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TGFα is a member of the epidermal growth factor (EGF) family and is one of the ligands for the EGF- receptor. The precursor of TGFα, pro-TGFα, is a transmembrane protein. The aim of this project has been to establish a model for studies of pro-TGFα effects on EGF receptor signalling, in particular through Gab1, a docking protein involved in PI3K/Akt signalling pathway. The experiments in this thes
Microsoft Word - Dokument3 Experimental Infrastructure and HR platforms FACS / Cellomics Research Engineer Salary (100%), FACS, Cellomics, Plate Runner 961 834 Service contract FACS 185 000 Rent Cellomics, FACS, Biomolecular imager (B1135a, B1133a, B1133b, B1155a) 408 339 FACS / Cellomics Sum 1 555 173 Gene therapy/Viral Vectors AAV platform, Salary (RE 50% + rent) 510 500 Lenti & Bact platform, S
https://www.multipark.lu.se/sites/multipark.lu.se/files/2021-09/Current%20MultiPark%20budget%202021%20.pdf - 2026-10-04
Background: Atopic dermatitis (AD) is characterized by an increased susceptibility to skin infections. Staphylococcus aureus is reported to dominate in AD lesions and reports have revealed the presence of staphylococcal biofilms. These infections contribute to aggravation of the eczema. Sodium hypochlorite is known to reduce bacterial load of skin lesions, as well as disease severity, in patients
Desirable laser applications in dermatology Bertil Persson MD, senior consultant Department of Dermatology SUS Lund Skane university Hospital/Lund University Current laser applications in Dermatology Vascular anomalies and cosmetic applications Tumour diagnostic and treatment applications • CO2-lasers • YAG-lasers • PDL-lasers • Erbium-lasers • Argon-lasers • CO2-lasers • Photodynamic diagnostics
https://www.mlc.lu.se/fileadmin/mlc/Minnesanteckningar/Laserapplikationer_foer_dermatologin_Bertil_Persson.pdf - 2026-10-03
Research School Advisory Board | ADMIRE Search ADMIRE Lund University Home About Courses Activities Members Tools Links Home > About > Research School Advisory Board Denna sida på svenska This page in English Research School Advisory Board Pablo Villanueva Perez Coordinator Phone: +46 46 222 38 13 E-mail: pablo.villanueva@sljus.lu.se Microscopy Experience: XRM (X-ray microscopy) Maria Messing
https://www.admire.lu.se/about/research_school_advisory_board/ - 2026-10-04
α-Synuclein is an intrinsically disordered protein implied in still not-well-known healthy function and also found as the main component of aggregates in Lewy bodies and Lewy neurites, hallmarks of the Parkinson’s disease. In both of cases, the interaction with lipid membranes is crucial. In this study we propose the investigation of the interaction between α-Synuclein and model systems made of DO
The bioactivity, biological fate and cytotoxicity of nanomaterials when they come into contact with living organisms are determined by their interaction with biomacromolecules and biological barriers. In this context, the role of symmetry/shape anisotropy of both the nanomaterials and biological interfaces in their mutual interaction, is a relatively unaddressed issue. Here, we study the interacti
Severe soft tissue infections, such as necrotizing fasciitis and severe cellulitis, caused by group A streptococcus (GAS) are rapidly progressing life-threatening infections characterized by massive bacterial load in the tissue even late after onset of infection. Antimicrobial peptides are important components of the innate host defence and cathelicidins have been shown to protect against murine n
Aphanomyces rot root is an important disease in sugar beet, leading to significant harvest losses and a decrease in sugar content in affected fields. The disease is caused by the oomycete Aphanomyces cochlioides and affects the roots as either an early or late infection. To control the disease, it is crucial to incorporate resistance into cultivars. However, the genetic background to resistance is
Sialylations are post-translational modifications of proteins and lipids that play important roles in many cellular events, including cell-cell interactions, proliferation, and migration. Tumor cells express high levels of sialic acid (SA), which are often associated with the increased invasive potential in clinical tumors, correlating with poor prognosis. To overcome the lack of natural SA-recept
The increase of plasma levels of high-density lipoproteins and Apolipoprotein A-I (ApoA-I), its main protein component, has been shown to have a positive action on glucose disposal in type 2 diabetic patients. The current study investigates the unexplored function of ApoA-I to prime beta cells for improved insulin secretion. INS-1E rat clonal beta cells as well as isolated murine islets were used
Aim: The role of islet nitric oxide (NO) production in insulin releasing mechanisms is unclear. We examined whether the beneficial effects of the imidazoline derivative RX 871024 (RX) on beta-cell function might be related to perturbations of islet NO production. Methods: Experiments were performed with isolated islets or intact mice challenged with glucose or carbachol with or without RX treatmen
Candida albicans, an important pathogenic yeast, activates all three pathways of the complement system. To understand how this yeast evades the effects of the activated system, we have analyzed the binding of the classical pathway inhibitor C4b-binding protein (C4BP) by C. albicans. Purified native as well as recombinant C4BP bound dose dependently to the yeast and hyphal forms, as shown by multip
We have recently shown that 17β-estradiol (E2) and the synthetic G protein-coupled receptor 30 (GPR30) ligand G-1 have antiapoptotic actions in mouse pancreatic islets, raising the prospect that they might exert beneficial effects also in human islets. The objective of the present study was to identify the expression of GPR30 in human islets and clarify the role of GPR30 in islet hormone secretion
The purpose of this study was to examine some fundamental aspects of the particle formation during spray drying, related to particle size and density. Particles were prepared in a laboratory spray dryer from carbohydrates with different solubility and crystallization propensity, such as lactose, mannitol, and sucrose/dextran 4:1. The feed concentrations ranged from 1% w/w to saturated and the size
Background: Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium. Syndecan 3 seems to prevail in the human uterus among heparan sulphate proteoglycans, showing the most significant increase during labour. The aims of the present study were to investigate syndecan 3 and connexin 43
Oil-in-water emulsions have been stabilized by functionalized cellulose nanofibrils bearing either a negative (oxidized cellulose nanofibrils, OCNF) or a positive (cationic cellulose nanofibrils, CCNF) surface charge. The size of the droplets was measured by laser diffraction, while the structure of the shell of the Pickering emulsion droplets was probed using small-angle neutron scattering (SANS)
