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The possible implication of the gasotransmitters NO and CO for the development of diabetes remains unresolved. Our previous investigations in rodents suggested NO being inhibitory, and CO stimulatory, to glucose-stimulated insulin secretion (GSIS). Here we studied the possible role of these gasotransmitters in both murine and human type 2 diabetes (T2D) by mapping the expression pattern of neural
Moraxella catarrhalisis a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step inM. catarrhaliscolonization is adherence to the mucosa, epithelial cells, and extracellular matrix (ECM). The objective of this study was to evaluate the role ofM. catarrhalisint
BACKGROUND: The presence of an apolipoprotein E4 (ApoE4) genotype is the major genetic risk factor for Alzheimer's disease (AD). Astrocytes are the main source of ApoE in the brain, however ApoE can also be produced by neurons and microglia. ApoE plays a role in many cell types and processes related to AD, however, it remains unclear which mechanism(s) and cellular source of ApoE are most critical
Background: Absence seizures (petit mal seizures) are characterized by a brief loss of consciousness without loss of postural tone. The disease is diagnosed by an electroencephalogram (EEG) showing spike–wave discharges (SWD) caused by hypersynchronous thalamocortical (TC) oscillations. There has been an explosion of research highlighting the role of astrocytes in supporting and modulating neurona
Selective degradation of mitochondria by autophagy (mitophagy) is thought to play an important role in mitochondrial quality control, but our understanding of which conditions induce mitophagy in plants is limited. Here, we developed novel reporter lines to monitor mitophagy in plants and surveyed the rate of mitophagy under a wide range of stresses and developmental conditions. Especially carbon
Popular Abstract in Swedish Regleringen av esofagus och den nedre esofagussfinkterns motilitet har rönt intresse på grund av dess betydelse vid vissa sjukdoms-tillstånd såsom gastroesofageal reflux och akalasi. Den nedre esofagussfinktern har vidare använts som modell för farmakologiska och fysiologiska studier av viss typ av autonom neurotransmission, s k icke-adrenerg, icke-kolinerg (NANC) neuroThe inhibitory neuromuscular control of the human and cat lower oesophagus was investigated by morphological, functional, and biochemical methods. A supply of nerve fibres and myenteric cell bodies, containing nitric oxide synthase (NOS), haem oxygenase (HO)-2, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase activating peptide (PACAP) was observed. The highest density of nerve
Budget 2019 Budget 2020 Budget 2021 Budget 2022 General Budget MultiPark EMV OH 23,5% EMV OH 23,5%? EMV OH 23,5%? EMV OH 23,5%? Income 27 891 000 27 891 000 Balance from previous year (estimated) 6 374 116 5 892 671 7 315 367 4 115 749 Rent subvention 191 389 191 389 Income Total 34 456 505 33 975 060 7 315 367 4 115 749 Management Coordinators (2 persons 50%) 957 433 975 539 Admin personnel (1 pe
https://www.multipark.lu.se/sites/multipark.lu.se/files/2018-12-13.pdf - 2026-10-03
1 LBIC PM 88 2017-12-20 Valid from 2018-01-01 until further notice, maximum validity until 2019-12-31. For general information about LBIC, please see: http://www.med.lu.se/bioimaging_center (A) Project planning Projects start with a meeting between the researcher and LBIC staff representing the platform requested. The main goal of this first meeting is to inform each other on the preclinical imagi
https://www.lbic.lu.se/sites/lbic.lu.se/files/pm_88_lbic_preclin_user_policy_171220.pdf - 2026-10-03
We have previously shown that protein kinase Cepsilon (PKCepsilon) induces neurite outgrowth via its regulatory domain and independently of its kinase activity. This study aimed at identifying mechanisms regulating PKCepsilon-mediated neurite induction. We show an increased association of PKCepsilon to the cytoskeleton during neuronal differentiation. Furthermore, neurite induction by overexpressi
Eukaryotic cells employ the RNA interference (RNAi) machinery in the cytosol to downregulate gene expression. Short 21-nucleotide microRNAs (miRNAs) associate with the so-called RNA induced silencing complex (RISC) and hybridize with the target gene’s mRNA, preventing it from being translated into protein. Employing the RNAi machinery with synthetic small interfering RNAs (siRNAs) that mimics the
