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In the β-d-galactopyranoside-binding protein galectin-3, synthetic inhibitors substituted at the 3-position of a thiodigalactoside core cause the formation of an aglycone binding pocket through the displacement of an arginine residue (Arg144) from its position in the apoprotein. To examine in detail the role of different molecular interactions in this pocket, we have synthesized a series of nine 3

Cyanobacteria in fresh water can cause serious threats to drinking water supplies. Managing cyanobacterial blooms particularly at small drinking water treatment plants is challenging. Because large amount of cyanobacteria may cause clogging in the treatment process and various cyanotoxins are hard to remove, while they may cause severe health problems. There is lack of instructions of what cyanoba

This dissertation investigates how history is produced, what roles it plays, and what forms it takes in four Swedish football clubs – AIK, Djurgårdens IF, Helsingborgs IF and Malmö FF. The overreaching aim is to describe and analyse how history is produced and performed in football clubs, and the implications this development has for football and for the understanding of history. The focus is on h

For many polar organic micropollutants, biotransformation by activated sludge microorganisms is a major removal process during wastewater treatment. However, our current understanding of how wastewater treatment operations influence microbial communities and their micropollutant biotransformation potential is limited, leaving major parts of observed variability in biotransformation rates across tr

Purpose: The purpose of the study, upon which this paper is based, was to contribute an improved understanding of the vertical extension of buildings, by presenting a development process for its implementation in which the key aspects to consider when planning such extensions are highlighted. Design/methodology/approach: The approach is based on linking the diffusion of innovation together with ca

Portugal is located in the southwest of Europe. From economic, cultural, social and environmental point of views, Portuguese coastal areas face multiple challenges related to the coastal management policy, the functionality of the governmental services and the responses to the society, in particular, to the affected citizens. Qualitative and quantitative understanding of the coastal morphological

Building more energy-efficient and sustainable urban areas that will both mitigate the effects of climate change and anticipate living conditions in future climate scenarios requires the development of new tools and methods that can help urban planners, architects and communities achieve this goal. In the current study, we designed a workflow that links different methodologies developed separately

Direct ground cooling (DGC) is a method used in cold climates to provide cooling to buildings without the use of any mechanical refrigeration. When DGC is utilized for providing cooling, ground-source heat pumps (GSHPs) and district heating (DH) are the two commonly used technologies for providing heating to the buildings. This article investigates the coupling of DGC with GSHPs and DH in terms of

The continuous increase in global energy consumption has led to a greater focus on the energy required for heating buildings. This thesis presents a techno-economic model for analysing low-temperature district heating networks coupled with a geothermal heat source. The model was used to analyse an existing system in Denmark with 15 connected single-family detached houses. Each of the houses has a

Flooding is a natural but unavoidable disaster that occurs over time. Flooding threatens human life, property, and resources and affects regional and national economies. Through frequency ratio and MaxEnt modeling, flood sensitivity was determined in the Amu Darya River Basin in Badakhshan Province, Afghanistan. Slope, plan curvature, distance to river, rainfall, aspect, land use, elevation, Norma

Pandemics such as Covid-19 have posed a set of questions concerning safe space usage given the risk of virus transmission in confined and open spaces. In this context, this report presents a risk analysis methodology for the use of crowd modelling tools as an aid to assess safety in confined and open spaces. Crowd models can be used to investigate people movement in the built environment, thus the

Integration of disaster risk reduction (DRR) and climate change adaptation (CCA) is widely recognized as a solution for reducing the risk and impacts of disasters. However, successful integration seems elusive, and the two goals continue to function in isolation and in parallel. This article provides empirical insights into the perceived effects of separating government institutions for DRR and CC

Malignant melanoma is one of the most aggressive skin cancers with high potential of visceral dissemination. Since the information about melanoma genomics is mainly based on primary tumors and lymphatic or skin metastases, an autopsy-based visceral metastasis biobank was established. We used copy number variation arrays (N = 38 samples) to reveal organ specific alterations. Results were partly com

Serialization is an old narrative strategy and a form of publication that can be traced far back in literary history, yet serial narratives are as popular as ever. This book investigates a resurgence of serial narratives in contemporary literary culture.Analyzing series as diverse as Mark Z. Danielewski’s experimental book series The Familiar; audiobook series by the Swedish streaming service Stor

Current sustainability assessment (SA) tools to help deal with contaminated groundwater sites are inherently subjective and hardly applied. One reason may be lack of proper tools for addressing contaminant spread which are basically objective. To fill this gap, there is a need for contaminant transport models that provide site managers with needed room for applying their judgments and consideratio

Exposure of cells to adverse environmental conditions invokes a genetically programmed series of events resulting in the induction of specific genes. The fluoroquinolone antibiotic ciprofloxacin has recently been reported to upregulate interleukin-2 (IL-2) gene induction. In the present investigation, the effect of ciprofloxacin at supratherapeutic concentrations on immediate-early (<2 h) gene exp

The current climate change is calling for a drastic reduction of energy demand as well as of greenhouse gases. Besides this, cities also need to adapt to face the challenges related to climate change. Cities, with their complex urban texture and fabric, can be represented as a diverse ecosystem that does not have a clear and defined boundary. Multiple software tools that have been developed, in re

Global gridded crop models (GGCMs) combine agronomic or plant growth models with gridded spatial input data to estimate spatially explicit crop yields and agricultural externalities at the global scale. Differences in GGCM outputs arise from the use of different biophysical models, setups, and input data. GGCM ensembles are frequently employed to bracket uncertainties in impact studies without inv

In the present paper, an approach for updating the continuous stress range distribution of a welded connection of a wind turbine support structure with predicted information from strain measurements is presented. Environmental conditions, such as wind or, in offshore fields, waves and currents, in combination with rotor excitations generate cyclic stresses affecting the reliability of welded joint

This study investigates the use of a direct ground cooling system (DGCS) using active chilled beams for the cooling of office buildings in Sweden. The methodology of the study entails laboratory experiments to develop and validate a simulation model of the cooling system. The sensitivity of the input parameters, such as borehole heat exchanger (BHE) length, internal heat gains and room temperature