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How coordination of metal ions modulates protein structures is not only important for elucidating biological function but has also emerged as a key determinant in protein turnover and protein-misfolding diseases. In this study, we show that the coordination of Zn2+ to the ALS-associated enzyme Cu/Zn superoxide dismutase (SOD1) is directly controlled by the protein's folding pathway. Zn2+ first cat

III-V semiconductors have attractive transport properties suitable for low-power, high-speed complementary metal oxide-semiconductor (CMOS) implementation, but major challenges related to cointegration of III-V n- and p-type metal-oxide-semiconductor field-effect transistors (MOSFETs) on low-cost Si substrates have so far hindered their use for large scale logic circuits. By using a novel approach

Traditionally, heavy-duty diesel engines have high efficiencies but also high emissions of NOx and soot particles. New engine concepts show the potential to retain diesel-like efficiencies while reducing emissions by forming a completely or partially homogeneous mixture of fuel and air prior to ignition through compression. The long ignition delay required to form this homogeneous mixture makes th

In this article we present a spatio-temporal dynamic model that can be realized using image warping. Image warping is a non-linear deformation which maps every point in one image plane to a point in another image plane. Using thin-plate splines, these deformations are defined by how a small set of points is mapped, making the method computationally tractable. In our case the dynamics of the proces

In the framework of the multiconfiguration Dirac-Hartree-Fock method, we investigate the transition properties of four excited states in the 2p(5)3s configuration of neutral neon. The electron correlation effects are taken into account systematically by using the active space approach. The effect of higher-order correlation on fine structures is shown. We also study the influence of the Breit inte

Doping mechanisms of Mn in GaAs nanowires (NWs) that have been grown self-catalytically at 600 degrees C by molecular beam epitaxy (MBE) are investigated using advanced electron microscopy techniques and atom probe tomography, Mn is found to be incorporated primarily in the form of non-magnetic tetragonal Ga0.82Mn0.18 nanocrystals in Ga catalyst droplets at the ends of the NWs, while trace amounts

The inherent limitations of a specific pencil beam model have been studied when applied to a cylindrical geometry simulating the neck region. A comparison is made between measured and calculated absorbed dose in a cylindrical phantom. The goal is to quantify the deviations in the absorbed dose level, i.e., the dose per monitor unit, when photons are used for the treatment of head and neck tumours.

International Relations (IR) research is constantly undergoing change, both in reaction to real changes in international politics and to new patterns of and trends in cooperation and conflict, as well as to methodological innovations within the academy. In general the discipline of IR has paid extensive attention to the definition and dynamics of conflict, while in comparison fewer efforts have be

Fractionation of kraft black liquor by ultrafiltration is receiving a great deal of interest at the moment, mainly because the extracted lignin can be used as a biofuel, but also because there are indications that the pulp quality is improved when permeate is used instead of black liquor as the diluent in the cooking process. Fractionation of kraft black liquor calls for membranes that can withsta

*Summary: The bacterium Escherichia coli is a common host organism for recombinant protein production. A problem encountered is the accumulation of the by-product acetate, which tends to reduce growth and protein production (1). Formation of acetate can be avoided by a proper substrate feeding strategy, but most strategies require considerable process knowledge to work well. The main problem is th

As an alternative to traditional top-down techniques for fabrication of one-dimensional devices we here report an approach wherein a bottom-up technique is used to create one-dimensional device structures. We use the vapor-liquid-solid growth method, in which a catalytically active gold nanoparticle forms a eutectic alloy with the nanowire constituents. Our method of growth allows atomically abrup

Pekskärmar är en typ av inmatningsenhet som möjliggör en interaktion mellan en användare och en elektronisk enhet. Interaktionen sker genom att låta användaren röra med en eller flera fingrar eller en stylus-penna på skärmen. Pekskärmar används idag till en rad olika elektroniska produkter som till exempel mobiltelefoner, surfplattor, datorer och även bankomater. På grund av sitt breda användningsTouchscreens are a type of input device that facilitate interaction between a user and an electronic device. This interaction is enabled by the user touching the screen with one or more fingers or a stylus pen. Today, touchscreens are implemented in a wide range of electronic products for example mobile phones, tablets, computers, and even ATMs. Due to their wide range of applications, touchscreen

The objective of this project was to design a casual dinner chair for smaller cafes and restaurants that prioritize locally produced ingredients and want to reflect that in their interior design. The aim was to use locally sourced materials from southern Sweden, integrate design and construction to simplify the manufacturing process, and reduce material waste. Additionally, the distribution of the

Att en tappande säljare på grund av res judicata hindras att yrka betalning för samma vara i ett senare mål är uppenbart, men för en köpare kan det komma som en överraskning att hon därmed beskurits möjligheten att tala å fel i det sålda godset. Enligt principen om betalningsskyldighetens odelbarhet anses betalningsskyldigheten för en vara eller tjänst odelbar i rättskraftshänseende. HD uttrycker Owing to the principle of res iudicata, it is obvious that a seller of goods who have found himself on the losing side of a court case may not again pursue further litigation against the defendant. For the defendant however, it may come as a surprise that she is thus cut off from the opportunity to initiate a lawsuit against the seller on the grounds of the goods being faulty. According to the pri

Background: The literature reviewed in the context of this master’ programme frequently refers to the enormous and increasing flows of people in the global era (Dicken, 2007; Lechner, 2004; Yeates, 2008); consequently, these flows have different directions and motives and represent diverse types of migration and migrants. As a result, the pivotal point here is the specificity of scientific migrati

Purpose: To assess implementation of an electronic patient reported outcomes platform, Recovery Tracker, which characterizes short term recovery following radical orchiectomy in patients with testicular cancer. Methods: Recovery Tracker was assigned based on procedure codes to patients undergoing radical orchiectomy at our institution. Patients were surveyed daily for the 10-day postoperative peri

Nuvarande reglering av säkerhet i lös egendom i Sverige bygger, med undantag för några lagstiftningsåtgärder, på rättspraxis och juridisk doktrin. Även om pantsättning är huvudmetoden för att ställa säkerhet, används i praktiken flera olika typer av säkerhetsrätter då lagstiftaren infört separata registersystem (t.ex. företagshypotek) och då äganderätt i praktiken ofta används som säkerhet (t.ex. Present Swedish law concerning security over movable assets is largely based on case law and legal literature, with some statutory intervention. Although the principal form of security is the possessory pledge, various security devices are used in practice, pursuant to legislative introductions of separate registration systems (e.g. floating charges) and the commercial use of ownership for securit

Sequencing of immunoglobulin germline gene loci is a challenging process, e.g. due to their repetitiveness and complexity, hence limiting the insight in the germline gene repertoire of humans and other species. Through next generation sequencing technology, it is possible to generate immunoglobulin transcript data sets large enough to computationally infer the germline genes from which the transcr