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Background: Potent antithrombotic therapy has significantly improved prognosis for patients with acute myocardial infarction (AMI), however, at a price of increased bleeding risk. Chronic gastric infection with Helicobacter pylori (Hp) commonly causes upper gastrointestinal bleeding and is proposed as a risk factor for subsequent bleeding post AMI. The prevalence of active Hp in a current AMI popu
Mineralogical and geochemical studies of the non-marine Permian–Triassic (P–Tr) boundary across two stratigraphically wellconstrained sections (Commando Drift Dam and Wapadsberg, Eastern Cape Province) in the southern Karoo Basin, South Africa, have been undertaken to provide further input on the cause of this mass extinction event, and so has a sedimentological and geochemical evaluation of a thi
Purpose: To determine progression factors at the end of the Early Manifest Glaucoma Trial (EMGT) based on all EMGT patients and evaluate separately patients with higher and lower baseline intraocular pressure (IOP; median split). Design: Cohort of clinical trial participants. Participants: Patients with early open-angle glaucoma randomized to argon laser trabeculoplasty plus betaxolol (n = 129) or
The dogroses (Rosa Sect. Caninae) are characterized by a unique meiosis - the canina meiosis - that results in restricted recombination. In the present study, we investigate population differentiation and morphometric diversity within six taxa, of Nordic dogroses, with the help of automated image analysis of leaflet shape and manually-measured reproductive characters. The total morphometric divers
BACKGROUND: The use of nitrous oxide (N2O) during hemodilution has been questioned. Nitrous oxide reduces the inspired oxygen fraction (F1O2), depresses myocardial function and may reduce cardiac output (CO) and systemic oxygen delivery (DO2SY). The aim of this study was to evaluate the importance of the effects of nitrous oxide on systemic and myocardial circulation and oxygenation during extreme
BACKGROUND: Short body height is associated with increased risk for coronary heart disease; however, mechanisms are not fully explained. In this study, associations between body height and serum cholesterol, non-high-density lipoprotein (non-HDL cholesterol) and high-density lipoprotein (HDL cholesterol) were investigated. METHODS: Prospective cohort study of middle-aged men from Helsingborg, Swed
Building more energy-efficient and sustainable urban areas that will both mitigate the effects of climate change and anticipate living conditions in future climate scenarios requires the development of new tools and methods that can help urban planners, architects and communities achieve this goal. In the current study, we designed a workflow that links different methodologies developed separately
Chronic pain including temporomandibular disorder (TMD) pain involves a complex interplay between peripheral and central sensitization, endogenous modulatory pathways, cortical processing and integration and numerous psychological, behavioral and social factors. The aim of this study was to compare spectroscopic patterns of N-Acetyl-aspartate (NAA), total creatine (tCr), choline (Cho), myo-inosito
Context. X-ray extragalactic surveys are ideal laboratories for the study of the evolution and clustering of active galactic nuclei (AGN). Usually, a combination of deep and wide surveys is necessary to create a complete picture of the population. Deep X-ray surveys provide the faint population at high redshift, while wide surveys provide the rare bright sources. Nevertheless, very wide area surve
In biomarker analysis, sample preparation plays a crucial step in order to extract, isolate and concentrate the analytes of interest. Among the various sample preparation techniques, solid phase extraction (SPE) is one of the most common and popular, due to the high enrichment factor, good recovery, low consumption of organic solvents and the possibility to automate (off- or on-line) the whole pro
AbstractPhysical exhaustion can constrain human ascending work capacity and performance during emergency evacuation on stairs. The overall aim of this research was to explore and compare stair ascending capacities and physiological limitations during two different strategies: self-preferred pace in three different public stairways in the field, and controlled pace in a laboratory on a stair machin
Background: The relationship between dyslipidemia, inflammation and CV organ damage in type 2 diabetes mellitus (T2DM) is complex. Insulin resistance and inflammatory cytokines interleukins (ILs) increase plasma triglycerides (TG). ILs also up-regulate expression of matrix-metalloproteinases (MMPs) that, together with TG, decrease high density lipoprotein cholesterol (HDL) levels. High TG, low HDL
Popular Abstract in Swedish De flesta produkter som vi dagligen använder tillverkas genom att utnyttja fossila råvaror som olja, kol och naturgas. Ett stort problem är att dessa råvaror bara finns i begränsade mängder i naturen, vilket medför att de förr eller senare tar slut. Dessutom medför förbränning av fossila råvaror att det bildas miljöskadande gaser (t.ex. koldioxid) som ansamlas i atmosfäOne of the major challenges facing the world today is the reduction of our dependency on fossil resources as their exploitation has severe negative effects on the environment. One way of realizing this is to utilise the components of lignocellulosic biomass to a greater extent as feedstock for various industrial products. However, such utilisation requires the extraction of the biopolymers from th
The presented thesis work is concerned with the study of molecular dynamics using liquid nuclear magnetic resonance (NMR) spectroscopy. Spin relaxation dispersion experiments in the rotating frame (R1ρ) are employed to provide a detailed, atomic-resolution view of protein dynamics. Comprehensive investigations of 15N backbone and 13C methyl side-chain confo
Acute myeloid leukemia (AML) is a heterogeneous disease of the myeloid lineage. About 35% of AML patients carry an oncogenic FLT3 mutant making FLT3 an attractive target for treatment of AML. Major problems in the development of FLT3 inhibitors include lack of specificity, poor response and development of a resistant phenotype upon treatment. Further understanding of FLT3 signaling and discovery o
Popular Abstract in Swedish Parallellt med att kommunerna under 1990-talet fick ett utvidgat ansvar för t.ex. vården av och omsorgen om äldre och funktionshindrade gavs de större frihet att lokalt bestämma över sina organisationsformer. Omständigheterna ledde till ett starkt kommunalt reformtryck, inte minst genom de reformförslag som på olika sätt och i varierande grad utmanade den traditionella The 1990s was a period characterized by a strong pressure for reform in the Swedish municipalities. The care manager reform, i.e. the initiation of a position within the administration - the care manager - whose work tasks are concentrated around needs-assessment practices only, was one of many reform proposals. Within a fairly short time span a great number of municipalities decided to implement
The immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome is a rare autosomal recessive disease. Usually, it is caused by mutations in the DNA methyltransferase 3B gene, which result in decreased methylation of satellite DNA in the juxtacentromeric heterochromatin at 1qh, 16qh, and 9qh. Satellite II-rich 1qh and 16qh display high frequencies of abnormalities in mitogen-
Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) are assoc
Popular Abstract in Swedish Ny innovativ processdesign har resulterat i två processer som kan göra tillverkningen av förnyelsebara plaster och bränslen konkurrenskraftiga mot dagens fossila alternativ. Den nya designen har gjort vissa processteg upp mot 40 gånger så effektiva som med dagens teknik. Vikten av att ställa om dagens samhälle, som till stor del är beroende av fossila resurser, till eIt is important to replace fossil resources such as oil, coal and natural gas with renewable raw materials for the production of materials and fuels in order to reduce environmental impact. Furthermore, these raw materials should preferably be residues, e.g. agricultural or forest residues, in order not to compete with the production of human food and animal feed. High molecular weight arabinoxyla
A major limitation to clinical stem cell-mediated gene therapy protocols is the low levels of engraftment by transduced progenitors. We report that CXCR4 overexpression on human CD34(+) progenitors using a lentiviral gene transfer technique helped navigate these cells to the murine bone marrow and spleen in response to stromal-derived factor 1 (SDF-1) signaling. Cells overexpressing CXCR4 exhibite
