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Background: For up to 50% of adolescents experiencing PTSD, the course of their illness is further complicated by co-occurring substance use. Despite this, evidence-based integrated treatment options for adolescents with this comorbidity remain sparse. To address this gap, we are conducting an RCT examining the efficacy of exposure-based therapy for co-occurring PTSD and substance use among adoles
High expression of Junctional Adhesion Molecule-A (JAM-A) has been linked with poor prognosis in several cancers, including breast cancers overexpressing the human epidermal growth factor receptor-2 (HER2). Furthermore, JAM-A expression has been linked with regulating that of HER2, and associated with the development of resistance to HER2-targeted therapies in breast cancer patients. The purpose o
OBJECTIVE: To identify clinical, microscopic, and biochemical characteristics that differentiate cytolytic vaginosis (CV) from vulvovaginal candidiasis (VVC).METHODS: The present cross-sectional study analyzed the vaginal contents of 24 non-pregnant women aged 18 to 42 years who were attended at the Genital Infections Clinic at Centro de Atenção Integral à Saúde da Mulher da Universidade Estadua
Kapitlet lyfter fram frågan om mänskliga rättigheter i utvalda former och hur de påverkar migranters positioner. Ett svenskt exempel illustrerar de utmaningar som migranter står inför i termer av exkludering.
We present a consistent set of calculated energies and E1, M1, E2, M2 radiative transition data for the main n = 3 levels from the 3s23p4, 3p6, 3s3p43d, 3s23p23d2, 3s3p5, 3s23p33d, and 3s3p33d2 configurations for S-like ions from Cr ix to Cu xiv. The fully relativistic multiconfiguration Dirac–Hartree–Fock method implemented in the GRASP2K code is used to perform the present calculations. The exci
The major softwood hemicellulose is galactoglucomannan (GGM), an abundant polysaccharide which constitutes up to 25% of the dry weight of wood, much of which is discarded in current refinery practices. Among the enzymes responsible for the degradation of this hemicellulose are the β-mannanases. Apart from their natural hydrolytic action, some β-mannanases have the ability to catalyse the synthesis
Glucagon is secreted from the pancreatic alpha cells and plays an important role in the maintenance of glucose homeostasis, by interacting with insulin. The plasma glucose levels determine whether glucagon secretion or insulin secretion is activated or inhibited. Despite its relevance, some aspects of glucagon secretion and kinetics remain unclear. To gain insight into this, we aimed to develop a
In the dawning age of autonomous driving, accurate and robust tracking of vehicles is a quintessential part. This is inextricably linked with the problem of Simultaneous Localisation and Mapping (SLAM), in which one tries to determine the position of a vehicle relative to its surroundings without prior knowledge of them. The more you know about the object you wish to track—through sensors or mecha
This transformative study aimed to explore how people who practice BDSM (bondage, discipline, dominance, submission, sadism, masochism) experience therapy; specifically, what sort of therapist responses and qualities they described as problematic and desirable in relation to addressing BDSM in therapy. Semi-structured interviews were conducted with 27 Swedish BDSM practitioners with experiences ofThis transformative study aimed to explore how people who practice BDSM (bondage, discipline, dominance, submission, sadism, masochism) experience therapy; specifically, what sort of therapist responses and qualities they described as problematic and desirable in relation to addressing BDSM in therapy. Semi-structured interviews were conducted with 27 Swedish BDSM practitioners with experiences of
Radionuklidterapi är en form av strålbehandling där sjukdom behandlas genom att ett radioaktivt ämne tillförs till kroppen. Typiskt sett består det tillförda ämnet av två sammankopplade komponenter: Dels en radionuklid (radioaktiv variant av ett viss grundämne) och dels ett läkemedel vars egenskaper gör att det tas upp i det sjuka området. Ofta tillförs det radioaktiva läkemedlet via injektion i eRadionuclide therapy (RNT) is a form of radiotherapy that uses unsealed radioactive sources for the delivery of ionising radiation within a patient's body.Radiation dosimetry is not used routinely in all centres, and the RNT field can benefit from more data on pharmacokinetics and absorbed doses (ADs).Consequently, there is a value in developing and investigating methods that facilitates the acqui
Introduction: Monitoring replacement therapy with standard and extended half-life (EHL) products is challenging, since one-stage assay (OSA) and chromogenic substrate assay (CSA) results may differ significantly. Recent recommendations include local validation of each new product with recovery within 20–30%, depending on activity level. Aim: To validate factor VIII (FVIII) activity for monitoring
Background: Earlier attempts to deliver effective lung doses of surfactant by aerosolization were unsuccessful, mostly because of technical shortcomings. We aimed at quantifying the lung deposition of poractant alfa with a new supraglottic delivery system for surfactant atomization in an experimental neonatal model. Methods: The method involved six sedated 1-day-old piglets lying in the lateral de
The upscaling of perovskite solar cells to modules requires the patterning of the layer stack in individual cells that are monolithically interconnected in series. This interconnection scheme is composed of three lines, P1–P3, which are scribed using a pulsed laser beam. The P3 scribe is intended to isolate the back contact layer of neighboring cells, but is often affected by undesired effects suc
Ex vivo histology remains the gold standard against which MRI biophysical models, e.g. the MR g-ratio which characterises the fraction of a fibre’s diameter that is myelinated, are evaluated. The MR g-ratio model requires a measure of myelin density, for which magnetization transfer saturation (MT) has been used as a biomarker. However, changes occurring post mortem, e.g. autolysis, temperature ch
Background: Inherited pathogenic variants (PVs) in the CDKN2A gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancreatic cancer. In this study, the CDKN2A testing, carried out in Sweden in the years 2015-2020, was evaluated.Materials and methods: Included families had (1) three
The aim of this study was to evaluate the equations for calculating the clothing area factor (fcl) used in the standards based on data sets of clothing ensembles, that are meant to provide thermal comfort over a wide range of climatic conditions from hot summer days to extremely cold winter. Over 10 equations for fcl calculations were selected from the international standards and the literature. A
In 1975, Sweden extended voting rights in local elections to immigrants without Swedish citizenship (resident aliens). In this essay, motives behind the reform are analysed and it is argued that these were based on a wish to speed up the integration of immigrants rather than on normative ideas about the nature of democracy. In fact, the reform was seen as a part of the emerging Swedish integration