Popular science summary The effect of glucose and incretin proteins on insulin secretion and OPN production Insulin secretion is a sensitive cellular process with ramifications in diabetes mellitus development. Diabetes mellitus is characterized by hyperglycemia, a chronic condition defined by high levels of circulating glucose. Insulin hormone is the primary regulator of glucose absorption from
Popular Abstract in Swedish Kväveoxid (NO) och framför allt kolmonoxid (CO) tillhör de giftigaste gaserna man känner till. Vem har inte läst i kriminalromaner om hur människor stängts in i garage och gasats ihjäl med kolmonoxid från arbetande bilmotorers avgasutsläpp. Under det senaste årtiondet har man kunnat visa att dessa gaser i själva verket bildas i vår egen kropp och att de utgör signalmoleDuring the last decade it has been shown that nitric oxide (NO) and carbon monoxide (CO) are produced in our own body, and that they constitute a novel class of messenger molecules. In 1992 a constitutive NO-producing NO-synthase (cNOS) was found in the islets of Langerhans, and in 1997 we could show for the first time that the islets also contained a CO-producing constitutive heme oxygenase (HO-2
IGF-1 is an essential regulator of fetal growth and brain development. Preterm birth in the human is followed by a rapid decrease in serum levels of IGF-1 and decreased levels of IGF-1 have been associated with development of severemorbidity. A recent clinical trial indicated that supplementation with IGF-1 prevented development of severe intraventricular hemorrhage (IVH) in extremely preterm infa
The objective of the present study was to map the mechanism whereby G protein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor (GPER), stimulates extracellular signal-regulated kinase (ERK)1/2 signaling. GPR30 plays important roles in cancer and cardiometabolic regulation. We showed recently that GPR30 forms a plasma membrane complex through its C-terminal type I PSD-95
Toll-interleukin-1 (Toll-IL-1) receptor signaling may play a key role in the development of airway hyperreactivity (AHR) and chronic airway inflammatory diseases such as asthma. Previously, we have demonstrated that pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), induce AHR. However, the underlying intracellular signaling mechanisms that lead t
Aims/hypothesis: Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger NOD-like receptor pyrin domain containing-3 (NLRP3) inflammasome activation. C4b-binding protein (C4BP), present in serum, binds to IAPP and affect
10 min about SUPER‐resolution microscopy Ivan Scheblykin, Kemisk Fysik, LU Nobel Prize in Chemistry 2014 Prof. Ivan Scheblykin, Single Molecule Spectroscopy, Kemisk Fysik “Chemistry independent” Trying to get more information about the object using optical tricks and special analysis Resolution improvement up to 2 times “Chemistry dependent”. Single object emission/excitation Special labeling + t
https://www.mlc.lu.se/fileadmin/mlc/Minnesanteckningar/Super-resolution_Intro_Ivan_Scheblykin.pdf - 2026-10-01
Epilepsy is a severe chronic neurological disorder characterized by recurrent spontaneous seizures. Excitatory/inhibitory (E/I) imbalance, neuronal loss, brain inflammation, and altered adult neurogenesis are some of the characteristic hallmarks of epilepsy. Seizures increase the production of new hippocampal neurons but their function in the epileptic brain is still not fully understood. Elucidat
Membrane cleaning is an integrated part of the daily membrane plant operation in the food and biotech industry. However, the impact of membrane cleaning on the plant operations and economics are often neglected parameters in the development of new applications despite the fact that the cost for membrane cleaning is a dominating membrane operating expenditure apart from electricity. The aim of this
The exact cellular functions of cystatins are still unknown, and the molecular mechanism leading to their internalization into cells is not yet fully understood. Commonly the cystatins are known to inhibit human lysosomal cysteine proteases (cysteine cathepsins) and it is supposed that this is their primary physiological role. The cystatins are traditionally believed to mediate regulation of cyste
