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A partition study with peptides and recombinant proteins in poly(ethylene glycol)4000-potassium phosphate aqueous two-phase systems has been performed. The aim was to study to what extent the insertion of charged residues could affect protein partition in addition to the already observed effects of tryptophan residues. The model proteins used are based on a staphylococcal protein A derivative, Z,
The blood concentrations of lidocaine and its main active metabolites, methylethylglycinexylidide (MEGX) and glycinexylidide (GX), were measured in 24 newborn infants during anticonvulsive treatment with an iv infusion of lidocaine. After a bolus dose of 1.5-2.2 mg/kg and continuous infusion of lidocaine (4.7-6.3 mg/kg/h) there was accumulation of the drug and MEGX within 24 h. After termination o
This study characterizes the high-fat diet-fed mouse as a model for impaired glucose tolerance (IGT) and type 2 diabetes. Female C57BL/6J mice were fed a high-fat diet (58% energy by fat) or a normal diet (11% fat). Body weight was higher in mice fed the high-fat diet already after the first week, due to higher dietary intake in combination with lower metabolic efficiency. Circulating glucose incr
In boron neutron capture therapy (BNCT) the absorbed dose to the tumor cells and healthy tissues depends critically on the boron uptake. Pronounced individual variations in the uptake patterns have been observed for two boron compounds currently used in clinical trials. This implies a high uncertainty in the determination of the boron dose component. Ln the present work a technique known as prompt
Symptomatic portal hypertension (PH), is often treated by transjugular intrahepatic portosystemic shunt (TIPS). Patients with PH, caused by prehepatic portal vein occlusion, require recanalization with stent or stent-graft often followed by additional TIPS. Stent-grafts used for TIPS, may occlude the outflow from the adjacent hepatic vein, potentially disturbing the circulation through the adjoini
A method for analysing the influence of profile errors upon load-sharing capabilities and mesh stiffness of spur gears is proposed. The analysis is based upon a static, two-dimensional finite element approach. The contacts between mating gear teeth are identified in the deformed state, and the nodal point density permits contact pressure distribution emulation for moderate to high load levels. In
The N 1s --> pi* photoabsorption profile of N-2 is quantitatively analysed. New spectroscopical constants for the N 1s(-1) pi* core-excited state are determined from NEXAFS spectra and compared to previously published data. The accuracy of the new spectroscopical constants is discussed and error bars are given for the present data analysis. The goodness of the new spectroscopical constants is demo
Background The national hip registers of the Nordic countries provide an opportunity to compare age- and sex-standardized annual incidence of primary total hip replacement (THR) and types of implants used for primary hip osteoarthritis (OA) in Denmark, Finland, Iceland, Norway and Sweden. Methods The data on THR were from the national total hip replacement registries, and population data were from
A new binaphthalene molecule with two spiropyran units used for chiral molecular switches and logic gates was synthesized and chaxacterized.(12) In this paper, charge and energy transfer in binaphthalene molecule with two spiropyran units are theoretically investigated with quantum chemistry method, as well as 2D and 3D real space analysis methods, since molecule construction with photoinduced ele
The SYT-SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma, but the underlying molecular mechanisms are still poorly understood. Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells. Antisense oligonucleotides to SYT-SSX mRNA rapidly and drastically decreased cyclin D1 and subsequently inhibited cell growt
Background The design of the Exeter stem may facilitate distal migration, but radiostereometric analysis (RSA) studies have been limited to 2 years of follow-up. Patients and methods We followed migration of the Exeter femoral stems in 22 primary hip arthroplasties for 5 years with RSA. Results All stems migrated distally and the median migration at 2 years was 1.34 mm, while at 5 years it was 1
Complete mitochondrial DNA (mtDNA) control regions (CR) were sequenced and analysed in order to investigate wild sheep taxonomy and the origin of domestic sheep (Ovis aries). The dataset for phylogenetic analyses includes 63 unique CR sequences from wild sheep of the mouflon (O. musimon, O. orientalis), urial (O. vignei), argali (O. ammon) and bighorn (O. canadensis) groups, and from domestic shee
Currently, in real-time PCR, one often has to choose between using a sequence-specific probe and a nonspecific double-stranded DNA (dsDNA) binding dye for the detection of amplified DNA products. The sequence-specific probe has tire advantage that it only detects the targeted product, while the nonspecific dye has the advantage that melting curve analysis can be performed after completed amplifcat
The impact of warmer climate on melt and evaporation was studied for tainted, snowfed and glacierfed basins located in the western Himalayan region. Hydrological processes were simulated under current climatic conditions using a conceptual hydrological model, which accounts for the rainfall-runoff, evaporation losses, snow and glacier melt. After simulations of daily observed strearnflow (R-2 = 0.
Background/Aim: In occupational therapy research and in clinical practice there is a need for valid, reliable and easily administered measures. For research and screening purposes, the Satisfaction with Daily Occupations (SDO) instrument was developed. It addresses work, leisure, domestic tasks and self-care and generates a satisfaction and an activity level score. This study investigated its cons
The drought of 2003 was exceptionally severe in many regions of Europe, both in duration and in intensity. In some areas, especially in Germany and France, it was the strongest drought for the last 50 years, lasting for more than 6 months. We used continuous carbon and water flux measurements at 12 European monitoring sites covering various forest ecosystem types and a large climatic range in ord
