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Dermatan sulfate is a highly sulfated polysaccharide and has a variety of biological functions in development and disease. Iduronic acid domains in dermatan sulfate, which are formed by the action of two DS-epimerases, have a key role in mediating these functions. We have identified the catalytic site and three putative catalytic residues in DS-epimerase 1, His205, Tyr261 and His450, by tertiary s
Intestinal-derived chemokines have a central role in orchestrating immune cell influx into the normal and inflamed intestine. Here, we identify the chemokine CCL6 as one of the most abundant chemokines constitutively expressed by both murine small intestinal and colonic epithelial cells. CCL6 protein localized to crypt epithelial cells, was detected in the gut lumen and reached high concentrations
BACKGROUND AND AIMS: More knowledge is needed about patterns of healthcare consumption at different times during old age, particularly with regard to the relationship between various agents in the healthcare and social services system. One aim was to investigate healthcare costs in the public medical healthcare system in men and women (65+) and, with regard to age, in the two years prior to the st
A newly developed aluminium-polymer-laminated steel reflector for use in solar concentrators was evaluated with respect to its optical properties, durability, and reflector performance in solar thermal and photovoltaic systems. The optical properties of the reflector material were investigated using spectrophotometer and scatterometry. The durability of the reflector was tested in a climatic test
The construction of an urea sensitive device based on a conducting polymer is described. The conducting polymer (polypyrrole) was exposed only to a gas-phase; this led to a significant improvement in its stability. A DC-resistometric measuring principle was used, which required only simple measuring equipment. The device responded rapidly to between 0 and 500 mM urea, with resistance changes of be
Background People applying for a housing adaptation (HA) grant are at great risk of participation restrictions due to declining capacity and environmental barriers. Aim To investigate the association of person-, environment-, and activity-related factors with participation frequency and satisfaction among people applying for a housing adaptation grant. Material and methods Baseline cross-sectional
The increase of obesity and type 2 diabetes on a global scale has increased the interest in how to counteract this epidemic. Improved lifestyle in general is a fundamental approach, but other remedies such as specific weight reduction or diabetes preventive drugs and surgery have also been tested. One problem to understand is what really happens after weight loss. Ongoing studies will try to addre
The main purpose of this study was to investigate whether the outcome obtained at the end of a work rehabilitation programme for people with various disabilities were stable in a one-year perspective. An additional aim was to explore which factors influenced the outcome upon completion of work rehabilitation and at the one-year follow-up. The study used information from a database and comprised 29
To accomplish timing recovery/synthesis in high-speed communication systems, a 24-b numerically controlled oscillator (NCO) IC using a circuit design technique called true single-phase clock (TSPC) pipelined CMOS has been fabricated in a standard 1.2-μm CMOS process. The device achieves a maximum tested input clock rate of 700 MHz, which results in an output frequency tuning range from DC up to 35
The aim of this study was to validate the Edholm scale (Edholm, 1966) and the ISO 8996 standard (International Organization for Standardization [ISO], 1990) by comparing the metabolic rates estimated for both methods with the actual measured metabolic rate (MMeas) in 6 manual material handling tasks simulated under laboratory conditions. The metabolic rate was calculated from oxygen consumption VO
Objective – The role of the academic librarian has become increasingly educative in nature. In this study, the critical friend method was introduced among teaching librarians in an academic setting of medicine and health sciences to ascertain whether this approach could be implemented for feedback on teaching of these librarians as part of their professional development. Methods – We used a singl
The optical spectra of a quantum cascade laser structure under nonequilibrium conditions is studied using the technique of nonequilibrium Green functions. We focus on the impact of Coulomb corrections and their dependence on the operating conditions. The role of the static mean field due to the charge distribution by electrons and ioninzed donors is investigated.
Objective: Compare perioperative course and long-term mortality after liver resection for colorectal cancer (CRC) metastases between patients who had preoperative treatment with portal vein embolization (PVE) and chemotherapy or chemotherapy alone. Methods: Among patients undergoing liver resection for CRC metastases following preoperative chemotherapy treatment, 17 patients who had received pre
Controlled resistive loads can contribute to damping of electro-mechanical oscillations. This paper presents an on-off damping controller for a single machine system. It was used at a field test in Southern Sweden to damp oscillations of a 0.9 MW hydro power generator. The controller used estimated machine frequency as input and controlled a 20 kW resistive load via thyristor switches. The field m
INTRODUCTION: As more patients survive coronary events, the prevalence of patients with refractory angina pectoris is increasing. The aim was to evaluate the effects of enhanced external counterpulsation (EECP) and spinal cord stimulation (SCS) and compare with optimal medically treated patients with refractory angina. METHODS: 153 patients with refractory angina were treated with either EECP, SCS
