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The Australian Bogong moth (Agrotis infusa) is a small noctuid moth that undertakes annual, nocturnal migrations of up to 1000 km to escape the summer heat of its breeding grounds. The moths travel to cool alpine caves, where they enter a dormant state (aestivation) before returning to reproduce and die. During migration, their brains integrate magnetic and visual cues to guide their flight direct
Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are associated with the formation of amyloid fibrils. The DNAJB6b (JB6) chaperone greatly inhibits the disease-related self-assembly of amyloid peptides in an ATP-independent manner. The molecular basis of this process is, however, not understood. Here, we studied the low complexity linker between the N- and C-terminal doma
Artificial intelligence (AI) methods are powerful tools for biological image analysis and processing. High-quality annotated images are key to training and developing new algorithms, but access to such data is often hindered by the lack of standards for sharing datasets. We discuss the barriers to sharing annotated image datasets and suggest specific guidelines to improve the reuse of bioimages an
Most scientific instruments currently discard rich streams of commands, data and metadata from which AI systems could learn to conduct experiments with expert-level decision-making and troubleshooting skills. Recording and using this data at scale requires rethinking what data to store, incentivizing large-scale cooperation, and determining how to quantify the reliability of such autonomous system
Packaging logistics is fundamental to the success of retail supply chains. Implementing systemwide change in this field is however complex. This paper introduces packaging logistics in retail supply chains and compares and contrasts the change processes in the introduction of plastic trays to retail food systems in the UK and Sweden.
Religious argumentation is sometimes supposed to be different from other kinds of argumentation. George Kennedy for example mentions a radical Christian rhetoric in which the message is proclaimed rather than argued, but in my study of Paul’s first letter to the Corinthians I have found deliberate argumentation. This argumentation can be analyzed with Toulmin’s model of argumentation. The warrants
Historical review of 100 years of relationship between Christians and Muslims in East Africa, with particular reference to challenges of the Christian theological education in relation to Islam.
Falsterbo Peninsula on the south coast of Sweden is low-lying and exposed to flooding. In 1872 the extreme storm surge Backafloden caused large devastation on the Swedish, Danish, and German coasts in the South Baltic Sea. For the Falsterbo Peninsula, the peak storm surge level is estimated to have been 240 cm above normal. If a similar event happened today, the consequences would be far worse, as
Nanowires (NWs) have unique electrical and optical properties of value for many applications including lighting, sensing, and energy harnessing. Consumer products containing NWs increase the risk of NWs being released in the environment, especially into aquatic ecosystems through sewage systems. Daphnia magna is a common, cosmopolitan freshwater organism sensitive to toxicity tests and represents
Background Abiraterone acetate (AA) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. To measure treatment response accurately in bone, quantitative methods are needed. The Bone Scan Index (BSI), a prognostic imaging biomarker, reflects the tumour burden in bone as a percentage of the total skeletal mass calculated from bone scintigraphy. Objective To evaluate
Healthcare inequality is ubiquitous globally, but the effects are most striking in low-resource settings. In these settings, current methods for the design of medical devices are failing to address specific needs. The associated publications rarely describe how the context was studied at the front-end of design. There is a latent need for a holistic contextual framework for guiding the design deci
The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observ
A high resolution TPC is the main option for a central tracking detector at the future International Linear Collider (ILC). It is planned that the MPGD (Micro Pattern Gas Detector) technology will be used for the readout. A Large Prototype TPC at DESY has been used to test the performance of MPGDs in an electron beam of energies up to 6 GeV. The first step in the technology development was to demo
