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OBJECTIVES: The soluble epoxide hydrolase (gene name EPHX2) is responsible for metabolism of 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. There are several functional polymorphisms in the EPHX2 gene: two of them, the K55R and R287Q, showing an altered metabolic activity in vitro, were associated with coronary heart disease and ischemic stroke in prev
BACKGROUND: Several instruments have been developed for measuring asthma control, but there is still a need to provide a structure for primary care asthma reviews. AIMS: The Active Life with Asthma (ALMA) tool was developed with the aim of structuring patient visits and assessing asthma treatment in primary care. The ability of ALMA to map out the care of asthma patients was evaluated and validate
Aims: The present study aimed at testing the hypothesis that atrial fibrillatory rate (AFR) is predictive of sinus rhythm maintenance after electrical cardioversion. Methods and results: The study comprised 32 patients admitted for cardioversion of atrial fibrillation of short duration (mean duration 3.8 ± 7.7 days). AFR was estimated using frequency power spectrum analysis of QRST-cancelled ECG.
Objectives: In India, cervical cancer is the most common cancer among women and makes up for up to 29% of all registered cancer in females. Cancer-related pain is one of the major distressing symptoms for all cancer patients. Pain is characterised as somatic or neuropathic, and the total pain experience is often mixed. Conventional opioids are the backbone of analgesic treatment but are most often
AIM: Breath-holding spells (BHS) are common in children, but evidence-based clinical guidelines are lacking. We investigated a large population-based cohort of BHS patients, to propose a refined description of typical BHS and guidelines for its management.METHODS: In a cross-sectional retrospective study, patients diagnosed with BHS in Southern Sweden 2004-2018 were recruited. Disease characterist
Cell replacement therapies for Parkinson's disease (PD) based on transplantation of pluripotent stem cell-derived dopaminergic neurons are now entering clinical trials. Here, we present quality, safety, and efficacy data supporting the first-in-human STEM-PD phase I/IIa clinical trial along with the trial design. The STEM-PD product was manufactured under GMP and quality tested in vitro and in viv
Background: Patients with oesophageal and gastric cancer face a poor prognosis and multiple symptoms and problems that negatively affect their quality of life. In view of the prognosis and extensive illness burden, an early palliative care approach is of importance.Aim: The overall aim of this thesis was to describe and compare symptoms, problems and care needs in relation to the initial treatment
Streptococcus pneumoniae (pneumococcus) is an asymptomatic colonizer of the nasopharynx in most individuals but can progress to a pulmonary and systemic pathogen upon influenza A virus (IAV) infection. Advanced age enhances host susceptibility to secondary pneumococcal pneumonia and is associated with worsened disease outcomes. The host factors driving those processes are not well defined, in part
Urbanisation drives overall declines in insect pollinators. Although urban green spaces can provide suitable habitat for pollinators much remains to be learned about how urban landscapes either promote or negatively impact pollinators. We investigated how backyard design, local (100 m) and landscape (500 m) scale vegetation cover and human population density were associated with non-eusocial nativ
With the urgent demand for ultralow-temperature refrigerators worldwide, the operation reliability and stability of the refrigeration system becomes greatly crucial. In this study, a -80 oC ultralow-temperature cascade refrigeration system (CRS) is developed. From aspects of global warming potential (GWP) and ozone depletion potential (ODP), the environmentally friendly refrigerants R290 and R170
Frailty refers to the lack of resilience and a reduction in a person’s ability to recover following a health problem, and it is increasingly becoming a challenging aspect of ageing populations.Many older adults are exposed to polypharmacy; i.e., they continue to be on medications without timely re-evaluation. Medication reviews have proven successful in managing polypharmacy in the general populat
The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.The aim of this article is to articulate how legal processes, that produce assumptions about social realities which subsequently shape relations of inequality and oppression, may be explored using a critical legal cartographic approach. Critical cartography points to the duality of representation and construction that is innate to cartography, i.e. when portraying reality, maps are also making it.
Cardiometabolic diseases are the leading preventable causes of death in most geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic diseases vary greatly worldwide, as do the resources and strategies needed to prevent and treat them. Therefore, there is no single solution and health care should be optimised, if not to the individual (ie, personalised health care), the
Alla barn har rätt till en grundläggande utbildning. Det är en mänsklig rät-tighet som stadgas i exempelvis barnkonventionen. Forskning visar att sko-lan är en bra skyddsfaktor, en fungerande skolgång minskar risken att hamna i ogynnsamma förhållanden, exempelvis kriminalitet. Barn som är placerade utanför hemmet är en grupp som löper större risk att hamna i ogynnsamma förhållanden, samtidigt som Every child has the right to a primary education. This is a human right stat-ed in documents such as the Convention on the Rights of the Child. Re-search shows that school is a significant protective factor; a functioning school experience reduces the risk of ending up in harmful environments, such as criminality. Children placed outside their homes are a group which are at greater risk of ending
Society is undergoing a great transformation with regard to the climate crisis, where electrification plays a crucial role in decarbonizing. To meet the future energy demand, improving power grid utilization is essential. This thesis develops standardized methods to evaluate and identify key parameters in terms of impact and branch loading, and to determine the probability of load flow scenarios u
Today there are limited theories that consider the research subject relationship creation as a contributing factor to a company’s brand loyalty within an organizational marketing context. The purpose of this thesis is to contribute with knowledge about organizational relationship creation between distributors and retailers, and how these relationships are constructed through communication efforts.
För ca 13 000 år sedan bildades ett skarpt avgränsat mörkare sedimentlager i Barsebäcks mosse, då en sjö, idag ett kärr, i sydvästra Skåne. Detta ”mystiska lager” skiljer sig markant från omgivande lager. Vid tidigare studier samt vid fältkurser med studenter från Lunds universitet har detta mystiska lager dykt upp på några meters djup i borrkärnor. För att lösa mysteriet med hur ”det mystiska lagSediment cores from Barsebäcks mosse, an overgrown lake in southwestern Sweden, display a mysterious sediment layer at a few meters depth. The enigmatic dark-coloured layer is in clear contrast to surrounding light coloured calcareous sediments. A 14C analysis provides an age of 12,760-13,075 cal. yr BP. The dating puts the depositional time to the end of the Late-glacial Allerød warm period. This
This special issue explores the extraordinary luminescence properties of metal halide perovskites. Metal halide perovskites have emerged at the forefront of next-generation, thin-film semiconductors for photovoltaic and light-emitting applications. These materials exhibit remarkable optoelectronic properties such as long charge carrier diffusion lengths and high radiative emission efficiencies, wh
