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During development, hematopoietic stem and progenitor cells (HSPCs) arise from specialized endothelial cells by a process termed endothelial-to-hematopoietic transition (EHT). The genetic program driving human HSPC emergence remains largely unknown. We previously reported that the generation of hemogenic precursor cells from mouse fibroblasts recapitulates developmental hematopoiesis. Here, we dem
Background : Colorectal cancer (CRC) is considered one of the most common forms of cancer in the Western world. High intake of red and processed meat is considered to increase CRC development. Objective : This study examined associations between intake of red meats, poultry, and fish and incident CRC, and if weight status modifies the associations. Design : In the Malmö Diet and Cancer Study, diet
Context: The biological mechanism for the association between sleep duration and incident diabetes mellitus (DM) is unclear. Sleep duration and Caspase-8, a marker of apoptotic activity, have both been implicated in beta cell function.Objective: To investigate the associations between sleep duration and plasma Caspase-8, and incident DM, respectively.Design: Prospective cohort study.Setting: The M
Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approa
Cell reprogramming concepts have been classically developed in the fields of developmental and stem cell biology and are currently being explored for regenerative medicine, given its potential to generate desired cell types for replacement therapy. Cell fate can be experimentally reversed or modified by enforced expression of lineage specific transcription factors leading to pluripotency or attain
Lignin is the second most abundant naturally produced organic polymer on earth. Lignin‐modifying enzymes (LMEs) are produced by the white‐rot fungi as products of secondary metabolism, since lignin degradation does not provide any energy to the fungus. The main oxidative enzymes include the peroxidases‐lignin peroxidase (LiP) (diarylpropane: oxygen, hydrogen peroxide oxidoreductase), manganese per
Background: Cadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations between blood cadmium (B-Cd) and 88 potential protein biomarkers of CVD. Methods: B-Cd and 88 plasma proteins were measured in a community-based prospective cohort, the Malmö Diet
A directional crack growth criterion in a compressed elastic perfectly plastic material is considered. The conditions at the crack-tip are evaluated for a straight stationary crack with a small incipient kink. Remote load is a combined hydrostatic pressure and pure shear applied via a boundary layer. Crack surfaces in contact are assumed to develop homogenous Coulomb friction.The crack opening dis
The game plan firms must navigate in the quest of competitive advantage which is changing quickly. More and more firms acknowledge that future prosperity depends on achieving the joint goals of economic, environmental and social sustainability. This understanding has resulted in both firms and actors on the financial markets enhancing their focus on environmental, social and governance dimensions
Recently, research on the edge states of 2D lead halide perovskites (LHPs) has been attracting much attention. The lower-energy edge state (LES) is believed to provide an efficient pathway for the dissociation of photoexcited excitons. However, the mechanism of the LES formation remains controversial, and studies that establish precisely the local electronic properties are lacking. Herein, the fir
BackgroundResearch is limited about how the introduction of new ways of delivering and conducting occupational therapy, in accordance with expected changes in health care, is experienced by occupational therapists (OTs).AimTo explore how OTs experienced use of a new internet-based intervention, ‘Strategies for Empowering activities in Everyday life’ (SEE), focusing on supporting client resources t
Baserat på fullständiga sammanställningar av subskriptionerne på 2 Timoteusbrevet i 485 grekiska manuskript, presenterar denna studie texttraditionen och utvecklingen av dessa subskriptioner och förklarar deras förhållande till andra subskriptioner, paratexter, de interna material i 1–2 Timoteus, Apostlagärningarna och det bredare. kyrkohistoria. Studien spårar källan/källorna bakom traditionen atBased on full collations of the subscriptions to 2 Timothy in 485 Greek manuscripts, this study presents the textual tradition and development of these subscriptions and explains their relationship to other subscriptions, paratexts, the internal evidence in 1–2 Timothy, Acts, and the wider church history. The study tracks the source(s) behind the tradition that the letter was sent to Timothy, inst
Pandemin med Covid-19 har slagit hårt mot många branscher. För att mildra skadeverkningarna infördes stödåtgärder i flera länder och så även i Sverige. I den här rapporten presenterar vi en genomgång av effekterna av pandemin för svensk fiskenäring. Vi undersöker också vilka stöd näringen har kunnat söka och i vilken mån stöden passar fiskenäringens struktur.Generellt sett hade svenskt yrkesfiske
Democratic theory and research have lately been criticized in several fields. A classic and contested question is the role of the working class in democracy and democratization. Yet, it has been overshadowed by elite strategies that have been at the core of the most influential analytical framework in regard to late twentieth-century transitions. This is where some of the criticism has been laid.
The quality inspection of wooden boards is experiencing a large change. By the use of camera and laser technology board characteristics and defects can be instantly identified and measured. This thesis investigates how the information from a quality inspection system can be used to classify boards into different quality classes, by the use of statistical classification models. Two types of classif
The national plebiscite in Colombia regarding the peace agreement between the government and FARC (Revolutionary Armed Forces of Colombia) was held on October 2nd 2016 and was suprisingly won by the No-side with a minimum of votes resulting in a rejection of the current peace deal. Yet, a majority of the Colombian people did not show up at the polls to vote. Less than 40% of the electorates actual
