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Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data

INTRODUCTION: Tau positron emission tomography (PET) is a reliable neuroimaging technique for assessing regional load of tau pathology in the brain, but its routine clinical use is limited by cost and accessibility barriers. METHODS: We thoroughly investigated the ability of various machine learning models to predict clinically useful tau-PET composites (load and laterality index) from low-cost an

Monitoring temporal trends in spatially structured populations: how should sampling effort be allocated between space and time?

Estimating temporal trends in spatially structured populations has a critical role to play in understanding regional changes in biological populations and developing management strategies. Designing effective monitoring programmes to estimate these trends requires important decisions to be made about how to allocate sampling effort among spatial replicates (i.e. number of sites) and temporal repli

Affärssystembranschen - En studie av branschens förutsättningar

Sammanfattning Titel: Affärssystembranschen - En studie av branschens förutsättningar Författare: Peter Colliander, Jacob Lundblad, Sophie Monsén Handledare: Hans Knutsson Problem: Affärssystembranschen genomgår idag en omvälvande fas då nya aktörer kommer in på marknaden samtidigt som den tekniska utvecklingen går allt fortare och befintliga aktörer ändrar strategier. Konjunkturläget bidrar till

Assessing parameter variability in a photosynthesis model within and between plant functional types using global Fluxnet eddy covariance data

The vegetation component in climate models has advanced since the late 1960s from a uniform prescription of surface parameters to plant functional types (PFTs) PFTs are used in global land-surface models to provide parameter values for every model grid cell With a simple photosynthesis model we derive parameters for all site years within the Fluxnet eddy covariance data set We compare the model pa

Phenology and its role in carbon dioxide exchange processes in northern peatlands

Ecosystem phenology plays an important role in carbon exchange processes and can be derived from continuous records of carbon dioxide (CO2) exchange data. In this study we examined the potential use of phenological indices for characterizing cumulative annual CO2 exchange in four contrasting northern peatland ecosystems. We used the approach of Jonsson and Eklundh (2004) to derive a set of phenolo

Critical evaluation of three cryo-EM structures of particulate methane monooxygenase by quantum refinement

Particulate methane monooxygenase (pMMO) is an enzyme that converts methane into methanol at ambient temperature and pressure. Over the past three decades, the metal content and location of the active site have been highly controversial. Recent single-particle cryogenic electron-microscopy (cryo-EM) structures have furthered this debate. In this study, three cryo-EM structures (PDB entries 7s4h, 7

An experimental and theoretical study of the morphine binding capacity and kinetics of an engineered opioid receptor

Electrochemical real-time monitoring of ligand binding to an engineered opioid receptor specific for morphine is reported. In the particular systems studied, 90% of the binding was found to be completed after only 85-120 s. Thus, the binding kinetics has proven to be more rapid than previously believed. The observed association rate constant for the morphine binding reaction was calculated to be 2

Pollen tablets

2025-12-01 Tablets under production, expected for calibration end of December. 2025-07-29 Test batch expected to arrive for calibration and quality control mid August. 2025-06-12 Our manufacturer are waiting for one tablet ingredient. 2025-01-22 We will produce a test batch with a manufacturer in Sweden. 2024-10-18 We currently have no Lycopodium tablets for sale. Our tablet manufacturer has shut

https://www.geologi.lu.se/service/pollen-tablets - 2026-05-13

Extremely large differences in DFT energies for nitrogenase models

Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen avaiable for other organisms. It contains a complicated MoFe7S9C(homocitrate) cluster in its active site. Many computational studies with density-functional theory (DFT) of the nitrogenase enzyme have been presented, but they do not show any consensus-they do not even agree where the first four protons should be

Incidence and survival of epithelial ovarian, fallopian tube, peritoneal, and undesignated abdominal/pelvic cancers in Sweden 1960–2014 : A population-based cohort study

