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Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The aim of this study was thus to investigate a potential role of SIK2 in the regulat
Institutionen för handelsrätt Uppd: 2024-03-20 Tentamensschema februari 2024 - augusti 2024 Datum Kurskod Kursnamn Tid Lokal Tors 1 feb HARG06 Arbetsrätt II, Dugga 8-10 MA9 Ons 7 feb HARN53 Trade, Investment and Sustainability 8-13 EC2:063 HARN54 Intellectual Property and Trade Ons 28 feb HARA71 Kommersiella avtal och köp 8-13 MA8 HARG15 Compliance och risk i affärslivet HARG03 Kommersiell avtalsr
Institutionen för handelsrätt Uppd: 2024-04-12 Tentamensschema februari 2024 - augusti 2024 Datum Kurskod Kursnamn Tid Lokal Tors 1 feb HARG06 Arbetsrätt II, Dugga 8-10 MA9 Ons 7 feb HARN53 Trade, Investment and Sustainability 8-13 EC2:063 HARN54 Intellectual Property and Trade Ons 28 feb HARA71 Kommersiella avtal och köp 8-13 MA8 HARG15 Compliance och risk i affärslivet HARG03 Kommersiell avtalsr
Analytic expressions for the exact bit error probabilities of rate R = 1/2, memory m = 2 convolutional encoders are derived for a maximum-likelihood (ML) decoder and transmission over the binary-symmetric channel (BSC). The resulting expressions are rational functions of the crossover probability of the BSC. In addition to classical nonsystematic encoders without feedback, we consider also recursi
Islet dysfunction - characterized by a combination of defective insulin secretion, inappropriately high glucagon secretion and reduced beta-cell mass - has a central role in the pathophysiology of type 2 diabetes. Several G protein-coupled receptors (GPCRs) expressed in islet beta-cells are known to be involved in the regulation of islet function, and therefore are potential therapeutic targets. T
Type 2 diabetes carries a risk for hypoglycemia, particularly in patients on an intensive glucose control plan as a glucose-lowering strategy, where hypoglycemia may be a limitation for the therapy and also a factor underlying clinical inertia. Glucose-lowering medications that increase circulating insulin in a glucose-independent manner, such as insulin and sulfonylurea therapy, are the most comm
Syftet med denna uppsats var att studera verbala kränkningar som en motsvarighet till vad som beskrivs som psykisk misshandel i Lag (1990:52) med särskilda bestämmelser om vård av unga (LVU). Mitt huvudsakliga undersökningsområde var hur verbala kränkningar i hemmet hanterats vid beslut om förberedande av vård av unga med stöd av 1 och 2 §§ LVU. Jag gjorde en tematisk analys på 8 rättsfall med syfMy aim with this thesis was to study verbal abuse as an equivalent to psychological abuse in The Care of Young Persons Act (LVU). The primary focus was on verbal abuse in the home as a reason to take a child into protective custody according to LVU. I made a thematic analysis on 8 court cases, with the purpose to find how the Social welfare board and County administrative board reasoned, when it c
Syftet med studien har varit att undersöka på vilket sätt distriktssköterskor arbetar för att förebygga utvecklingen av Diabetes typ 2 hos kraftigt överviktiga personer. Sex distriktssköterskor intervjuades. Distriktssköterskorna hade alla ansvar för kostrådgivning och fem av sex hade ansvar för diabetesvården. Resultatet visade att det inte förekom någon utbredd förebyggande verksamhet. De nya re
Higgs boson production with subsequent decay to photons was searched for in the data collected by the DELPHI detector at centre-of-mass energies between 183 GeV and 209 GeV, corresponding to a total integrated luminosity of nearly 650 pb(-1). No evidence for a signal was found, and limits were set on h(0)Z(0) and h(0)A(0) production with h(0) decay to photons. These results were used to exclude re
CONTEXT: Metabolomics has the potential to generate biomarkers that can facilitate understanding relevant pathways in the pathophysiology of type 2 diabetes (T2DM). METHODS: Nontargeted metabolomics was performed, via liquid chromatography-mass spectrometry, in a discovery case-cohort study from the Malmö Preventive Project (MPP), which consisted of 698 metabolically healthy participants, of whom
Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell frag
We report on the status of efforts to improve the reinterpretation of searches and measurements at the LHC in terms of models for new physics, in the context of the LHC Reinterpretation Forum. We detail current experimental offerings in direct searches for new particles, measurements, technical implementations and Open Data, and provide a set of recommendations for further improving the presentati
Aims/hypothesis: The aims of this study were to evaluate systematically the predictive power of comprehensive metabolomics profiles in predicting the future risk of type 2 diabetes, and to identify a panel of the most predictive metabolic markers. Methods: We applied an unbiased systems medicine approach to mine metabolite combinations that provide added value in predicting the future incidence of
Semi-visible jets, with a significant contribution to the event's missing transverse momentum, can arise in strongly interacting dark sectors. This results in an event topology where one of the jets can be aligned with the direction of the missing transverse momentum. The first search for semi-visible jets produced via a t-channel mediator exchange is presented. The analysis uses proton-proton col
The MEDIM study reports that Immigrants from the Middle East to Sweden – independently of other diabetes related risk factors – have a twice as high type 2 diabetes risk as compared to non-immigrated Swedes. Diabetes onset occurs 6 years earlier in this group and is partly explained by family history and/or obesity. But the MEDIM study has identified that Middle Eastern background per se is an ind
BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n =
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami
