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The clinical utility of microfluidic techniques is often hampered by an unsatisfying sample throughput. Here, the effect of inertial forces on acoustofluidic particle sorting at high sample throughputs is investigated experimentally and theoretically. Polystyrene particles are acoustically prefocused to obtain precise trajectories. At increased flow rates it is observed that the particle stream is
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Across a wide range of cultural and socio-political contexts, matchmaking has been valued as a legitimate profession that involves labor and remuneration in cultures. It represents the long-lasting commercialization of effective intimacy building. In the era of algorithms and platforms,the emergence of modern matchmaking, such as in mobile dating apps (MDAs), showcases the impact of platformizatio
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Enzymes that affect glycoproteins of the human immune system, and thereby modulate defense responses, are abundant among bacterial pathogens. Two endoglycosidases from the human pathogen Streptococcus pyogenes, EndoS and EndoS2, have recently been shown to hydrolyze N-linked glycans of human IgG. However, detailed characterization and comparison of the hydrolyzing activities have not been performe
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In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses