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Phenotypic drug discovery (PDD) enables the target-agnostic generation of therapeutic drugs with novel mechanisms of action. However, realizing its full potential for biologics discovery requires new technologies to produce antibodies to all, a priori unknown, disease-associated biomolecules. We present a methodology that helps achieve this by integrating computational modeling, differential antib
Background: Evidence concerning the reduction of postoperative complications due to smoking and alcohol drinking in patients undergoing radical cystectomy is incomplete. Objective: To evaluate the efficacy of a 6-wk smoking and/or alcohol cessation intervention, initiated shortly before surgery and continued until 4 wk after, in reducing complications. Design, setting, and participants: Between 20
The overall energy goals mean that more and more extensive measures need to be applied on buildings with varying degrees of heritage value. Previous studies show that there are a number of measures that have a beneficial impact on different parts of the energy system in historic buildings. What is now needed is a holistic approach that provides an opportunity to prioritize which measures are most
Reduced energy consumption is an important strategy for climate change mitigation. Buildings, worldwide, accounts for 40 % of the primary energy use and 24 % of greenhouse gas emissions.There are studies and publications indicating that problems with high indoor temperature during summer are increasing in residential buildings designed as passive houses and low-energy buildings.The objective of th
Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. The majority of CDK2's known meiotic functions occur during prophase of the first meiotic division. Here, CDK2 is involved in the regulation of meiotic transcription, the pairing of homologous chromosomes, and the maturation of meiotic cross
Denna studie syftar till att preliminärt utvärdera förändringar i risken för cyanobakteriella blomningar i en eutrof sjö, Vombsjön, som ligger i södra Sverige och testa hur näringsämnen (fosfor och kväve) påverkar algväxten. Ytvatten som sjöar har stor betydelse för dricksvattenförsörjningen, till exempel hälften av dricksvattnet i Sverige är från ytvatten. Enligt riskmatrisen har Vombsjön en storThis study aims to preliminarily evaluate changes in the risk of cyanobacterial blooms in a eutrophic lake, Lake Vombsjön, in the southern Sweden and test the role of nutrients (phosphorus and nitrogen) in algae formation. Surface water such as lakes service great importance for drinking water supply, such as half of the drinking water in Sweden is from surface water. According to risk matrix, Lak
This study concerns the management functions, institutional and legal frameworks to foster IRBM in the Yangtze River Basin. It is implemented as part of the EU China River Basin Management Programme funded by the EU.The overall objective of the study is to contribute to an enabling framework of policies, legislation and institutions that will promote IRBM in China and assist the government to harm
This project consists of a thorough study of an energy efficient and moisture safe row-house, located in the Nordic climate of Sweden. Climate and site analysis, building scale design decisions and finally the evaluation and optimization of its energy performance were different steps of a holistic process aiming at the architectural quality, energy efficiency, comfort and the well-being of users.
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (50% of these regi
An experimental analysis of the fire behavior of stone wool composites with stainless steel and gypsum plasterboard linings was performed. The focus was to characterize the micro-scale behavior of stone wool, and identify the main processes occurring in stone wool composites when exposed to heat. Thermogravimetric analysis was applied to two different wools with varying densities and binder conten
AbstractThe overall aim of this thesis was threefold; first, to explore resources associated with work-life balance (WLB), with a focus on the work and private lives of human service employees. Second, to develop a workplace health promotion (WHP) intervention with a WLB focus. Third, to explore the participants’ experiences of the developed WHP intervention done in the workplace. A mixed method a
Introduction: Home-based, clinically feasible trials in non–dialysis-dependent patients with chronic kidney disease (CKD) are sparse. We compared the effects of 2 different exercise training programs on physical performance, and measured glomerular filtration rate (mGFR) and albuminuria level in patients with CKD stages 3 to 5. Methods: Thi
Ground improvement with lime-cement pillars is becoming increasingly common in the Nordic countries for exploitation of areas with poor stability. However, there is no non-destructive method for quality control of the ground improvement. Significant changes in the electrical properties after mixing of the binders make electrical resistivity tomography (ERT) a potential method. In connection with l
Oxidation-reduction potential (ORP) is an environmental factor of importance in several biological conversion processes. Lytic polysaccharide monooxygenases (LPMOs) catalyze oxidative disruption of the cellulose chain in the presence of oxygen or hydrogen peroxide and increase enzymatic hydrolysis yields. However, the enzymes are also sensitive to oxidative damage and the level of oxidative agent
What are core values and what use are they? How can the central governmentcore values translate to academia? Why do the ‘statutory’, political valuesend up in conflict with academic values based on the specific culture ofuniversities? What methods and what examples exist for active and effectivecore values work at a university? And how do you implement core values sothat they are present and meani
Extracellular vesicles (EVs) are a heterogeneous group of actively released vesicles originating from a wide range of cell types. Characterization of these EVs and their proteomes in the human plasma provides a novel approach in clinical diagnostics, as they reflect physiological and pathological states. However, EV isolation is technically challenging with the current methods having several disad
Textile industries are responsible for one of the major environmental pollution problems in the world, because they release undesirable dye effluents. Textile wastewater contains dyes mixed with various contaminants at a variety of ranges. Therefore, environmental legislation commonly obligates textile factories to treat these effluents before discharge into the receiving watercourses. The treatme
Conventional wastewater treatment plants are designed for treating manmade wastewater (e.g., from households and industries) and to protect the environment (e.g., receiving water bodies) and humans from adverse effects.The objective of this work was to investigate the feasibility of treating municipal wastewater without a biological treatment step by applying different separation processes, such a
Under 2012–2014 organiserade VIWAFU, ett nätverk för internationellt och interdisciplinärt forskarsamarbete i Norden och Baltikum, fyra seminarier för master-studenter, doktorander och post-docs. Var och ett av seminarierna hade ett tema, t.ex. VA-branschens reglering och styrning, infrastruktur för dricksvatten, innovativ utveckling inom kommunala vattenfrågor samt vattenhantering Viable Water Management and Governance for Futures (VIWAFU), a professional network for international and interdisciplinary collaboration amongst researchers from the Nordic and Baltic countries, was built for providing and sharing knowledge on water management and governance for future policy and decision making during the years 2012–2014. VIWAFU organized four workshops for MSc stud
OBJECTIVES: Assessing the burden of maternal mortality is important for tracking progress and identifying public health gaps. This paper provides an overview of the burden of maternal mortality in the Eastern Mediterranean Region (EMR) by underlying cause and age from 1990 to 2015.METHODS: We used the results of the Global Burden of Disease 2015 study to explore maternal mortality in the EMR count
