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BACKGROUND: An increasing number of monogenic conditions underlying stroke are being identified. We explored the possibilities of increasing the diagnostic yield of monogenic stroke in a population under 56 years of age. METHODS: Fifty probands ≤55 years at their first stroke episode were characterized clinically and investigated by whole genome sequencing. Probands had one or more of: (1) one or
PURPOSE: Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced relapse risk.METHODSPatients with MDS planned for HSCT were enrolled in a prospective, observational study evaluating the association b
Capsazepine is known as a transient receptor potential channel vanilloid subfamily 1 (TRPV1) antagonist that inhibits bronchoconstriction evoked in animals by TRPV1 agonists. In this study, effects of capsazepine and chemically related analogues, so called capsazepinoids, were examined in vitro on contractile effects in human small airway preparations. Repeated cycles with 1 h of LTD4-free physiol
Background: Childhood cancer predisposition (ChiCaP) syndromes are increasingly recognized as contributing factors to childhood cancer development. Yet, due to variable availability of germline testing, many children with ChiCaP might go undetected today. We report results from the nationwide and prospective ChiCaP study that investigated diagnostic yield and clinical impact of integrating germlin
A new encapsulation strategy for probiotics is highly needed to tackle the challenge of significant viability loss of bacteria during storage and passage through the gastrointestinal system. A new controlled delivery system for probiotics based on EC oleogels is proposed in this thesis. A relatively non-complicated in vitro lipolysis model was established to evaluate the relative conversion from t
Eco-roofs are becoming popular for aesthetic reasons and also as units of stormwater systems. It is thought that such roofs with soil cover and vegetation reduces the total runoff, the peak flows and improves the quality of the roof water. Here are reported investigations of runoff from thin, 3-4 cm soil, extensive green roofs with sedum-moss in southern Sweden. The two-year study was performed on
This study develops a framework for spatiotemporal modeling of dust storm source susceptibility in a critical case study, the Tigris-Euphrates River Basin, as a significant source of dust storms in the Middle East. The study period was divided into four periods, 2000–2004 (hydrological dry year), 2005–2007 (hydrological wet year), 2008–2012 (hydrological dry year), and 2013–2021 (hydrological wet
Background and Objective: The number of reports on suspected drug-induced memory impairment submitted to the US Food and Drug Administration increased 30-fold from 2000 to 2022. Drugs are the most common cause of reversible dementia. However, there is very little research on drug-induced cognitive impairment. The aim of this study was to investigate if and how an assessment of cognitive safety was
Background: People with intellectual disabilities (ID) may be at higher risk of psychiatric disorders than the general population. However, few studies investigate the role of demographic factors.Methods: This register-based study includes all people living in Skåne, Sweden, on January 1st, 2014. The ID cohort comprises those who received support and service for people with functional impairments
Monitoring agricultural land with optical remote sensing offers a valuable tool for estimating crop yield and supporting decision-making for food security. Cropland phenology indicators, such as the start of season (SOS), the end of season (EOS), and the number of growing seasons per year, provide essential information for land managers. While established toolboxes like TIMESAT have been extractin
The Natural Resources Conservation Service Curve Number method (NRCS-CN) is the most widely used approach to estimate runoff from rainfall events. However, some uncertainties in the method remain linked to the value of the standard initial abstraction ratio (λ) and discrepancies between computed and standard tabulated Curve Number (CN) values. Here, we compute CN values and investigate the effects
Introduction: The screening program for cervical cancer in Sweden recommends the use of primary human papillomavirus (HPV) screening for women aged ≥30 to 65 years. Co-testing with both HPV analysis and cytology is recommended at the first screening after the age of 40 years. To fulfil co-testing, all screened women aged 40–42 years within the region of Skåne were co-tested. The aim of the audit w
Background Tuberculosis is among the leading causes of death among infectious diseases. Regions with a high incidence of tuberculosis, such as sub-Saharan Africa, are disproportionately burdened by stillbirth and other pregnancy complications. Active tuberculosis increases the risk of pregnancy complications, but the association between latent tuberculosis infection (LTBI) and pregnancy outcomes i
Purpose: Although persistent offenders with histories of imprisonment and violence have disproportionate high rates of psychiatric disorders, little is known of their psychiatric healthcare utilization (HCU) and HCU-associated factors. This study aimed to explore psychiatric HCU, psychiatric morbidity, and psychotropic prescription drugs in violent offenders with a history of incarceration. Method
Diabetes mellitus (DM) incidence have been assessed in connection with air pollution exposure in several studies; however, few have investigated associations with source-specific local emissions. This study aims to estimate the risk of DM incidence associated with source-specific air pollution in a Swedish cohort with relatively low exposure. Individuals in the Västerbotten intervention programme
Climate change is a fact and the potential climate change impacts on infrastructure are necessary to examine to ensure the safety and performance of societies. The evidence for climate change is overwhelming, the changes have been observed and the projected future based on models indicate further change. Several of the climate change impacts are predictable, though the magnitude of the changes is
Hydropower is simply the largest source of renewable energy in the Nordic countries, where It compose around 90% of power production in Iceland, 70% in Norway, 40% in Sweden and 20% in Finland. Mountainous terrain and abundance in the surface water is a significant contributing factor in hydropower production. Hydropower is also considered more reliable and continuous than other forms of renewable
Studien syftar till att beräkna det gröna, blå och grå vattenfotavtrycket vid odling och produktion av höstvete och tre fallstudier av höstvete-produkter; drivmedelsetanol, kärnvetemjöl och makaroner. Beräkningarna har utförts för Sverige under perioden 2008-2010 och täcker ungefär 80 % av den svenska produktionen av höstvete under de berörda åren. Södra Sverige delades in i 18 klimatzoner för vilThis study attempts to calculate the green blue and gray water footprint of the crop production of winter wheat and three derived winter wheat products: liquid fuel ethanol, wheat flour and macaroni. The calculations were done for Sweden for the period 2008-2010, covering an average of 80% of the annual winter wheat production. The south of Sweden was divided into 18 climate zones for which suffic
This study used the urban context of Brunnshög, Sweden as a real case study to assess non-visual daylight conditions in urban environments. More precisely, the work was focusing on how the light spectrum – through surrounding façade colour and window type – can have an impact on the circadian potential. A one-bedroom apartment opening onto a courtyard on the ground floor and the same apartment on
Försörjning av varor och tjänster är en grundläggande del av ett fungerande samhälle, och stora delar av denna försörjning sker genom näringslivet och kritiska infrastrukturer. Hot i form av klimatförändringar och antagonistiska handlingar är centrala aspekter att beakta i utformningen av viktiga samhällsfunktioner för att kunna förebygga och hantera kriser. Under de senaste 10-15 åren har klimataThe supply of goods and services is a fundamental part of a functional society, and most of this supply is driven by businesses and critical infrastructures. In the shaping of vital societal functions, threats like climate change and antagonistic acts are central aspects to consider to prevent and manage potential crises. In the last 10-15 years, climate change adaption has become a tool for mitig
