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Background: The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with information on functional protein-protein interactions to elucidate risk independent of LD and to place the genetic association into a functional
In recent years, the mutational status of the KRAS oncogene has become incorporated into standard medical care as a predictive marker for therapeutic decisions related to patients with metastasized colorectal cancer. This is necessary, because these patients benefit from epidermal growth factor receptor (EGFR)-targeted therapy with increased progression-free survival only if the tumor does not car
The World Health Organization has a standardized tool to assess surgical capacity in low- and middle-income countries (LMICs), but it is often resource- and time-intensive. There currently exists no simple, evidence-based measure of surgical capacity in these settings. The proportion of cesarean deliveries in regard to the total operations (C/O ratio) has been suggested as a way to assess quickly
We study the mechanical failure of cemented granular materials (e.g., sandstones) using a constitutive model based on breakage mechanics for grain crushing and damage mechanics for cement fracture. The theoretical aspects of this model are presented in Part I: Tengattini et al. (2014), A thermomechanical constitutive model for cemented granular materials with quantifiable internal variables, Part
Technology foresight studies have become an important tool in identifying realistic ways of reducing the impact of modern energy systems on the climate and the environment. Studies on the future cost development of advanced energy technologies are of special interest. One approach widely adopted for the analysis of future cost is the experience curve approach. The question is, however, how robust
A search is presented for a high-mass Higgs boson in the , , , and decay modes using the ATLAS detector at the CERN Large Hadron Collider. The search uses proton-proton collision data at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 20.3 fb. The results of the search are interpreted in the scenario of a heavy Higgs boson with a width that is small compared with the
Aim: To compare treatment costs with alternative luteinizing hormone-releasing hormone (LHRH) agonist preparations and determine whether a leuprorelin solid implant is associated with potential cost savings. Patients & methods: A hypothetical population of 1000 prostate cancer patients was apportioned between the three most commonly-prescribed LHRH agonist preparations. Differentiated annual c
BACKGROUND AND PURPOSE: We used Riks-Stroke, the Swedish Stroke Register, to explore how thrombolysis has been disseminated in Swedish hospitals since it was approved in 2003. METHODS: All 78 hospitals in Sweden admitting patients with acute stroke participate in Riks-Stroke. Between 2003 and 2008, 72 033 adult patients were hospitalized for acute ischemic stroke. We analyzed thrombolysis use by r
Examensarbetet fokuserar på pentatoniken, som på många sätt är utgångspunkten i afroamerikanskt gitarrspel. Underlaget till denna studie består av intervjuer med professionella musiker och lärare, samt en student. Utgångspunkt tas även i den egna förförståelsen, litteratur, videodokumentärer och CD-skivor. Resultatet av studien visar på stor samstämmighet hos de intervjuade gitarristerna i studienThis dissertation examines one of the basic elements of Afro-American guitar playing, namely pentatonics. The background material consists of interviews with professional guitar players as well as teachers and one student. Literature, recorded audio (CD:s), as well as video and audio documentaries, have also played an important role. The results show a consensus between the majority of the intervi
This thesis addresses the new policy reform for the establishment of newly arrived refugees in Sweden from a welfare policy perspective. The establishment reform aims to further integration of newly arrived refugees into Swedish society by transferring responsibility from local municipalities to the Public Employment Service and by introducing a private actor in the process. In the thesis I analys
In a country as „connected‟ as Sweden, it is hard to imagine a setting in which the Internet does not play a significant role in people‟s everyday lives. The purpose of this thesis is to analyze the use and/or awareness of online health information and services among female immigrants in Malmö, Sweden. The data collected is based on semi-structured interviews with 11 female immigrants of 7 differe
This essay is about education, development and equality. Its main purpose is to examine the relationship between education and development, and how this relationship is understod by the international community, and particularly the UN. The essay also examines the impact education may or may not have on eqality. By analyzing data presented by the UNDP and comparing reports from different organs of
The purpose of this study was to examine the responsibility for children’s right to education. More precisely the aim was to find out who, in the on-going debate, was presented as being responsible of making sure that children, who have the right and obligation to attend school, actually do so. In my study I did a document analysis of two newspapers, one for teachers; Lärarnas tidning, and one for
People, today, use the Internet more and more for everything and there are courses on different aspects of our Internet use: social media, leadership, and networks. However, there is not much said about volunteering online, despite many active online volunteers who work several hours each day. It is relevant to know what inspires and motivates a person to volunteer to keep him or her motivated to
Det här examensarbetet grundar sig på en översättning av en lättläst barnbok, som i sin tur är baserad på en myt från Snorres Edda. Uppsatsen inleds med en källtextanalys, som i viss mån utgår från Lennart Hellspong och Per Ledins (1997) modell, och som grundas på Göte Klingbergs (1977) teorier om bearbetning och översättning av böcker för barn. Därefter följer en kortare diskussion om övervägande
Participation of Civil Society Organisations (CSOs) has been greatly promoted by the European Union (EU) and many CSOs in social policy sphere in particular have increasingly gained their participatory venues and consultative status vis-a-vis EU institutions since the 90’s. However, their expected role to bring even the most marginalised groups’ voice into European policy making process poses a qu
