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Popular Abstract in Swedish Då reumatisk värk och artros är en växande folksjukdom har vi valt att studera proteiner som är involverade i dessa sjukdomar. Vi har arbetat med proteiner som finns i utrymmet utanför cellerna, dvs. den extracellulära matrisen. Cellerna formar sin egen närliggande miljö genom att utsöndra diverse proteiner. Dessa proteiner bildar sedan ett komplext nätverk med varandraThe cells of higher organisms exist in a complex protein network, the extracellular matrix (ECM), which has a wide variety of different components such as glycoproteins, proteoglycans and carbohydrates. As well as being the physical scaffold on which the cells are dependent for their positioning and mobility, the ECM exercises control over the cells, and changes in the matrix will affect the adhes

The fate of phosphate in the environment is governed by reactions at particle surfaces. These adsorption and desorption reactions display biphasic kinetics involving an initial rapid reaction followed by a substantially slower one extending over long time periods. In this study we have investigated the molecular mechanisms of desorption kinetics of phosphate from ferrihydrite and goethite nanopart

Aims: Climate change is known to drive both the reshuffling of whole assemblages and range shifts of individual species. Less is known about how local colonizations and extinctions of individual species contribute to changes at the community level. Our aim was to estimate the contribution of individual species to a change in community composition attributed to climate change and to relate these sp

Microorganisms have unique biochemical mechanisms to inhibit the growth or kill other microorganisms in the same environment. Bacterial threat agents (BTA) are more effective than conventional weapons because of these characteristics, therefore, the development and production of biological weapons are still relevant. Early warning signals need to be obtained for fast and accurate detection of BTA

Pool boiling is an effective heat dissipation approach in electronic cooling, battery thermal management, etc. This study used the electrochemical deposition method to fabricate one smooth nickel specimen (named Ni-smooth) and three specimens with a porous nickel-stacked structure. The three porous specimens were created with deposition current densities of 0.5 A·cm–2 (named Ni-0.5), 2.0 A·cm–2 (n

AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection aga

BACKGROUND: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.METHODS AND RESULTS: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H

Invertebrate embryos have relatively low fossilization potential; however, when preserved, they can offer crucial insights into the evolutionary developmental biology of extinct animals. Here we report new exceptionally preserved fossil embryos from the early Fortunian (early Cambrian) of China, which are assigned to two new taxa, Saccus xixiangensis gen. et sp. nov. and Saccus necopinus gen. et s

OBJECTIVE: This study evaluated the effects of a 6-week osteoarthritis (OA) exercise and education intervention on metabolic health markers, including blood pressure (BP), glycated haemoglobin (HbA1c), high-density lipoprotein (HDL), cholesterol levels and weight in individuals with both OA and diabetes.METHODS: Data originated from the Swedish Osteoarthritis and Diabetes cohort, which is composed

This thesis offers a cultural analysis of climate change, modernisation and sustainable development in the pastoral landscape of Baringo, Northern Kenya. For the majority of the pastoralists living there, life is defined by crippling poverty, ethnic violence and an increasingly erratic and unpredictable climate. In response, a growing number of people have moved away from the traditional reliance

The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in GSIS using isolated murine islets. Additionally, the significance of extracellular NO on GSIS was studied. Islets incubated at basal glucose showed modes

Landscape-scale land use is important in driving species communities and interactions. However, despite increasing concerns regarding the ecological consequences of insect declines, our understanding of how the relative proportions of different land cover types influence insect herbivory in species-rich semi-natural habitats remains limited. This study assessed leaf, stem, and flower herbivory acr

High latitude mires are key ecosystems in the context of climate change since they store large amounts of carbon while constituting an important natural source of methane (CH4). However, while a growing number of studies have investigated methane fluxes (FCH4) at the plot- (~1 m2) and ecosystem-scale (~0.1–0.5 km2) across the boreal biome, variations of FCH4 magnitudes and drivers at the mesoscale

BACKGROUND: Mental health service users often experience difficulties interpreting and regulating sensory stimuli resulting in increased anxiety, decreased abilities to engage in activities and a hampered recovery process. However, there are limited studies on the implementation of such recovery-oriented interventions targeting sensory difficulties via sensory modulation techniques. Therefore, the

Water management tackles complexities within the interconnected social, political, economic and ecological systems across scales, while aiming to meet the needs of multiple stakeholders dependent on water. Many tensions and unsolved issues persist in water management regarding socio-political power structures, spatial scale, and relations between stakeholders who have different perceptions on prob

The current conflict in Syria has resulted in a major refugee disaster. The lack of legal refugee routes to Europe is forcing refugees to hire smugglers to escape war in their homeland. They are often forced to pay large sums of money for the hazardous journey across the Mediterranean Sea and further through Europe. These journeys are often far stretched and not many are successful. Due to the war

Questions: Earth observation is an important tool in biological monitoring. Previous studies have shown that variation in grassland canopy reflectance can explain gradients in plant community composition. However, there is a need for methods that allow the interpretation of the overall spectral signal of complex grassland vegetation in terms of existing knowledge about individual species' habitat

UNLABELLED: Affibody molecules are small (7 kDa) nonimmunoglobulin scaffold proteins with favorable tumor-targeting properties. Studies concerning the influence of chelators on biodistribution of (99m)Tc-labeled Affibody molecules demonstrated that the variant with a C-terminal glycyl-glycyl-glycyl-cysteine peptide-based chelator (designated ZHER2:V2) has the best biodistribution profile in vivo a

PM för studenter och handledare av examensarbeten i Miljövetenskap PM för studenter och handledare av examensarbeten i Miljövetenskap Nedan följer ett PM för genomförande av examensarbeten i miljövetenskap vid Lunds universitet. Examensarbete i miljövetenskap är obligatoriskt för kandidat- (15 hp examensarbete) magister och masterexamen (15+15 eller 30 hp) i miljövetenskap eller miljö- och hälsosk

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/pmstudent_och_handledare.pdf - 2026-07-17

PEDI3945064 1..11 Research Article Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort Carin Andrén Aronsson ,1 Roy Tamura,2 Kendra Vehik,2 Ulla Uusitalo,2 Jimin Yang,2 Michael J. Haller,3 Jorma Toppari,4,5 William Hagopian,6 Richard A. McIndoe,7 MarianJ.Rewers,8Anette-G.Ziegler,9BeenaAkolkar,10 J

https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-11/156%20_MP148_Aronsson_PedDiab_2023_0.pdf - 2026-07-17