Background: Despite improved surgical and oncological treatment, ovarian cancer continues to be the most lethal of the gynecologic malignancies. We aimed to analyze survival trends in epithelial ovarian cancer with regard to age, tumor site, and morphology in Sweden 1960 to 2014. Methods: A nationwide population-based study was conducted using data from the Swedish Cancer Registry on 46,350 women

Habitat associations of the Coastal Giant Salamander (Dicamptodon Tenebrosus) at its northern range limit

Knowledge of species-environment associations is critical for the management of threatened amphibian populations facing habitat fragmentation and a restricted range. The Coastal Giant Salamander (Dicamptodon tenebrosus) is subject to habitat degradation from logging and human development and is classified as Threatened at its northern range limit in British Columbia, Canada. We examined habitat as

Påföljder, Microsoft mot Kommissionen

Microsoftdomen grundar sig i att Microsoft vägrat lämna ut interoperabilitetsinformation till en av sina konkurrenter (Sun). Sun menar att detta konstituerar ett missbruk av dominerande ställning och lämnar in ett klagomål till Kommissionen som påbörjar en utredning. Kommissionen börjar dessutom på egen hand utreda huruvida Microsofts integration av Windows Media Player i sitt operativsystem (Wind

Website accessibility

ReachDeckYou can choose to have the content of our webpages or PDF-files read aloud to you by ReachDeck, and save the read pages as MP3 files. ReachDeck also allows you to change the font size, text colour and other settings. ReachDeck is free software that works on smartphones, tablets and laptops. There is no need to download it to your own device first.Click on the link below to enable ReachDec

https://www.lunduniversity.lu.se/about-this-website/accessibility - 2026-05-13

”Men i mitt hemland blir jag kallad för svensk … Sån ironi …” - en kvalitativ studie om hur kosovoalbaner förhåller sig till sin identitet

Inom identitetsforskning finns det olika definitioner av identitet. För att få en djupare förståelse för begreppet identitet, har jag valt att undersöka hur kosovoalbaner förhåller sig till sin identitet i ett svenskt samhälle. De empiriska uppgifterna samlades in genom kvalitativa semi-strukturerade intervjuer. Min analys baserades på begreppen identitet, tillhörighet och kultur. Baserat på det e

Generalization of prostate cancer classification for multiple sites using deep learning

Deep learning has the potential to drastically increase the accuracy and efficiency of prostate cancer diagnosis, which would be of uttermost use. Today the diagnosis is determined manually from H&E stained specimens using a light microscope. In this paper several different approaches based on convolutional neural networks for prostate cancer classification are presented and compared, using th

Intrinsic subtypes and prognostic implications in epithelial ovarian cancer

Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. However, ovarian cancer is a heterogeneous disease comprising different disease entities, which is of importance in clinical decision-mak

Modelling Mössbauer spectra of biotite

Populärvetenskaplig sammanfattning: Mössbauerspektra är en metod som används för att bestämma hur ett mineral, eller molekyl, är uppbyggt. Man undersöker ett visst grundämne, inom geologin undersöker man oftast järn. Efter att ha analyserat ett prov i spektrometern kan man få uppgifter om var och hur järnet sitter i mineralet, eller molekylen. Metoden bygger på att man skickar gammastrålning av eThe Mössbauer effect is used in this work to determine the oxidation and site occupation in biotites that have been treated in different pHs. The work also gives an introduction to the theory behind the Mössbauer effect as well as Mössbauer spectroscopy. It is obvious that the pH has a significant role in the oxidation of the biotites, the more acidic the sample the more it will be oxidised. It is

Transferability of Online Store Image- A Comparative Study of Zalando's Online Store Image In Germany, Sweden and The Netherlands.pdf

Purpose: The purpose of this thesis is to examine the role of online store image in the internationalization process of online retailers. Based on the assumption that a favorable image is a competitive advantage for retailers, this master thesis examines whether or not a favorable domestic online store image, can be replicated in the in- ternationalization process of online retailers. Using a comp