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We offer courses at a PhD level as a part of your postgraduate studies. The Department of Biology offers courses at a postgraduate level to both internal and external PhD students. Contact the person responsible for the course to get information about prerequisites and how to apply. Evolutionary processes This graduate course in evolutionary biology emphasises the various evolutionary processes ra

https://www.biology.lu.se/phd-studies/phd-courses - 2026-10-05

Budget follow-up 2019_excel Budget 2019 UTFALL 2019.12.31 INKL OH Diff vs budget General Budget MultiPark EMV OH 23,5% Income 28 842 000 28 842 000 0 Balance from previous year (estimated) 10 975 226 10 273 062 702 164 Rent subvention 246 202 253 330 7 128 Income Total 40 063 428 39 368 392 -695 036 40 063 428 Management Coordinators (2 persons 50%) 951 755 951 865 -110 Admin personnel (1 person,

https://www.multipark.lu.se/sites/multipark.lu.se/files/2021-09/Budget%20follow-up%202019.pdf - 2026-10-06

Nanoscience_Colloquium_2018_01_21_Ed_Boyden_lores For full program of NanoScience Colloquia see: http://www.nano.lu.se/news-and-events/nanoscience-colloquia NNAANNOOSSCCIIEENNCCEE CCOOLLLLOOQQUUIIUUMM Prof. Edward S. Boyden Monday January 21st, 2019 at 15:15, in Rydbergssalen, Fysicum Nanotechnology for Mapping, Controlling, and Building Brain Circuits and Other Complex Systems Y. Eva Tan Professo

https://www.nano.lu.se/sites/nano.lu.se/files/nanoscience_colloquium_2018_01_21_ed_boyden_lores.pdf - 2026-10-06

Precision cut lung slices (PCLS) are complex three-dimensional (3-D) lung tissue models, which preserve the native microenvironment, including cell diversity and cell-matrix interactions. They are an innovative ex vivo platform that allows studying disease as well as the effects of therapeutic agents or regulatory molecules [e.g., microRNA (miRNA)]. The aim of our study was to develop a protocol t

Cell culturing is most commonly performed in conventional 96-well plates where cells are grown in a monolayer, on two-dimensional (2D) surfaces. However, a tumor grows in three dimensions (3D) in the human body and exhibits complex features that cannot be translated onto a 2D system. Likewise, an anti-cancer drug that has been pre-clinically tested in a 2D system is likely to fail clinical trials.

Type 2 diabetes is characterized by hyperglycemia and insulin resistance, which leads to increased production of insulin. Together with insulin the hormone peptide islet amyloid polypeptide (IAPP) is secreted, which is thought to be the cause of beta-cell death in later stages of type 2 diabetes. C4b-binding protein (C4BP) has been shown to upregulate IAPP fibrillation, which would lead to more ma

Deficiencies of complement proteins of the classical pathway are strongly associated with the development of autoimmune diseases. Deficiency of Clr has been observed to occur concomitantly with deficiency in Cls and 9 out of 15 reported cases presented systemic lupus erythernatosus (SLE). Here, we describe a family in which all four children are deficient in Cls but only two of them developed SLE.

Abstract Receptor activity-modifying protein 3 (RAMP3) is a single-pass transmembrane protein known to interact with and affect the trafficking of several G-protein-coupled receptors (GPCRs). We sought to determine whether RAMP3 interacts with GPR30, also known as G-protein-coupled estrogen receptor 1. GPR30 is a GPCR that binds estradiol and has important roles in cardiovascular and endocrine phy

The habenula is a phylogenetically conserved brain structure in the epithalamus. It is a major node in the information flow between fronto-limbic brain regions and monoaminergic brainstem nuclei, thus anatomically and functionally ideally positioned to regulate emotional, motivational and cognitive behaviors. Consequently, the habenula may be critically important in the pathophysiology of psychiat

The aim of the present study was to develop an understanding of how wheat plants can be used as a “green factory” by the modulation of genotype (G) and environmental (E) interactions to fine-tune the structure and increase the strength of gluten based materials. Two wheat genotypes (5 + 10 and 2 + 12) were grown under four nitrogen and two temperature regimes to obtain gluten of various characteri

Corrosion is of considerable concern whenever metal is used as construction material. In this study we address whether superhydrophobic coatings could be used as part of an environmentally friendly corrosion-protective system, and specific focus is put on how the wetting regime of a superhydrophobic coating affects corrosion inhibition. Superhydrophobic alkyl ketene dimer (AKD) wax coatings were p

Preclinical trials of cancer drugs in animal models are important for drug development. The Rip1Tag2 (RT2) transgenic mouse, a model of pancreatic neuroendocrine tumours (PNET), has provided immense knowledge about PNET biology, although tumour progression occurs in a location inaccessible for real-time monitoring. To overcome this hurdle we have developed a novel platform for intravital 3D imagin

Proteolytic cleavage of thrombin generates C-terminal host defense peptides exerting multiple immunomodulatory effects in response to bacterial stimuli. Previously, we reported that thrombin-derived C-terminal peptides (TCPs) are internalized in monocytes and macrophages in a time- and temperature-dependent manner. In this study, we investigated which endocytosis pathways are responsible for the i

HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study investigated if these diverse effects of HAMLET might be caused, in part, by a direct effect on the ATP synthase and a resulting reduction in cellular ATP levels. A dose-dependent reduc

The important issue addressed by the studies presented here is the mechanism of neutrophil-mediated damage to endothelial and epithelial cells during inflammation. Binding of neutrophil-released granule proteins to endothelial cells may be involved in vascular damage in patients with inflammatory vascular diseases. We have determined whether granule proteins proteinase 3(PR3) and/or myeloperoxidas

A better understanding of skeletal muscle lipid metabolism is needed to identify the molecular mechanisms relating intramuscular triglyceride (IMTG) to muscle metabolism and insulin sensitivity. An increasing number of proteins have been reported to be associated with intracellular triglyceride (TG), among them the PAT family members: perilipin, ADRP ( for adipocyte differentiation-related protein

PRELP is a heparin-binding leucine-rich repeat protein in connective tissue extracellular matrix. In search of natural ligands and biological functions of this molecule, we found that PRELP binds the basement membrane heparan sulfate proteoglycan perlecan. Also recombinant perlecan domains I and V carrying heparan sulfate bound PRELP, whereas other domains without glycosaminoglycan substitution di