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Objective: Patients with degenerative or traumatic meniscal tears are at high risk of developing knee osteoarthritis. We investigated if younger (≤40 years) and older (>40 years) patients with preoperative mechanical symptoms (MS) improved more in patient-reported outcomes after meniscal surgery than those without MS. Design: Patients from Knee Arthroscopy Cohort Southern Denmark (KACS) undergoing
Autologous blood or marrow transplantation (BMT) is a curative option for several types of childhood cancer. However, there is little information regarding the risk of late mortality. We examined all-cause mortality, relapse-related mortality (RRM), and nonrelapse-related mortality (NRM) in 2-year survivors of autologous BMT performed before age 22 between 1980 and 2010 at 1 of 2 US transplant cen
Head turning experiments are widely used to test the cognition of both human infants and non-human animal species. Monitoring head turns allows researchers to non-invasively assess attention to acoustic or visual stimuli. In the majority of head turning experiments, the head direction analyses have been accomplished manually, which is extremely labor intensive and can be affected by subjectivity o
Context: Pulmonary arterial hypertension (PAH) affects people of all ages and is associated with poor prognosis. Chronic breathlessness affects almost all people with PAH. Objectives: This randomized, placebo-controlled, double-blind, crossover study aimed to evaluate the effects of regular, low-dose, extended-release (ER) morphine for PAH-associated chronic breathlessness. Methods: Participants w
OBJECTIVES: Statins may decrease the risk of primary venous thromboembolism (VTE), that is, deep vein thrombosis (DVT) and pulmonary embolism (PE) but the effect of statins in preventing recurrent VTE is less clear. The aim of this study was therefore to investigate the association between statin therapy and risk of recurrent VTE.DESIGN: A prospective cohort study.SETTING: All hospitals in Denmark
This work reports on numerical investigation of effects of ambient pressure (Pam) on spray combustion under engine-like conditions. Three cases with different Pam of 42, 85 and 170 bar at a fixed ambient temperature of 1000 K are considered. Zero-dimensional calculations are first performed for autoignition of stagnant adiabatic homogenous mixtures to evaluate performance of the selected diesel su
Objectives: Endometriosis has been associated with a wide range of factors. The disease share immunological features with autoimmune diseases, and the prevalence of both hypo- and hyperthyroidism has been reported to be increased. However, the associations have to be confirmed and the mechanisms explored. The aim of this observational study was to investigate socioeconomic factors, lifestyle habit
The costs and consequences of donepezil versus placebo treatment in patients with mild to moderate Alzheimer's disease (AD) were evaluated as part of a 1-year prospective, double-blind, randomized, multinational clinical trial. Patients received either donepezil (n = 142; 5 mg/day for 28 days followed by 10 mg/day according to the clinician's judgement) or placebo (n = 144). Unit costs were assess
Context: Epigenetics may contribute to sex-specific differences in human liver metabolism. Objective: To study the impact of sex on DNA methylation and gene expression in human liver. Design/Setting: Cross-sectional, Kuopio Obesity Surgery Study. Participants/Intervention: We analyzed DNA methylation with the Infinium HumanMethylation450 BeadChip in liver of an obese population (34 males, 61 femal
Objectives: This study examines the prevalence of pregnancy in serodiscordant couples and identifies predictors associated with pregnancy in rural Rakai, Uganda. Study design A population-based cross-sectional study that used data from the Rakai Community Cohort Study (RCCS). Setting and participants: We used data from the RCCS survey round 17 (2015-2016), which included 488 women in serodiscordan
Populärvetenskaplig sammanfattning: Havsnivåförändringar på södra Grönland. Den globala havsnivån har förändrats under den nuvarande mellanistiden främst på grund av fördelningen av vatten mellan hav och glaciärer. Den relativa havsnivån på södra Grönland påverkas också till stor del av jordskorpans anpassning till storleken på det grönländska istäcket. I denna studie presenteras en ny strandförUntil recently there have only been a few observations of relative sea-level change from the inner Bredefjord area in southern Greenland. Here a new sea-level curve is presented from the Tasiusaq area based on data mainly from a sediment sequence from a marine embayment. Sea-level changes can be recorded in sediments as changed chemical composition, physical properties and macrofossil content. Iso
The effect from mechanical-biological pre-treatment (MBT) of wastes in Sweden and Germany has been studied. The organic matter and biological activities were studied and compared. Other parameters such as heavy metals and nutrients were examined and related to the organic matter. The effect of low water content on degradation was investigated and the relevant legislation in the two countries was s
This essay focuses on the increasing problems for companies and right-holders with counterfeited and pirated goods in the European Union and the problems for right holders to enforce their IPR rights. Will IPRED1 make a difference and is there really a need for the new Directive of Enforcement 2004/48/EG, or do the sanctions according to the TRIPS Agreement suffice. Further, IPRED2 is a follow up
Breath-hold ECG-gated cardiovascular magnetic resonance (CMR) imaging is challenging during exercise due to motion, ECG-problems, and lengthy scans. To facilitate time-resolved volumetric measures from exercise-CMR, we aimed to develop a method for constructing time-resolved ventricular cines from real-time free-breathing exercise-CMR. Time-resolved ventricular cines were semi-automatically constr
Background: A Swedish version of the Patient-Rated Ulnar Nerve Evaluation (PRUNE-S), a patient-reported outcome measure for ulnar nerve entrapment, was created, according to cross-cultural adaptation guidelines, and reliability, validity, and responsiveness were evaluated. Methods: In total, 43 patients (mean [SD] age, 49 [16] y; 54% men) were consecutively examined, including the PRUNE-S (retest:
OBJECTIVE: To estimate the prevalence and predictors of sustained remission (SR) in patients with psoriatic arthritis (PsA) receiving biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in Sweden. METHODS: All patients with PsA initiating b/tsDMARDs and who were registered in the national Swedish Rheumatology Quality Register (SRQ) from April 1999 to December 2019 wer
Background and aimMany patients with depressive disorders do not improve with first-line treatment with selective serotonin inhibitors (SSRIs). Adverse drug reactions (ADRs) are common. However, there are no reliable methods to predict treatment response.The general aim of this thesis was to investigate the role of peripheral serotonin and the polymorphic CYP2D6 gene as potential biomarkers of tre
Background: The impact of surgical specialization on long-term survival in patients undergoing emergent colon cancer resections remains unclear. Method: A retrospective analysis was conducted on all patients who underwent emergent colon cancer resections at a secondary care hospital between 2010 and 2020. The most senior surgeon performing the procedures was classified as colorectal surgeon (CS) o
Climate warming is expected to influence the prevalence of vector-transmitted parasites. Understanding the extent to which this is ongoing, or has already occurred, requires empirical data from populations monitored over long periods of time, but these studies are sparse. Further, vector-disease research involving human health is often influenced by disease control efforts that supersede natural t
