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Recent data shows that fibroblast growth factor 14 (FGF14) binds to and controls the function of the voltage-gated sodium (Nav) channel with phenotypic outcomes on neuronal excitability. Mutations in the FGF14 gene in humans have been associated with brain disorders that are partially recapitulated in Fgf14(-/-) mice. Thus, signaling pathways that modulate the FGF14:Nav channel interaction may be
Background: The objective of this study was to explore the prognostic value of the Bone Scan Index (BSI) obtained at the time of diagnosis in a group of high-risk prostate cancer patients receiving primary hormonal therapy. Methods: This was a retrospective study based on 130 consecutive prostate cancer patients at high risk, based on clinical stage (T2c/T3/T4), Gleason score (8 to 10) and prostat
Dolphin sonar has been extensively studied over several decades, and much of its basic characteristics are well known (Au 1993). However, most of these studies have been based on an experimental setup where the dolphin has been trained to be voluntarily fixed, so its directional sonar beam could be recorded with fixed hydrophones. Although this allows for very exact measurements, it most likely ha
A computerized paradigm was created to allow for testing in the laboratory whether increasing systematicity helps the recruiter make better selection decisions. Participants were introduced to the job and the applicants on the computer screen and asked to select who they thought should be considered for the job and who should not. Level of systematicity, i.e. the extent to which the recruitment is
Energy-intensive processing industries (EPIs) produce iron and steel, aluminum, chemicals, cement, glass, and paper and pulp and are responsible for a large share of global greenhouse gas emissions. To meet 2050 emission targets, an accelerated transition towards deep decarbonization is required in these industries. Insights from sociotechnical and innovation systems perspectives are needed to bet
Antigenic diversity in pathogenic microbes can be a result of at least three different processes: diversifying selection by acquired immunity, host–pathogen coevolution and/or host specialization. Here, we investigate whether host specialization drives diversity at ospC (which encodes an immunodominant surface protein) in the tick-transmitted bacterium Borrelia afzelii. We determined prevalence an
The capacity of communities to reduce negative impacts of climate change on their lives and livelihoods is a function of socio-economic conditions, infrastructure, government accountability and institutional responsiveness and not the least social capital. Africa’s most densely populated region, the Lake Victoria basin (LVB), home to over 30 million people, is one example of a likely future climat
The aim of the study was to explore what adolescents with congenital heart disease (CHD) view as important in the preparation for the transfer to adult care. We performed interviews in four focus groups with adolescents (14–18 years old) at four university hospitals in Sweden. Data was analysed using qualitative content analysis. The analysis revealed one main category; Becoming a manager of the c
Human Protein Reference Database (HPRD) is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease. Data pertaining to thousands of protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization were extracted from the literature
The ability to rapidly detect cell free circulating (cfc) DNA and other nanoparticulate disease biomarkers directly in blood is a major challenge for nanomedicine. We now show that AC Electrokinetic (ACE) microelectrode array devices can be used to rapidly isolate and detect cfc-DNA nanoparticulates directly from whole blood and other high conductance samples (plasma, serum etc.). The device shows
Scholarship on branding has made important contributions in terms of the value-creating function of branding. However, previous literature has overemphasized the creation of value for organizations at the expense of an understanding of the destructive side of branding for organizations and society. Drawing on the work of Boltanski and Thevénot, we theorize value as different in separate ‘worlds of
The method of angular- and wavelength-dispersive (e.g. two-dimensional) Rietveld refinement is a new and emerging tool for the analysis of neutron diffraction data measured at time-of-flight instruments with large area detectors. Following the approach for one-dimensional refinements (using either scattering angle or time of flight), the first step at each beam time cycle is the calibration of the
The result of a search for pair production of the supersymmetric partner of the Standard Model bottom quark (b~1) is reported. The search uses 3.2 fb- 1 of pp collisions at s=13 TeV collected by the ATLAS experiment at the Large Hadron Collider in 2015. Bottom squarks are searched for in events containing large missing transverse momentum and exactly two jets identified as originating from b-quark
Succinate:quinone reductases are membrane-bound enzymes that catalyze electron transfer from succinate to quinone. Some enzymes in vivo reduce ubiquinone (exergonic reaction) whereas others reduce menaquinone (endergonic reaction). The succinate:menaquinone reductases all contain two heme groups in the membrane anchor of the enzyme: a proximal heme (heme b(P)) located close to the negative side of
The aecA and aecB loci map at 250 and 290 degrees, respectively, on the Bacillus subtilis chromosomal genetic map. The aecB locus has been proposed as the structural gene for aspartokinase II. From DNA sequence analyses and comparisons to the sequence of the aspartokinase II gene, it can be concluded that the structural gene for aspartokinase II is located close to sdh at 250 degrees and cannot be
Due to water scarcity, there is great interest in reusing various nutrient-rich wastewaters. The aim of this article is consequently to evaluate if domestic wastewater treated by various wetland systems can be successfully recycled to irrigate generations of commercial crops such as Chilli (Capsicum annuum) grown in compost within a laboratory environment to obtain a cultivar adapted to domestic w
