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Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathwa

Data concerning the importance of family history of venous thromboembolism (VTE) for the risk of recurrent VTE are sparse. The aim of this nationwide study was to determine whether family history of VTE is a risk factor for recurrent hospitalization for unprovoked VTE (deep venous thrombosis of the lower extremities or pulmonary embolism).

Insomnia and short and long sleep durations have all been linked to cardiovascular disease. Male gender and low socioeconomic status are also related to cardiovascular disease, but it is unclear whether these two factors modify the impact of poor sleep on cardiovascular disease incidence.

Background: Assessing and evaluating health care is important, and an abundance of instruments are developed in different languages. Translating existing, validated instruments is demanding and calls for adherence to protocol. Purpose: The purpose of this study was to translate and culturally adapt the FAMCARE-2 scale for use in Sweden. Methods: Traditional back-translation and the decentering sta

To evaluate drug adherence, clinical response and predictors thereof for tocilizumab in patients with RA in routine care based on prospectively collected data from the Swedish biologics register, Anti-Rheumatic Therapies in Sweden.

Syfte: Studiens syfte var att undersöka om det fanns ett samband mellan autistiska drag, autistisk maskering och kön relaterat till upplevda utmattningssymtom hos vuxna. Detta ämne valdes eftersom det finns evidens för att autistiska drag medför konsekvenser för individens välmående samt att dessa konsekvenser ser olika ut beroende på kön. Metod: Data samlades in genom en enkät via SUNET med tre f

There is strong evidence that climate change has a direct impact on humans and extreme temperatures have been linked to negative health impacts and increasing mortality. The heat wave of 2018 caused up to 8.2% more deaths compared to the year before in Sweden, with higher impacts in other parts of the world. The fact that people spent almost 90% of their times indoors makes the indoor environment

In this thesis the inoperability I/O model has been used in a case study to evaluate if it is applicable to Swedish conditions and if it is a suitable approach of describing interdependencies. The inoperability I/O model can, given a perturbation from one or more sectors, estimate the ripple effects measured in terms of industry inoperability and economic losses. The model approximates physical in

BAKGRUND: Effektiv kommunikation och samarbete är en förutsättning för att kunna leverera en vård som är säker för patienten och misstag i kommunikationen mellan personer i vårdkedjan är en vanlig orsak till skador. Ett dilemma i dagens vård är operationsteam med olika yrkesgrupper med ibland otydliga arbetsuppgifter och ansvarsområden, som utgör en stor utmaning för kommunikationen. SYFTE: Att un

Denna uppsats behandlar skydd för utländska investeringar och indirekt expropriation i internationell rätt. En erkänd regel inom internationell rätt föreskriver att egendom som tillhör utländska investerare inte får tillvaratas utan tillräcklig kompensation, oavsett om det är för ett offentligt ändamål eller inte. Medan en bedömning av direkt expropriation anses relativt okomplicerad att företa ha

Although drug abuse (DA) is strongly familial, with important genetic influences, we need to know more about the role of rearing environment in the risk for DA. To address this question, we utilized a high-risk adopted and non-adopted co-sibling control design.

To estimate incremental costs for patients with psoriasis/psoriatic arthritis (PsO/PsA) compared to population-based referents free from PsO/PsA and estimate costs attributable specifically to PsO/PsA.

Rapporten sammanfattar fjärilsinventeringar utförda 2016 inom Biogeografisk uppföljningsom drivs av Naturvårdsverket. I fjällområdet kunde 66 ytor inventeras och sammanlagtnoterades 80 högnordiska blåvingar på 20 ytor och 55 dvärgpärlemorfjärilar på 19 ytor.Inventeringen gav dessvärre inget fynd av fjällsilversmygare detta år. Förekomsten avtajgafjällfly undersöktes på 8 lokaler från Lycksele lapp

Ribs are widely employed in internal cooling passages of turbine blades to enhance heat transfer. From the mathematics, a fractal is an abstract object used to describe naturally occurring objects which exhibits similar properties with increased smaller scales. In a ribbed channel, originating from two sides truncated ribs, fractal truncated ribs are built and the evolving process contains three s

This article aims at describing a logistic approach for prolonged resuscitation efforts in the cath-lab using mechanical chest compressions (MCC) during simultaneous percutaneous coronary intervention (PCI).

High mechanical load in alternating directions with sufficient rest in between the loading periods is one of the best stimuli to enhance bone mass and skeletal structure, both contributing independently to bone strength. The age-frame where skeletal benefits from exercise are largest is in late pre- and early peri-puberty. Recent publications with low level of evidence infer that such skeletal be