrane material have an important influence on the membrane flux reduction when treating solutions containing hydrophobic solutes. Different methods of measuring the hydrophobic properties of membranes have been evaluated; measurement of the contact angle being the most commonly used method. In this investigation the flux reduction of eight membranes
There is compelling evidence to suggest that estrogen administration to women of climacteric age reduces subsequent myocardial infarction by some 50%. Accumulating data also suggests estrogens confer substantial protection from stroke. Given this rationale, it is prudent to suggest to regulatory bodies that estrogen treatment would have this indication. Estrogens have other well-defined, and less
Understanding farmer behaviour is needed for local agricultural systems to produce food sustainably while facing multiple pressures. We synthesize existing literature to identify three fundamental questions that correspond to three distinct areas of knowledge necessary to understand farmer behaviour: 1) decision-making model; 2) cross-scale and cross-level pressures; and 3) temporal dynamics. We u
Dumping is generally considered an unfair practice and through the Antidumping Agreement of the GATT many governments offer protection to domestic producers against dumped goods. In 1992 and 1998 large amounts of steel entered the U.S. at low prices, and large amounts of antidumping investigations were initiated in order to curb the surge of imports flooding the country. The increase in steel imp
