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Changes in the tropical hydrological cycle have been recorded world wide in speleothem records dating back more than 200,000 years for some areas. Numerous empirical and modelling studies have demonstrated a strong link between the intensity of the northern hemisphere monsoon and the precessional insolation cycle (similar to 23 ka (thousand years)). Here we present simulations of the climate condi
The study investigates teratogenic risks with ondansetron (Zofran(®)). Data from the Swedish Medical Birth Register combined with the Swedish Register of Prescribed Drugs were used to identify 1349 infants born of women who had taken ondansetron in early pregnancy, 1998-2012. Presence of congenital malformations in the offspring was identified with three national health registers. In a Mantel-Haen
Sweden has expressed a commitment to children’s rights in the last few decades, signing the UN Convention on the Rights of the Child (UNCRC) in 1990 and eventually incorporating it as Swedish law in 2020. With the Covid-19 pandemic coinciding with the convention as law and drastically changing the lives of many, including those of children and youth, what role do children’s rights play during a gl
Gastroparesis, characterized by delayed gastric emptying without mechanical obstruction, is a recognized complication of long-standing diabetes. Its pathophysiology involves, amongst other mechanisms, autonomic dysfunction due to vagal nerve damage, impaired smooth muscle contractility, and hormonal dysregulation of intestinal motility. During Ramadan, fasting causes significant dietary changes du
Cycle injection schemes are often encountered in underground hydrogen storage (UHS), and the involved hysteresis directly impacts storage and extraction efficiency. The geological formation generally has hierarchical features containing multiple-level pore sizes. Nevertheless, we still lack a comprehensive understanding of this phenomenon and the pore-scale mechanism behind the geometry affects sa
Recent studies on parallel evolution have focused on the relative role of selection and historical contingency during adaptive divergence. Here, we study geographically separate and genetically independent lake populations of a freshwater isopod (Asellus aquaticus) in southern Sweden. In two of these lakes, a novel habitat was rapidly colonized by isopods from a source habitat. Rapid phenotypic ch
Atrial electrical and contractile remodeling have been demonstrated to coincide during atrial fibrillation (AF) in experimental studies. We explored whether electrical and contractile remodeling correlate in man and explored its clinical implications. METHODS: Forty-nine patients with persistent AF were studied. Electrical remodeling was assessed noninvasively using spectral analysis to estimate t
Popular Abstract in Swedish Den första beskrivningen av diabetes mellitus gjordes redan 1500 före Kristus när en faraos läkare noterade att myror samlade sig omkring urin från vissa människor men inte andras. På 1700-talet beskrevs för första gången närvaron av större mängder socker i såväl blod som urin hos diabetiska patienter. På 1920-talet upptäcktes insulin i bukspottkörteln (pancreas) och saThe influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in t
An increase in student activity is the goal of various pedagogic approaches and highly valued in most teaching situations. The benefits of student activation are widely discussed in literature (Fox, 1983), but possible drawbacks of such techniques need to be identified and compensations need to be found. This paper discusses a case study concerning one particular course moment, a seminar, held ove
Migratory birds can use a magnetic compass for orientation during their migratory journeys covering thousands of kilometers. But how do they sense the reference direction provided by the Earth's magnetic field? Behavioral evidence and theoretical considerations have suggested that radical-pair processes in differently oriented, light-sensitive molecules of the retina could enable migratory birds t
The current event-related fMRI study examined the relative involvement of different parts of the medial temporal lobe (MTL), particularly the contribution of hippocampus and perirhinal cortex, in either intentional or incidental recognition of famous faces in contrast to unfamiliar faces. Our intention was to further explore the controversial contribution of MTL in the processing of semantic memor
Objectives To study the prevalence and incidence of elevated liver enzymes and their relationship with body weight, metabolic factors and other diseases in Turner syndrome (TS). Design Five-year follow-up. Patients Women with TS (n = 218, mean age 33 +/- 13, range 16-71 years) from outpatient clinics at university hospitals in Sweden. Measurements Fasting blood samples for aspartate (AST) and alan
Twenty-four children (aged 5 months to 18 years) who were admitted to a university hospital were observed for a total of 135 hours with the aim of describing their degree of participation in decisions concerning their own care. Grading of their participation was made by using a 5-point scale. An assessment was also made of what was considered as optimal participation in each situation. The results
Image and flow cytometry was used to study the nuclear DNA content (ploidy) during the squamous cell carcinogenesis in the esophagus. The present retrospective study comprised 26 surgical specimens of squamous cell carcinomas (SCC) in patients who underwent surgery alone at the Department of Surgery in CHUV Hospital in Lausanne, between January 1992 and December 1999. We analyzed 53 healthy tissue
Respiratory system resistance (R) and elastance (E) are commonly estimated by fitting the linear equation of motion P = EV + R(V) over dot + P-0 (Eq. 1) to measurements of respiratory pressure (P), lung volume (V), and flow (V). However, the respiratory system is unlikely to behave linearly under many circumstances. We determined the importance of respiratory system nonlinearities in two groups of
