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This study characterizes the high-fat diet-fed mouse as a model for impaired glucose tolerance (IGT) and type 2 diabetes. Female C57BL/6J mice were fed a high-fat diet (58% energy by fat) or a normal diet (11% fat). Body weight was higher in mice fed the high-fat diet already after the first week, due to higher dietary intake in combination with lower metabolic efficiency. Circulating glucose incr
Research conducted over the last 50 years has produced discoveries on the importance of glucose control for reducing the risk of diabetic complications, the pathophysiology of type 2 diabetes, the development and validation of mechanistic glucose-lowering targets, and the preclinical and clinical development of individual drugs. This science established the different drug classes that are clinical
Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can cause a rare form of diabetes. However, it is unclear whether mitochondrial dysfunction is a primary cause of the common form of diabetes. To date, common genetic variants robustly associated with type 2 diabetes (T2D) a
Dietary fats could affect glucose metabolism and obesity development and, thereby, may have a crucial role in the cause of type 2 diabetes (T2D). Studies indicated that replacing saturated with unsaturated fats might be favorable, and plant foods might be a better choice than animal foods. Nevertheless, epidemiologic studies suggested that dairy foods are protective.
Popular Abstract in German Spannungsgesteuerte Kalziumkanäle haben eine große Bedeutung in vielen elektrisch erregbaren Zellen, wie z.B. in Nervenzellen und pankreatischen beta-Zellen. Hier werden sie folgendermaßen aktiviert: In der Nahrung enthaltener Traubenzucker (Glukose) wird nach einer Mahlzeit über den Blutstrom im Körper verteilt und in die beta-Zellen über Glukosetransporter aufgenommen.Voltage-gated Ca2+ channels are essential transducers of cellular signals in many electrically excitable cells. In the pancreatic beta-cell they mediate controlled Ca2+ influx, which is the final trigger for Ca2+ dependent release (exocytosis) of the blood glucose lowering hormone insulin. Several subtypes of voltage-gated Ca2+ channels are known and the L-type has been found to be the main contri
OBJECTIVE - The purpose of this study was to assess the efficacy of the postload plasma glucose concentration in predicting future risk of type 2 diabetes, compared with prediction models based oil measurement. of the fasting plasma glucose (FPG) concentration. RESEARCH DESIGN AND METHODS - A total of 2,442 subjects from the Botnia Study, who were free Of type 2 diabetes at baseline, received an o
Barn som far illa, eller riskerar att fara illa, kan i Sverige tvångsomhändertas och beredas vård enligt lag (1990:52) med särskilda bestämmelser om vård av unga (LVU). I lagstiftningen skiljer man på så kallade miljöfall och beteendefall. Med miljöfall avses fall där problemen och omständigheterna som föranleder ett ingripande finns i barnets omgivning, såsom att barnet blivit utsatt för misshand
Nocturia, the urge to wake from sleep to void, is targeted sub-optimally by existing drugs that modulate circadian dysregulation of urine production in kidney without alleviating detrusor overactivity, a key aspect in the multifactorial etiology of nocturia. This study reports age-related upregulation of arginine vasopressin (AVP) synthesis in mouse urinary bladder to counter the concurrent declin
Cystitis is a bacterial infection of the bladder that occurs in about half of women at least once in their lifetime. Antibiotics such as nitrofurantoin are used to treat cystitis, but antibiotic resistance is a concern, especially for recurrent infections. Here we report an open-label, randomized, single-centre, phase 2 study to analyse the acute and long-term safety and efficacy of the IL-1 recep
Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. The risk allele leads to receptor overexpression in β-cells that causes increased adrenergic signaling and impaired insulin secretion. We showed that the α2A-adrenergic receptor an
The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is a dual-hemisphere, near-infrared (NIR), spectroscopic survey with the goal of producing a chemodynamical mapping of the Milky Way. The targeting for APOGEE-2 is complex and has evolved with time. In this paper, we present the updates and additions to the initial targeting strategy for APOGEE-2N presented in Zasowski et al.
Background: The global burden of cardiovascular disease and type 2 diabetes could be decreased by improving dietary factors, but identification of groups suitable for interventional approaches can be difficult. Reporting of dietary intake is prone to errors, and measuring of metabolites has shown promise in determining habitual dietary intake. Our aim is to create a metabolic signature that is ass
Objectives. To design protocols for specific and quantitative immunohistochemical detection of human kallikrein 2 (hK2) using lanthanide chelate-labeled monoclonal antibodies (Mabs) and time-resolved fluorescence imaging. Methods. Anti-prostate-specific antigen (PSA) Mabs were tested in microtiterplate assays for their ability to prevent PSA from cross-reacting with the anti-hK2 Mab 6H10. Europium
Kulturskolepedagog 90 hp Kulturskolepedagog 90 hp MUSIK/KONST/SCENKONST TERMIN 1 En kulturskola för alla, 3hp KUSE15 Inkluderande och specialpedagogiska perspektiv i kulturskolan, 7,5hp KUSE10 Kulturskolan som idé och praktik 1, 7,5hp KUSE11 Ämnesdidaktik 1, 7,5hp Musik KUSE17 Scenkonst KUSE13 Konst KUSE14 VFU 1, 4,5hp KUSE16 TERMIN 2 Lärande och ledarskap i kulturskolan, 7,5hp KUSE27 Barn och ung
https://www.mhm.lu.se/sites/mhm.lu.se/files/2023-06/O%CC%88versikt_Kulturskolepedagog%2090%20hp.pdf - 2026-07-25
Microsoft Word - RapportEnvariabelanalysVT22.docx Rapport om kursen i Envariabelanalys (MATA21) vårterminen 2022 Under vårterminen 2022 hade Envariabelanalyskursen 85 registrerade studenter varav 24 var omregistrerade. Det var totalt sett 43 studenter som klarade kursen, 38 av de nyregistrerade och 5 av de omregistrerade. Av de studenter som klarade kursen fick 19 stycken betyget VG. Alla studente
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2022/MATA21VT22.pdf - 2026-07-23
Tim Ingold’s critique of mainstream modern experiences of human–environmental relations is highly persuasive but almost completely disconnected from considerations of social relations of power and inequality. His emphasis on the phenomenology of local relations seems inevitably detached from the logic of abstract economic and political systems. This article proposes that the distortions of experie
The 5-HT 7 receptor (5-HT 7 R) is involved in a broad range of physiological conditions and disorders. Currently,
